AOP-Wiki

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All KERs

Showing 2851 to 2875 of 3119 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

698	692: Reduced, Maturation inducing steroid receptor signalling, oocyte	695: Upregulated, Spindle assembly checkpoint protein Mad2-oocyte	Nov 29, 2016	Dec 3, 2016	1 AOP 103: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
693	691: Reduced, Maturation inducing steroid, plasma	692: Reduced, Maturation inducing steroid receptor signalling, oocyte	Nov 29, 2016	Dec 3, 2016	2 AOPs 102: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition 103: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
697	694: Reduced, Meiotic prophase I/metaphase I transition, oocyte	675: Reduced, Reproductive Success	Nov 29, 2016	Dec 3, 2016	1 AOP 102: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition
1536	1405: Reduced, mucosal defense	1385: Activated, gastric ulcer formation	Jun 2, 2017	Jun 2, 2017	2 AOPs 227: NSAID induced PTGS1 inactivation to gastric ulcer 229: Helicobacter pylori to gastric ulcer
1548	1405: Reduced, mucosal defense	1412: Helicobacter pylori infection	Jun 2, 2017	Jun 2, 2017	None
679	678: Reduced, Pheromone release	674: Reduced, Ability to attract spawning mates	Nov 29, 2016	Dec 3, 2016	1 AOP 101: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release
1533	1403: Reduced, platelet aggregation	1385: Activated, gastric ulcer formation	Jun 2, 2017	Jun 2, 2017	1 AOP 227: NSAID induced PTGS1 inactivation to gastric ulcer
1028	1004: Reduced, Posterior swim bladder inflation	1005: Reduced, Swimming performance	Nov 29, 2016	Sep 3, 2021	2 AOPs 155: Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation 157: Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation
1031	1004: Reduced, Posterior swim bladder inflation	1007: Reduced, Anterior swim bladder inflation	Nov 29, 2016	Nov 20, 2020	None
2213	1004: Reduced, Posterior swim bladder inflation	351: Increased Mortality	Nov 30, 2020	Sep 8, 2021	2 AOPs 155: Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation 157: Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation
1560	1422: Reduced, PPARalpha	1423: Reduced, HSD17B4 activity	Jun 2, 2017	Jun 2, 2017	1 AOP 232: NFE2/Nrf2 repression to steatosis
1551	1413: Reduced, presynaptic neuron 2 activity	1414: Decreased, GABA	Jun 2, 2017	Jun 2, 2017	1 AOP 231: presynaptic neuron 2 repression to epilepsy
357	383: Reduced, Presynaptic release of glutamate	385: Synaptogenesis, Decreased	Nov 29, 2016	Nov 29, 2016	1 AOP 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
690	687: Reduced, Prostaglandin E2 concentration, hypothalamus	689: Reduced, Gonadotropin releasing hormone, hypothalamus	Nov 29, 2016	Dec 3, 2016	2 AOPs 102: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition 103: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
672	671: Reduced, Prostaglandin F2alpha concentration, plasma	673: Reduced, Spawning behavior	Nov 29, 2016	Dec 3, 2016	1 AOP 100: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior
678	671: Reduced, Prostaglandin F2alpha concentration, plasma	678: Reduced, Pheromone release	Nov 29, 2016	Dec 3, 2016	1 AOP 101: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release
671	672: Reduced, Prostaglandin F2alpha synthesis, ovary	671: Reduced, Prostaglandin F2alpha concentration, plasma	Nov 29, 2016	Dec 3, 2016	1 AOP 100: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior
685	685: Reduced, Prostaglandins, ovary	488: Decrease, Ovulation	Nov 29, 2016	Dec 3, 2016	1 AOP 63: Cyclooxygenase inhibition leading to reproductive dysfunction
1532	1402: Reduced, PTGS1 function	1403: Reduced, platelet aggregation	Jun 2, 2017	Jun 2, 2017	1 AOP 227: NSAID induced PTGS1 inactivation to gastric ulcer
1534	1402: Reduced, PTGS1 function	1404: Decreased, mucosal blood flow	Jun 2, 2017	Jun 2, 2017	1 AOP 227: NSAID induced PTGS1 inactivation to gastric ulcer
1537	1402: Reduced, PTGS1 function	1406: Decreased, mucous	Jun 2, 2017	Jun 2, 2017	1 AOP 227: NSAID induced PTGS1 inactivation to gastric ulcer
1539	1402: Reduced, PTGS1 function	1407: Decreased, bicarbonate	Jun 2, 2017	Jun 2, 2017	1 AOP 227: NSAID induced PTGS1 inactivation to gastric ulcer
1541	1408: Reduced, PTGS2 function	1409: Decreased, angiogenesis	Jun 2, 2017	Jun 2, 2017	1 AOP 228: NSAID induced PTGS2 inactivation to gastric ulcer
1543	1408: Reduced, PTGS2 function	1410: Increased, leukocyte adherence	Jun 2, 2017	Jun 2, 2017	1 AOP 228: NSAID induced PTGS2 inactivation to gastric ulcer
675	675: Reduced, Reproductive Success	360: Decrease, Population growth rate	Nov 29, 2016	Dec 3, 2016	5 AOPs 100: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior 101: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release 102: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition 63: Cyclooxygenase inhibition leading to reproductive dysfunction 103: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint

Key Event Relationships (KERs)

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