AOP-Wiki

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All Key Events

Showing 1176 to 1200 of 1907 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1637	Retinaldehyde dehydrogenase inhibition Short Name Retinaldehyde dehydrogenase	0	Molecular	May 22, 2019	May 22, 2019	297: Inhibition of retinaldehyde dehydrogenase leads to population decline
1638	Retinoic acid (RA) synthesis decreased Short Name RA	0	Cellular	May 22, 2019	May 22, 2019	None
1639	Plasma RA level decreased Short Name Plasma RA	0	Tissue	May 22, 2019	May 22, 2019	None
1640	Altered, Photoreceptor patterning Short Name Altered, Photoreceptor patterning	0	Cellular	May 22, 2019	Jun 16, 2021	2 AOPs 297: Inhibition of retinaldehyde dehydrogenase leads to population decline 365: Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning
1641	Decreased retinoic acid (RA) synthesis Short Name retinoic acid	0	Cellular	May 22, 2019	May 22, 2019	297: Inhibition of retinaldehyde dehydrogenase leads to population decline
1642	Decreased plasma RA level Short Name plasma retinoic acid	0	Tissue	May 22, 2019	Nov 3, 2025	297: Inhibition of retinaldehyde dehydrogenase leads to population decline
1643	Altered, Visual function Short Name Altered, Visual function	1	Organ	May 22, 2019	Jul 8, 2022	5 AOPs 297: Inhibition of retinaldehyde dehydrogenase leads to population decline 399: Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos) 363: Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure 364: Thyroperoxidase inhibition leading to altered visual function via decreased eye size 365: Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning
1644	Impaired Ab production Short Name Impaired Ab production	0	Cellular	May 23, 2019	Jun 25, 2019	None
1645	Wnt ligand stimulation Short Name Wnt ligand stimulation	0	Molecular	May 28, 2019	May 29, 2019	None
1646	Frizzled activation Short Name Frizzled activation	0	Molecular	May 29, 2019	May 29, 2019	None
1647	GSK3beta inactivation Short Name GSK3beta inactivation	0	Molecular	May 29, 2019	Oct 5, 2021	410: GSK3beta inactivation leading to increased mortality via defects in developing inner ear
1648	β-catenin activation Short Name β-catenin activation	0	Molecular	May 29, 2019	May 29, 2019	None
1649	Snail, Zeb, Twist activation Short Name Snail, Zeb, Twist activation	0	Molecular	May 29, 2019	May 29, 2019	None
1651	Treatment-resistant gastric cancer Short Name Resistant gastric cancer	1	Tissue	May 29, 2019	Jun 12, 2025	298: Increase in reactive oxygen species (ROS) leading to human treatment-resistant gastric cancer
1652	Increase, S-adenosylmethionine depletion Short Name Increase, SAM depletion	0	Molecular	May 30, 2019	May 30, 2019	None
1653	Binding of inhibitor to mitochondrial complex III Short Name	0	Molecular	Jun 7, 2019	Jun 7, 2019	273: Mitochondrial complex inhibition leading to liver injury
1654	Binding of inhibitor to mitochondrial complex IV Short Name	0	Molecular	Jun 7, 2019	Jun 7, 2019	273: Mitochondrial complex inhibition leading to liver injury
1655	Binding of inhibitor to mitochondrial complex V Short Name	0	Molecular	Jun 7, 2019	Jun 7, 2019	273: Mitochondrial complex inhibition leading to liver injury
1656	Antagonism, Thyroid Receptor Short Name TR Antagnoism	0	Molecular	Jun 8, 2019	Jan 11, 2021	4 AOPs 300: Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 485: Thyroid hormone antagonism leading to impaired oligodendrocyte maturation during development and subsequent decreased cognition 525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
1657	Inhibition of cystathionine beta-synthase Short Name CBS inhibition	0	Molecular	Jun 14, 2019	Jun 14, 2019	301: Inhibition of Cystathionine Beta synthase leading to impaired the early development of anterior-posterior axis
1658	Inhibition of Methionine synthase Short Name Methionine synthase	0	Molecular	Jun 14, 2019	Jun 14, 2019	None
1659	Inhibition of Methylenetetrahydrofolate reductase Short Name MTHFR inhibition	0	Molecular	Jun 14, 2019	Jun 14, 2019	None
1660	Inhibition of betaine-homocysteine methyltransferase Short Name	0	Molecular	Jun 14, 2019	Jun 14, 2019	None
1661	Increased Homocysteine level Short Name Homocysteine increases	0	Cellular	Jun 14, 2019	Jun 14, 2019	301: Inhibition of Cystathionine Beta synthase leading to impaired the early development of anterior-posterior axis
1662	Increased plasma Homocysteine level Short Name plasma homocysteine increases	0	Tissue	Jun 14, 2019	Jun 14, 2019	None