AOP-Wiki

API

All Key Events

Showing 1501 to 1525 of 1907 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1998	Activation, Microglia Short Name Microglia activation	0	Cellular	Apr 7, 2022	Apr 7, 2022	490: Co-activation of IP3R and RyR leads to reduced IQ and increased socio-economic burden through non-cholinergic mechanisms
1999	Increased mortality of neurodegenerative diseases Short Name	0	Population	Apr 7, 2022	Apr 7, 2022	None
2000	Vascular calcification Short Name Vascular calcification	0	Organ	Apr 21, 2022	Apr 21, 2022	None
2001	Cardiac hypertrophy Short Name Cardiac hypertrophy	0	Organ	Apr 22, 2022	Apr 22, 2022	None
2002	Ventricular remodeling Short Name Ventricular remodeling	0	Organ	Apr 22, 2022	Apr 22, 2022	None
2003	Vascular remodeling Short Name Vascular remodeling	0	Organ	Apr 22, 2022	Apr 22, 2022	None
2004	Increased, secretion of catecholamine Short Name Increased, secretion of catecholamine	0	Cellular	Apr 22, 2022	Apr 22, 2022	None
2005	Altered neurotransmission in development Short Name neurotrasmission in development	1	Cellular	May 16, 2022	Jul 24, 2024	442: Binding to voltage gate sodium channels during development leads to cognitive impairment
2006	Secondary genotoxicity Short Name Secondary genotoxicity	1	Cellular	May 25, 2022	May 25, 2022	451: Interaction with lung resident cell membrane components leads to lung cancer
2007	Non-coding RNA expression profile alteration Short Name Non-coding RNA expression，alteration	0	Molecular	May 31, 2022	May 31, 2022	452: Adverse outcome pathway of PM-induced respiratory toxicity
2008	Chronic obstructive pulmonary disease Short Name Chronic obstructive pulmonary disease	0	Individual	May 31, 2022	May 31, 2022	452: Adverse outcome pathway of PM-induced respiratory toxicity
2009	Activation of inflammation pathway Short Name Activation, inflammation pathway	0	Cellular	May 31, 2022	May 31, 2022	3 AOPs 452: Adverse outcome pathway of PM-induced respiratory toxicity 507: Nrf2 inhibition leading to vascular disrupting effects via inflammation pathway 511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
2010	Pulmonary inflammation Short Name Pulmonary inflammation	0	Organ	May 31, 2022	May 31, 2022	2 AOPs 452: Adverse outcome pathway of PM-induced respiratory toxicity 481: AOPs of amorphous silica nanoparticles: ROS-mediated oxidative stress increased respiratory dysfunction and diseases.
2011	Emphysema Short Name Emphysema	0	Organ	May 31, 2022	May 31, 2022	452: Adverse outcome pathway of PM-induced respiratory toxicity
2012	Fibroblast proliferation and differentiation Short Name	0	Cellular	May 31, 2022	May 31, 2022	452: Adverse outcome pathway of PM-induced respiratory toxicity
2013	Airway remodeling Short Name Airway remodeling	0	Organ	May 31, 2022	May 31, 2022	452: Adverse outcome pathway of PM-induced respiratory toxicity
2014	Intestinal epithelial cell apoptosis Short Name Intestinal epithelial cell apoptosis	0	Cellular	Jun 6, 2022	Jun 7, 2022	None
2015	Intestinal inflammation Short Name Intestinal inflammation	0	Organ	Jun 6, 2022	Jun 6, 2022	None
2016	Hepatocyte cell apoptosis Short Name Hepatocyte cell apoptosis	0	Cellular	Jun 7, 2022	Jun 7, 2022	None
2017	Endoplasmic reticulum stress Short Name Endoplasmic reticulum stress	0	Cellular	Jun 27, 2022	Jun 27, 2022	2 AOPs 454: PM2.5-related AOP frameworks on liver diseases 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
2019	Non-alcoholic fatty liver disease Short Name Non-alcoholic fatty liver disease	0	Individual	Jun 27, 2022	Jun 27, 2022	2 AOPs 454: PM2.5-related AOP frameworks on liver diseases 591: DBDPE-induced DNA damage increase in liver leading to Non-alcoholic fatty liver disease via liver steatosis and inhibition of regeneration
2020	Decrease, sox9 expression Short Name Decrease, sox9 expression	1	Molecular	Jun 28, 2022	Sep 25, 2024	2 AOPs 455: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development 456: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity
2021	Increase, slincR expression Short Name Increase, slincR expression	1	Molecular	Jun 29, 2022	Aug 1, 2022	2 AOPs 455: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development 456: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity
2022	Altered function of the brain Short Name brain function	0	Organ	Jul 6, 2022	Jul 6, 2022	None
2023	Inhibition of Ceramide Synthase Short Name Inhibition CerS	0	Molecular	Jul 14, 2022	Jul 19, 2022	449: Ceramide synthase inhibition leading to neural tube defects