Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 176 to 200 of 1141 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
966 abnormal animal organ formation (GO:0048645) epididymis (UBERON:0001301) 2212: Epididymal agenesis
965 decreased hormone biosynthetic process (GO:0042446) None
964 decreased viable offspring quantity (VT:1000181) 2147: Decreased, Viable Offspring
963 increased Abnormality of the testis (HP:0000035) Testis (FMA:7210) 2206: Increased, histomorphological alteration of testis
962 increased lipid oxidation (GO:0034440) polyunsaturated fatty acid (CHEBI:26208) 1445: Increase, Lipid peroxidation
961 increased hepatocyte (CL:0000182) None
960 increased Hepatic steatosis (HP:0001397) 459: Increase, Liver steatosis
959 increased Breast carcinoma (HP:0003002) BRCA1-A complex (GO:0070531) 1971: Increased, tumor growth
958 increased Breast carcinoma (HP:0003002) VEGF-A complex (GO:1990150) 1376: Increase, angiogenesis
957 occurrence transmission of virus (GO:0019089) 2194: Influenza A Virus (IAV) shedding and transmission
956 occurrence viral budding from plasma membrane (GO:0046761) 2193: Influenza A Virus (IAV) budding
955 occurrence modulation by virus of host immune response (GO:0075528) 2180: Immune mechanisms antagonized by viral proteins
954 occurrence virus induced gene silencing (GO:0009616) 2180: Immune mechanisms antagonized by viral proteins
953 occurrence suppression by virus of host cytokine production (GO:0046775) 2180: Immune mechanisms antagonized by viral proteins
952 occurrence virus maturation (GO:0019075) 2192: Influenza A Virus production increased
951 occurrence viral mRNA export from host cell nucleus (GO:0046784) 2192: Influenza A Virus production increased
950 occurrence nuclear export (GO:0051168) viral genome (GO:0019015) None
949 occurrence transcription, RNA-templated (GO:0001172) segmented viral genome (GO:0019017) 2192: Influenza A Virus production increased
948 occurrence protein import into nucleus (GO:0006606) viral RNA-directed RNA polymerase complex (GO:0031381) 2192: Influenza A Virus production increased
947 occurrence membrane fusion (GO:0061025) influenzavirus hemagglutinin (PR:000049750) None
946 occurrence pH reduction (GO:0045851) endosome (GO:0005768) None
945 occurrence vesicle targeting, plasma membrane to endosome (GO:0048201) None
944 occurrence clathrin-dependent endocytosis (GO:0072583) None
943 increased acute-phase response (GO:0006953) Acute phase proteins (N/A)
942 increased Atherosclerosis (HP:0002621) 1443: Atherosclerosis