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All Key Events

Showing 1651 to 1675 of 1907 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

2151	Disruption, neurotransmitter release Short Name Disruption, neurotransmitter release	1	Molecular	Jun 27, 2023	Jul 21, 2023	4 AOPs 499: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via disrupted neurotransmitter release 471: Neuron defect induced early behavioral change 535: Binding and activation of GPER leading to learning and memory impairments 564: DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity.
2152	Epigenetic modification process Short Name Epigenetic modification process	0	Cellular	Jul 27, 2023	Apr 28, 2025	503: Activation of uterine estrogen receptor-alfa leading to endometrial adenocarcinoma, via epigenetic modulation
2153	Expression of factors ruling proliferation, modified Short Name	0	Cellular	Jul 27, 2023	Apr 28, 2025	503: Activation of uterine estrogen receptor-alfa leading to endometrial adenocarcinoma, via epigenetic modulation
2154	Uterine adenocarcinoma (endometrioid adenocarcinoma Type I) Short Name endometrioid adenocarcinoma Type I	0	Organ	Jul 27, 2023	Mar 6, 2025	503: Activation of uterine estrogen receptor-alfa leading to endometrial adenocarcinoma, via epigenetic modulation
2155	Inhibition of Sulfotransferase E1 (SULT1E1) Short Name SULT1E1 inhibition	1	Molecular	Jul 28, 2023	Feb 21, 2025	504: SULT1E1 inhibition leading to uterine adenocarcinoma via increased estrogen availability at target organ level
2156	Increased morbidity of congenital heart defect Short Name	0	Population	Jul 31, 2023	Jul 31, 2023	None
2157	Abnormal Cardiac Structure and Function Short Name	0	Organ	Jul 31, 2023	Jul 31, 2023	557: β2-Receptor agonist leading to Cardiomyopathy
2158	Influenza A Virus (IAV) binds sialic acid glycan receptor Short Name IAV binds receptor	1	Molecular	Jul 31, 2023	Aug 2, 2023	506: Binding of Influenza A Virus (IAV) to Sialic Acid Glycan Receptor leads to viral infection proliferation
2159	Influenza A virus (IAV) cell entry Short Name IAV cell entry	3	Cellular	Aug 11, 2023	Oct 3, 2023	506: Binding of Influenza A Virus (IAV) to Sialic Acid Glycan Receptor leads to viral infection proliferation
2160	Angiogenesis disfunction Short Name Angiogenesis disfunction	0	Organ	Aug 19, 2023	Aug 19, 2023	None
2161	Increase, Vascular disrupting effects Short Name Increase, Vascular disrupting effects	0	Individual	Aug 19, 2023	Aug 19, 2023	6 AOPs 507: Nrf2 inhibition leading to vascular disrupting effects via inflammation pathway 508: Nrf2 inhibition leading to vascular disrupting effects through activating HIF1α, Semaphorin 6A, and Dll4-Notch pathway 509: Nrf2 inhibition leading to vascular disrupting effects through activating apoptosis signal pathway and mitochondrial dysfunction 510: Demethylation of PPAR promotor leading to vascular disrupting effects 511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects 538: Adverse outcome pathway of PFAS-induced vascular disrupting effects via activating oxidative stress related pathways
2162	Activation, HIF1α Short Name Activation, HIF1α	0	Cellular	Aug 20, 2023	Aug 20, 2023	508: Nrf2 inhibition leading to vascular disrupting effects through activating HIF1α, Semaphorin 6A, and Dll4-Notch pathway
2163	Activation Sema6A Short Name Activation Sema6A	0	Cellular	Aug 20, 2023	Aug 20, 2023	508: Nrf2 inhibition leading to vascular disrupting effects through activating HIF1α, Semaphorin 6A, and Dll4-Notch pathway
2164	Activation, Dll4-Notch pathway Short Name Activation, Dll4-Notch pathway	0	Cellular	Aug 20, 2023	Aug 20, 2023	2 AOPs 508: Nrf2 inhibition leading to vascular disrupting effects through activating HIF1α, Semaphorin 6A, and Dll4-Notch pathway 511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
2165	Activation of PPAR Short Name Activation of PPAR	0	Cellular	Aug 20, 2023	Aug 20, 2023	510: Demethylation of PPAR promotor leading to vascular disrupting effects
2166	Abnormal expression of NO Short Name Abnormal expression of NO	0	Cellular	Aug 20, 2023	Aug 20, 2023	510: Demethylation of PPAR promotor leading to vascular disrupting effects
2167	Activation of MMP-2 MMP-9 Short Name Activation of MMP-2 MMP-9	0	Cellular	Aug 20, 2023	Aug 20, 2023	510: Demethylation of PPAR promotor leading to vascular disrupting effects
2168	Activation of angiopoietin like protein 4 Short Name	0	Cellular	Aug 20, 2023	Aug 20, 2023	510: Demethylation of PPAR promotor leading to vascular disrupting effects
2169	Activation of Angiogenic cytokines Short Name Activation of Angiogenic cytokines	0	Cellular	Aug 20, 2023	Aug 20, 2023	510: Demethylation of PPAR promotor leading to vascular disrupting effects
2170	Activated ANG/Tie2 pathway Short Name Activated ANG/Tie2 pathway	0	Molecular	Aug 21, 2023	Aug 21, 2023	511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
2171	Activated BMP/TGF-beta pathway Short Name Activated BMP/TGF-beta pathway	0	Cellular	Aug 21, 2023	Aug 21, 2023	511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
2172	Activated Wnt/Frizzled pathway Short Name Activated Wnt/Frizzled pathway	0	Cellular	Aug 21, 2023	Aug 21, 2023	511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
2173	Activated AKT/ERK/PI3K pathway Short Name Activated AKT/ERK/PI3K pathway	0	Cellular	Aug 21, 2023	Aug 21, 2023	511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
2174	Inhibition VEGF/VEGFR pathway Short Name Inhibition VEGF/VEGFR pathway	0	Cellular	Aug 21, 2023	Aug 21, 2023	511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
2175	Endothelial cell death Short Name Endothelial cell death	0	Cellular	Aug 21, 2023	Aug 21, 2023	None