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Showing 1 to 6 of 6 AOPs in Title Search Results

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ID	Title	Point of Contact	License	MIE	AO	OECD Status	OECD Project

199	ER mediated breast cancer AOP	Molly M Morgan	BY-SA	None	None
200	Estrogen receptor activation leading to breast cancer	Molly M Morgan	Open for adoption	111: Agonism, Estrogen receptor	1193: N/A, Breast Cancer
293	Increased DNA damage leading to increased risk of breast cancer	Jessica Helm	BY-SA	1194: Increase, DNA damage	3 AOs 185: Increase, Mutations 1192: Increased, Ductal Hyperplasia 1193: N/A, Breast Cancer	Under Development	1.80
294	Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer	Jessica Helm	BY-SA	1632: Increase in reactive oxygen and nitrogen species (RONS)	4 AOs 1194: Increase, DNA damage 185: Increase, Mutations 1192: Increased, Ductal Hyperplasia 1193: N/A, Breast Cancer	Under Development	1.80
439	Activation of the AhR leading to metastatic breast cancer	Louise Benoit	BY-SA	18: Activation, AhR	1982: metastatic breast cancer	Under Review	1.105
443	DNA damage and mutations leading to Metastatic Breast Cancer	Usha Adiga	BY-SA	1669: Increased, DNA damage and mutation	1982: metastatic breast cancer	Under Development	1.103

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ID	Title	Point of Contact	License	MIE	AO	OECD Status	OECD Project

505	Reactive Oxygen Species (ROS) formation leads to cancer via inflammation pathway	John Frisch	BY-SA	1115: Increase, Reactive oxygen species	885: Increase, Cancer
513	Reactive Oxygen (ROS) formation leads to cancer via Peroxisome proliferation-activated receptor (PPAR) pathway	John Frisch	BY-SA	1115: Increase, Reactive oxygen species	885: Increase, Cancer
534	Succinate dehydrogenase (SDH) inhibition leads to oxidative stress	Xavier COUMOUL	All rights reserved	2118: Succinate dehydrogenase, inhibited	1392: Increase, Oxidative Stress
546	Succinate dehydrogenase inactivation leads to cancer through hypoxic-like mechanisms	Sylvie Bortoli	All rights reserved	2118: Succinate dehydrogenase, inhibited	885: Increase, Cancer
638	Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis	Wei Mu	BY-SA	3 MIEs 2414: COL3A1 Signaling Pathway 87: Release, Cytokine 1115: Increase, Reactive oxygen species	2 AOs 344: Increase, Liver fibrosis 1395: Liver Cancer