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All Key Events

Showing 1226 to 1250 of 1907 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1690	Decrease, circulating testosterone levels Short Name	2	Tissue	Aug 30, 2019	Jan 27, 2025	12 AOPs 307: Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring 526: Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Impaired, Spermatogenesis 124: HMG-CoA reductase inhibition leading to decreased fertility 18: PPARα activation in utero leading to impaired fertility in males 51: PPARα activation leading to impaired fertility in adult male rodents 496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish） 64: Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility 120: Inhibition of 5α-reductase leading to Leydig cell tumors (in rat) 288: Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals) 570: Decreased testosterone synthesis leading to hypospadias in male (mammalian) offspring 575: Decreased testosterone synthesis leading to increased nipple retention (NR) in male (rodent) offspring 595: Emerging OPFRS reproductive outcome pathway
1691	Antagonism,LH receptor Short Name Antagonism,LH receptor	0	Molecular	Oct 3, 2019	Oct 3, 2019	309: Luteinizing hormone receptor antagonism leading to reproductive dysfunction
1692	Reduction, Progesterone synthesis Short Name Reduction, Progesterone synthesis	0	Cellular	Oct 3, 2019	Oct 3, 2019	309: Luteinizing hormone receptor antagonism leading to reproductive dysfunction
1693	Decreased, Progesterone levels Short Name Decreased, Progesterone levels	0	Tissue	Oct 3, 2019	Apr 8, 2025	309: Luteinizing hormone receptor antagonism leading to reproductive dysfunction
1694	Reduction, progesterone uptake, decresed maturation Short Name	0	Cellular	Oct 3, 2019	Oct 3, 2019	309: Luteinizing hormone receptor antagonism leading to reproductive dysfunction
1695	Impaired ovulation Short Name Impaired ovulation	1	Organ	Oct 3, 2019	Jan 3, 2025	2 AOPs 309: Luteinizing hormone receptor antagonism leading to reproductive dysfunction 566: Decreased, GnRH pulsatility/release leading to estradiol availability, increased via impaired ovulation
1696	Decrease of egg production and cummulative fecundity Short Name	0	Individual	Oct 3, 2019	Oct 3, 2019	3 AOPs 309: Luteinizing hormone receptor antagonism leading to reproductive dysfunction 396: Deposition of ionizing energy leads to population decline via impaired meiosis 595: Emerging OPFRS reproductive outcome pathway
1697	Increase, DNA methyltransferase expression Short Name Increase, DNMT expression	0	Molecular	Oct 30, 2019	Oct 30, 2019	310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR
1698	Increase, hypermethylation of the promotor region of gonadotropin releasing hormone receptor Short Name	0	Molecular	Oct 30, 2019	Oct 30, 2019	310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR
1699	Decrease, expression of gonadotropin releasing hormone receptor Short Name Decease, expression of GnRHR	0	Molecular	Oct 30, 2019	Oct 30, 2019	310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR
1700	Impaired IL-1R1 signaling in T cell Short Name Impaired IL-1R1 signaling	1	Molecular	Nov 17, 2019	Mar 2, 2023	277: Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response
1701	Suppression of NF-kB Short Name Suppression of NF-kB	0	Molecular	Nov 17, 2019	Nov 17, 2019	None
1702	Suppression of T cell activation Short Name Suppression of T cell activation	1	Cellular	Nov 17, 2019	Mar 6, 2023	277: Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response
1703	Dysregulation of heart rate and vascular tone Short Name Cardiovascular dysregulation	0	Organ	Nov 25, 2019	Dec 20, 2019	16: Acetylcholinesterase inhibition leading to acute mortality
1704	testJF Short Name test	0	Molecular	Dec 5, 2019	Dec 5, 2019	None
1705	Impaired coordination and movement Short Name Impaired coordination and movement	0	Individual	Dec 20, 2019	Dec 20, 2019	312: Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement
1706	Stimulation, TLR7/8 Short Name Stimulation of TLR7/8	0	Molecular	Dec 27, 2019	Nov 21, 2020	313: Stimulation of TLR7/8 in dendric cells leading to Psoriatic skin disease
1707	Increase, IL-23 from matured dendritic cells Short Name Increase of IL-23	0	Cellular	Dec 27, 2019	Nov 23, 2020	313: Stimulation of TLR7/8 in dendric cells leading to Psoriatic skin disease
1708	Th17 cell migration and inflammation induction Short Name	0	Cellular	Dec 27, 2019	Nov 23, 2020	2 AOPs 313: Stimulation of TLR7/8 in dendric cells leading to Psoriatic skin disease 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
1709	Psoriatic skin disease Short Name Skin disease	0	Individual	Dec 27, 2019	Nov 23, 2020	313: Stimulation of TLR7/8 in dendric cells leading to Psoriatic skin disease
1710	Binding to estrogen receptor (ER)-α in immune cells Short Name Binding to estrogen receptor (ER)-α	0	Molecular	Dec 29, 2019	Aug 14, 2020	314: Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE)
1711	Induction of GATA3 expression Short Name Induction of GATA3 expression	0	Cellular	Dec 29, 2019	Aug 14, 2020	314: Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE)
1712	Increase of Th2 cells producing IL-4 Short Name Increase of Th2 cells producing IL-4	0	Cellular	Dec 29, 2019	Aug 14, 2020	314: Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE)
1713	Increase of anti-DNA antibody from autoreactive B cell Short Name Increase of autoantibody production	0	Cellular	Dec 29, 2019	Aug 14, 2020	314: Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE)
1714	Exacerbation of systemic lupus erythematosus (SLE) Short Name Exacerbation of SLE	0	Individual	Dec 29, 2019	Aug 14, 2020	314: Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE)