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Showing 2851 to 2875 of 3081 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

1893	1629: Reduction in melanin level	1630: Reduction of melanosome level	May 3, 2019	May 3, 2019	1 AOP 292: Inhibition of tyrosinase leads to decreased population in fish
396	408: reduction in ovarian granulosa cells, Aromatase (Cyp19a1)	3: Reduction, 17beta-estradiol synthesis by ovarian granulosa cells	Nov 29, 2016	Nov 29, 2016	1 AOP 7: Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female
1638	1464: Reduction of collagen crosslinking	1465: Weak collagen matrix	Aug 3, 2017	Aug 3, 2017	1 AOP 242: Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
1892	1628: Reduction of L-Dopaquinone	1629: Reduction in melanin level	May 3, 2019	May 3, 2019	1 AOP 292: Inhibition of tyrosinase leads to decreased population in fish
1894	1630: Reduction of melanosome level	1631: Reduction fo Pigmentation pattern	May 3, 2019	May 3, 2019	1 AOP 292: Inhibition of tyrosinase leads to decreased population in fish
5	3: Reduction, 17beta-estradiol synthesis by ovarian granulosa cells	219: Reduction, Plasma 17beta-estradiol concentrations	Nov 29, 2016	Mar 20, 2017	6 AOPs 7: Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female 25: Aromatase inhibition leading to reproductive dysfunction 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) 122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation 123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR
3326	3: Reduction, 17beta-estradiol synthesis by ovarian granulosa cells	285: Reduction, Vitellogenin synthesis in liver	Jul 26, 2024	Jul 26, 2024	1 AOP 540: Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production
3624	3: Reduction, 17beta-estradiol synthesis by ovarian granulosa cells	1696: Decrease of egg production and cummulative fecundity	Sep 3, 2025	Sep 3, 2025	1 AOP 595: Emerging OPFRS reproductive outcome pathway
2145	1789: Reduction, E2 Synthesis by the undifferentiated gonad	1790: Increased, Differentiation to Testis	Jun 15, 2020	Jul 11, 2022	1 AOP 346: Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation
3229	1611: Reduction, androstenedione	1690: Decrease, circulating testosterone levels	May 24, 2024	Apr 8, 2025	1 AOP 288: Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals)
36	28: Reduction, Angiogenesis	110: Impairment, Endothelial network	Nov 29, 2016	Jan 18, 2022	1 AOP 43: Disruption of VEGFR Signaling Leading to Developmental Defects
3683	28: Reduction, Angiogenesis	2383: Increase, Hemopericardium	Oct 30, 2025	Oct 30, 2025	1 AOP 614: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via reduced vascular endothelial growth factor
59	49: Reduction, Ca and HCO3 transport to shell gland	106: Reduction, Eggshell thickness	Nov 29, 2016	Dec 3, 2016	1 AOP 28: Cyclooxygenase inhibition leading reproductive failure
438	447: Reduction, Cholesterol transport in mitochondria	413: Reduction, Testosterone synthesis in Leydig cells	Nov 29, 2016	Dec 2, 2016	2 AOPs 18: PPARα activation in utero leading to impaired fertility in males 51: PPARα activation leading to impaired fertility in adult male rodents
3517	447: Reduction, Cholesterol transport in mitochondria	2319: Decreased, Pregnenolone levels	Apr 8, 2025	Apr 8, 2025	None
94	78: Reduction, Cumulative fecundity and spawning	360: Decrease, Population growth rate	Nov 29, 2016	Mar 20, 2017	12 AOPs 25: Aromatase inhibition leading to reproductive dysfunction 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) 30: Estrogen receptor antagonism leading to reproductive dysfunction 122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation 123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR 289: Inhibition of 5α-reductase leading to impaired fecundity in female fish 216: Deposition of energy leading to population decline via DNA strand breaks and follicular atresia 238: Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis 540: Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production 299: Deposition of energy leading to population decline via DNA oxidation and follicular atresia 311: Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis
2142	78: Reduction, Cumulative fecundity and spawning	361: Decline, Population	May 25, 2020	May 25, 2020	None
2924	78: Reduction, Cumulative fecundity and spawning	442: Decreased, Population trajectory	May 22, 2023	May 22, 2023	2 AOPs 496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish） 549: Aromatase inhibition leads to reproductive toxicity (including growth and developmental toxicity) in adult female zebrafish
3228	1610: Reduction, DHEA	1690: Decrease, circulating testosterone levels	May 24, 2024	Apr 8, 2025	1 AOP 288: Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals)
123	106: Reduction, Eggshell thickness	253: N/A, Reproductive failure	Nov 29, 2016	Dec 3, 2016	1 AOP 28: Cyclooxygenase inhibition leading reproductive failure
460	446: Reduction of testosterone	414: Increase, Luteinizing hormone (LH)	Nov 29, 2016	Dec 3, 2016	None
608	446: Reduction of testosterone	348: Malformation, Male reproductive tract	Nov 29, 2016	Dec 2, 2016	None
1649	446: Reduction of testosterone	520: Decreased sperm quantity or quality in the adult, Decreased fertility	Aug 11, 2017	Aug 11, 2017	None
143	129: Reduction, Gonadotropins, circulating concentrations	274: Reduction, Testosterone synthesis by ovarian theca cells	Nov 29, 2016	Mar 20, 2017	1 AOP 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish)
667	64: Reduction, Ionotropic GABA receptor chloride channel conductance	669: Reduction, Neuronal synaptic inhibition	Nov 29, 2016	Apr 29, 2019	1 AOP 10: Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain

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