Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 451 to 475 of 1141 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
691 increased acute inflammatory response (GO:0002526) Cytokine (FMA:84050) None
690 increased epithelial cell proliferation (GO:0050673) kidney tubule cell (CL:1000507) 710: Increase, Regenerative cell proliferation (tubular epithelial cells)
689 increased neuropeptide hormone activity (GO:0005184) Neurokinin A (CHEBI:80311) 1435: Increased neurokinin A (NKA) by neuronal cells
688 increased neuropeptide hormone activity (GO:0005184) Calcitonin gene-related peptide 1 (CHEBI:80337) 1433: Increased CGRP, neuronal release of CGRP
687 decreased glutamate secretion (GO:0014047) glutamate(1-) (CHEBI:14321) 383: Reduced, Presynaptic release of glutamate
686 increased NMDA glutamate receptor activity (GO:0004972) NMDA selective glutamate receptor complex (GO:0017146) 388: Overactivation, NMDARs
685 decreased NMDA glutamate receptor activity (GO:0004972) NMDA selective glutamate receptor complex (GO:0017146) 195: Inhibition, NMDARs
684 abnormal embryo development (GO:0009790) 1295: Defect of Embryogenesis
683 abnormal signaling (GO:0023052) Wnt signalosome (GO:1990909) 1294: Inhibition, Wnt pathway
682 increased signaling (GO:0023052) forkhead box protein O (Caenorhabditis elegans) (PR:O16850) 1293: Activation, FOXO
681 increased signaling (GO:0023052) JNK Mitogen-Activated Protein Kinases (MESH:D048031) 1292: Activation, JNK
680 abnormal glutathione (CHEBI:16856) 1290: Glutathione homeostasis
679 abnormal cholesterol (CHEBI:16113) 1289: Perturbation of cholesterol
678 decreased glutathione biosynthetic process (GO:0006750) glutathione (CHEBI:16856) 1287: Glutathione synthesis
677 decreased glutathione transferase activity (GO:0004364) glutathione S-transferase (PR:000029945) 1286: Down Regulation, GSS and GSTs gene
676 decreased glutathione synthase activity (GO:0004363) glutathione synthetase (PR:000008293) 1286: Down Regulation, GSS and GSTs gene
675 increased unsaturated fatty acid biosynthetic process (GO:0006636) unsaturated fatty acid (CHEBI:27208) 1285: Up Regulation, Unsaturated fatty acid
674 increased gene expression (GO:0010467) sterol regulatory element-binding protein 2 proteolytic cleavage product (PR:000021564) 1284: Up Regulation, SREBF2
673 increased signaling (GO:0023052) TGF-beta (PR:000000046) 1283: Activation, TGF-beta pathway
672 increased signaling (GO:0023052) signal transducer and transcription activator STAT (PR:000001933) 1282: Activation, JAK/STAT pathway
671 increased signaling (GO:0023052) Janus kinase (PR:000025748) 1282: Activation, JAK/STAT pathway
670 increased DNA repair (GO:0006281) deoxyribonucleic acid (CHEBI:16991) 1281: Increased, DNA Damage-Repair
669 increased signaling (GO:0023052) hypoxia-inducible factor 1 (Caenorhabditis elegans) (PR:G5EGD2) 1280: Activation, HIF-1
668 increased signaling (GO:0023052) map kinase p38 (PR:000003106) 1279: Increase, Oxidative Stress / Activation, PMK-1 P38 MAPK
667 increased biosynthetic process (GO:0009058) reactive oxygen species (CHEBI:26523) None