AOP-Wiki

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All Key Events

Showing 576 to 600 of 1907 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1014	Induction, Somatic muscle paralysis Short Name Induction, Somatic muscle paralysis	1	Tissue	Nov 29, 2016	Sep 16, 2017	2 AOPs 160: Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality 471: Neuron defect induced early behavioral change
1015	Increased, Neuronal synaptic inhibition Short Name Increased, Neuronal synaptic inhibition	1	Cellular	Nov 29, 2016	Sep 16, 2017	3 AOPs 161: Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality 160: Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality 471: Neuron defect induced early behavioral change
1016	Inhibition, Feeding Short Name Inhibition, Feeding	1	Individual	Nov 29, 2016	Jan 14, 2025	4 AOPs 161: Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality 160: Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality 471: Neuron defect induced early behavioral change 568: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) leads to Inhibition, Feeding
1017	Reduced, Feeding 2 Short Name Reduced, Feeding 2	0		Nov 29, 2016	Nov 29, 2016	None
1018	Activation, Glutamate-gated chloride channels Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	2 AOPs 161: Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality 471: Neuron defect induced early behavioral change
1019	Induction, pharyngeal muscle paralysis Short Name Induction, pharyngeal muscle paralysis	1	Tissue	Nov 29, 2016	Sep 16, 2017	161: Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality
1020	Increased, induction of UDPGT's in liver Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	None
1021	Increased, T4/T3 catabolism Short Name Increased, T4/T3 catabolism	1	Cellular	Nov 29, 2016	Sep 16, 2017	None
1022	Decreased, serum T4/T3 Short Name Decreased, serum T4/T3	1	Tissue	Nov 29, 2016	Sep 16, 2017	None
1023	Increased, Thyroid-stimulating hormone (TSH) Short Name	1	Tissue	Nov 29, 2016	Sep 16, 2017	4 AOPs 162: Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse 190: Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis 110: Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse) 119: Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse)
1024	Increased, Hypertrophy and proliferation (follicular cell) Short Name	2	Cellular	Nov 29, 2016	Sep 16, 2017	None
1025	Increased, Hyperplasia (follicular cells) Short Name	1	Tissue	Nov 29, 2016	Sep 16, 2017	None
1026	Increased Apoptosis, Adenomas/carcinomas (follicular cell) Short Name	2	Tissue	Nov 29, 2016	Sep 16, 2017	None
1027	, Learning and memory, impairment Short Name , Learning and memory, impairment	0		Nov 29, 2016	Nov 29, 2016	None
1028	Activation of specific nuclear receptors, PPAR-gamma activation Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	3 AOPs 163: PPARgamma activation leading to sarcomas in rats, mice, and hamsters 72: Epigenetic modification of PPARG leading to adipogenesis 618: PPARgamma activation leads to a diminished vaccine response
1029	Increased, adipogenesis Short Name Increased, adipogenesis	1	Cellular	Nov 29, 2016	Sep 16, 2017	163: PPARgamma activation leading to sarcomas in rats, mice, and hamsters
1030	Increased, Short Name Increased,	0		Nov 29, 2016	Nov 29, 2016	None
1031	Increased, release of growth factors Short Name Increased, release of growth factors	0		Nov 29, 2016	Nov 29, 2016	None
1032	Increased, secretion of local growth factors Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 163: PPARgamma activation leading to sarcomas in rats, mice, and hamsters 171: Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat.
1033	Increased, proliferation of mesenchymal cells Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	163: PPARgamma activation leading to sarcomas in rats, mice, and hamsters
1034	Increased, IGF-1 (mouse) Short Name Increased, IGF-1 (mouse)	1	Cellular	Nov 29, 2016	Sep 16, 2017	163: PPARgamma activation leading to sarcomas in rats, mice, and hamsters
1035	Increased, Firbrosarcoma Short Name Increased, Firbrosarcoma	1	Tissue	Nov 29, 2016	Sep 16, 2017	163: PPARgamma activation leading to sarcomas in rats, mice, and hamsters
1036	Increased, liposarcoma Short Name Increased, liposarcoma	1	Tissue	Nov 29, 2016	Sep 16, 2017	163: PPARgamma activation leading to sarcomas in rats, mice, and hamsters
1037	Increased, hemagiosarcoma Short Name Increased, hemagiosarcoma	1	Tissue	Nov 29, 2016	Sep 16, 2017	163: PPARgamma activation leading to sarcomas in rats, mice, and hamsters
1038	Activation, beta-2 adrenergic receptor Short Name Activation, beta-2 adrenergic receptor	1	Molecular	Nov 29, 2016	Sep 16, 2017	2 AOPs 164: Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse 554: β-adrenergic receptor agonists leading to arrhythmias.