AOP-Wiki

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All Key Events

Showing 776 to 800 of 1907 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1222	SP (Substance P) release, Local increase of SP Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	196: Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation
1223	Trigeminal and/or vagal nerve excitation causes Airway Hyper-responsiveness,Cough, Dyspnea Short Name	4	Tissue	Nov 29, 2016	Sep 24, 2018	196: Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation
1224	Non-neuronal production of TNF, Epithelial irritation Short Name	2	Individual	Nov 29, 2016	Dec 3, 2016	None
1225	Immune system inflammation Short Name Leukocyte infiltration	2	Tissue	Nov 29, 2016	Sep 16, 2017	None
1226	Increased Respiratory irritability and Chronic Cough, Short Name Respiratory irritability	2	Organ	Nov 29, 2016	Sep 24, 2018	196: Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation
1227	TRPA1 activation, Chemical covalent binding to sulfhydyl group on TRPA1 receptor protein/NEK293 fibroblast cells Short Name	0		Nov 29, 2016	Nov 29, 2016	None
1228	TRPA1 activation, Classic receptor binding / HEK 293 cells (fibroclast), cho cells (ovary), noncovalently linkked) Short Name	0		Nov 29, 2016	Nov 29, 2016	None
1229	TRPA1 activation, Chemical covalent binding to sulfhydyl group on TRPA1 receptor protein/ HEK293 fibroblast cells Short Name	0		Nov 29, 2016	Nov 29, 2016	None
1230	TRPV1 activation, TRPV1 Short Name TRPV1 activation, TRPV1	1	Molecular	Nov 29, 2016	Dec 3, 2016	None
1231	Oxidization of biomolecules, Lipid bilayer and cellular proteins Short Name	0		Nov 29, 2016	Nov 29, 2016	None
1232	Production of nerve growth factor , Short Name Production of nerve growth factor ,	0		Nov 29, 2016	Nov 29, 2016	None
1233	Production, Nerve growth factor Short Name Production, Nerve growth factor	0		Nov 29, 2016	Nov 29, 2016	None
1234	Production of nerve growth factor , Epithelial irritation Short Name	2	Tissue	Nov 29, 2016	Dec 3, 2016	None
1235	Non-neuronal production of IL-8/CXCL1, Epithelial irritation Short Name	3	Tissue	Nov 29, 2016	Dec 3, 2016	None
1236	Generation of novel epitopes , Antigen presentation Short Name	1	Cellular	Nov 29, 2016	Dec 3, 2016	None
1237	Sensitization, Immune system Short Name Sensitization, Immune system	1	Individual	Nov 29, 2016	Dec 3, 2016	None
1238	Activation of oxidative stress pathway Short Name Oxidation	3	Molecular	Nov 29, 2016	Jun 19, 2017	594: Micro plastic effect on reproduction
1239	Altered, Gene Expression Short Name Altered, Gene Expression	1	Molecular	Nov 29, 2016	Mar 6, 2019	3 AOPs 200: Estrogen receptor activation leading to breast cancer 275: Histone deacetylase inhibition leads to neural tube defects 533: Retinoic acid receptor antagonism during neurodevelopment leading to impaired learning and memory
1240	Altered, Protein Production Short Name Altered, Protein Production	1	Cellular	Nov 29, 2016	Sep 16, 2017	200: Estrogen receptor activation leading to breast cancer
1241	Increased, Motility Short Name Increased, Motility	1	Cellular	Nov 29, 2016	Feb 28, 2024	2 AOPs 200: Estrogen receptor activation leading to breast cancer 439: Activation of the AhR leading to metastatic breast cancer
1242	Increased, Second Messenger Production Short Name Increased, Second Messenger Production	1	Cellular	Nov 29, 2016	Sep 16, 2017	200: Estrogen receptor activation leading to breast cancer
1243	Altered, Ca2+-calmodulin activated signal transduction Short Name	3	Cellular	Nov 29, 2016	Jun 7, 2018	4 AOPs 88: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste 89: Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure 77: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1 87: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure
1244	Mucus hypersecretion, Short Name Mucus hypersecretion,	0		Nov 29, 2016	Nov 29, 2016	None
1245	Mucus , Hypersecretion Short Name Mucus , Hypersecretion	0		Nov 29, 2016	Nov 29, 2016	None
1246	Lung function, Decrease Short Name Lung function, Decrease	0		Nov 29, 2016	Nov 29, 2016	None