Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 926 to 950 of 1141 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
216 decreased cognition (GO:0050890) 402: Cognitive function, decreased
215 decreased learning or memory (GO:0007611) 402: Cognitive function, decreased
214 decreased thyroid hormone generation (GO:0006590) thyroid hormone (CHEBI:60311) 277: Thyroid hormone synthesis, Decreased
213 decreased iodide peroxidase activity (GO:0004447) thyroid peroxidase (PR:000016584) 279: Thyroperoxidase, Inhibition
212 increased Bile Duct Neoplasms (MESH:D001650) 856: Formation, Hepatocellular and Bile duct tumors
211 increased hyperplasia (MESH:D006965) intrahepatic bile duct epithelial cell (CL:0002538) 854: Alterations, Cellular proliferation / hyperplasia
210 increased hyperplasia (MESH:D006965) hepatic oval stem cell (CL:0002196) 854: Alterations, Cellular proliferation / hyperplasia
209 abnormal cell proliferation (GO:0008283) Liver cell (FMA:63179) 854: Alterations, Cellular proliferation / hyperplasia
208 occurrence Liver Diseases (MESH:D008107) 139: N/A, Hepatotoxicity, Hepatopathy, including a constellation of observable effects
207 decreased apoptotic process (GO:0006915)
206 abnormal cellular homeostasis (GO:0019725) 853: Changes/Inhibition, Cellular Homeostasis and Apoptosis
205 increased signaling (GO:0023052) aryl hydrocarbon receptor (PR:000003858) 165: Activation, Long term AHR receptor driven direct and indirect gene expression changes
204 increased cell proliferation (GO:0008283) memory T cell (CL:0000813) 272: Activation/Proliferation, T-cells
203 increased T cell activation (GO:0042110) T cell (CL:0000084) 272: Activation/Proliferation, T-cells
202 increased MHC protein complex assembly (GO:0002396) 398: Activation, Dendritic Cells
201 increased cell activation (GO:0001775)
200 increased cytokine production involved in inflammatory response (GO:0002534) 826: Activation, Keratinocytes
199 increased keratinocyte activation (GO:0032980) 826: Activation, Keratinocytes
198 increased protein binding (GO:0005515) electrophilic reagant (CHEBI:59739) 396: Covalent Binding, Protein
197 increased Respiratory Hypersensitivity (MESH:D012130) 313: Increase, Allergic Respiratory Hypersensitivity Response
196 increased cytokine activity (GO:0005125) Cytokine (FMA:84050) 151: Activation, Inflammatory cytokines, chemokines, cytoprotective gene pathways
195 increased chemokine activity (GO:0008009) Chemokine (FMA:241981) 151: Activation, Inflammatory cytokines, chemokines, cytoprotective gene pathways
194 increased covalent binding (MI:0195) xenobiotic (CHEBI:35703) 75: N/A, Covalent binding to protein, possibly lysine residue
193 increased transforming growth factor beta1 production (GO:0032905) TGF-beta 1 (PR:000000182) 276: Up Regulation, TGFbeta1 expression
192 occurrence liver fibrosis (MP:0003333) liver (UBERON:0002107)