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All Key Events

Showing 1776 to 1800 of 1907 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

2276	Increased, protein expression of proprotein convertase subtilisin/kexin type 9 (PCSK9) Short Name Increased, PCSK9 protein expression	1	Cellular	Nov 13, 2024	Feb 10, 2025	548: Activation, Pregnane-X receptor, NR1l2 leads to increased plasma low-density lipoprotein (LDL) cholesterol via increased PCSK9 protein expression
2277	Inhibition, aromatase activity in plasma Short Name Inhibition, plasma aromatase activity	0	Tissue	Nov 16, 2024	Nov 16, 2024	549: Aromatase inhibition leads to reproductive toxicity (including growth and developmental toxicity) in adult female zebrafish
2278	Increased LMNA Mutation Short Name LMNA Mutation	0	Molecular	Nov 20, 2024	Dec 2, 2024	550: Increased LMNA gene mutation leading to heart failure
2279	Structural changes in lamin A/C Short Name Structural changes in lamin A/C	0	Cellular	Nov 20, 2024	Nov 20, 2024	550: Increased LMNA gene mutation leading to heart failure
2280	Increased delay in heart electrical conduction Short Name Prolonged atrioventricular (AV)	0	Organ	Nov 20, 2024	Nov 26, 2024	2 AOPs 551: Increased Muscarinic M2 Receptor leading to Arrhythmia 559: Inhibition of acetylcholinesterase (AChE) leading to arrhythmias
2281	Increased uncoordinated cardiac contraction Short Name uncoordinated cardiac contraction	0	Tissue	Nov 20, 2024	Nov 26, 2024	552: Inhibiton of L-Type Calcium Channels leading to heart failure via QT interval prolongation and Torsades de Pointes (TdP)
2282	Cardiac ion channels blockade Short Name	0	Molecular	Nov 21, 2024	Nov 21, 2024	519: Cardiac ion channels blockade leading to increased incidence of cardiovascular morbidity and mortality
2283	Increased the early premature depolarizations during repolarization Short Name Early premature depolarizations	0	Cellular	Nov 21, 2024	Nov 26, 2024	2 AOPs 519: Cardiac ion channels blockade leading to increased incidence of cardiovascular morbidity and mortality 555: Inhibition, Ether-a-go-go (ERG) Voltage-Gated Potassium Channel leading to heart failure
2284	Increased Intracellular cAMP Levels Short Name Intracellular cAMP	0	Cellular	Nov 21, 2024	Nov 21, 2024	554: β-adrenergic receptor agonists leading to arrhythmias.
2285	Increased the delayed and early afterdepolarizations Short Name	0	Cellular	Nov 21, 2024	Nov 26, 2024	554: β-adrenergic receptor agonists leading to arrhythmias.
2286	Inhibition of Na⁺/K⁺-ATPase Short Name Na⁺/K⁺-ATPase	0	Molecular	Nov 21, 2024	Nov 21, 2024	None
2287	Impaired Sodium-Calcium Exchange Short Name Impaired Sodium-Calcium Exchange	0	Cellular	Nov 21, 2024	Nov 21, 2024	556: Decreased Na/K ATPase activity leading to heart failure
2288	Phosphodiesterase inhibition Short Name Phosphodiesterase (PDE)	0	Molecular	Nov 22, 2024	Nov 22, 2024	558: Phosphodiesterase inhibition leading to heart failure
2289	Hyperphosphorylation of ryanodine receptor (RyR2) Short Name RyR2 hyperphosphorylation	0	Cellular	Nov 22, 2024	Nov 22, 2024	558: Phosphodiesterase inhibition leading to heart failure
2290	Inhibition of Funny current (If) Short Name if	0	Molecular	Nov 22, 2024	Nov 22, 2024	560: Inhibition of Funny current (If) leading to Arrhythmias
2291	Slowed Heart Rate Short Name Bradycardia	0	Tissue	Nov 22, 2024	Nov 25, 2024	2 AOPs 560: Inhibition of Funny current (If) leading to Arrhythmias 562: HCN Channel Inhibition leading to Arrhythmias
2292	Altered Cardiac Electrical Conduction Short Name Altered Cardiac Electrical Conduction	0	Organ	Nov 22, 2024	Nov 22, 2024	2 AOPs 560: Inhibition of Funny current (If) leading to Arrhythmias 562: HCN Channel Inhibition leading to Arrhythmias
2293	Aromatase, induction Short Name Aromatase, induction	1	Molecular	Nov 22, 2024	Feb 21, 2025	561: Aromatase induction leading to estrogen receptor alpha activation via increased estradiol
2294	Plasma estradiol, increased Short Name Plasma E2, increased	1	Cellular	Nov 22, 2024	Jan 29, 2026	2 AOPs 561: Aromatase induction leading to estrogen receptor alpha activation via increased estradiol 623: Activation, estrogen receptor alpha leads to persistent vaginal cornification via increased kisspeptin release
2295	HCN Channel Inhibition Short Name HCN Channel Inhibition	0	Molecular	Nov 24, 2024	Nov 24, 2024	562: HCN Channel Inhibition leading to Arrhythmias
2296	Reduced Pacemaker Activity in SA Node Short Name Reduced Pacemaker Activity in SA Node	0	Cellular	Nov 24, 2024	Nov 25, 2024	562: HCN Channel Inhibition leading to Arrhythmias
2297	Serum bile acid levels, Altered Short Name Bile acid alterations	0	Cellular	Nov 25, 2024	Nov 25, 2024	None
2298	Decrease, intratesticular testosterone levels Short Name Decrease, intratesticular testosterone	1	Organ	Dec 12, 2024	Jan 27, 2025	3 AOPs 307: Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring 570: Decreased testosterone synthesis leading to hypospadias in male (mammalian) offspring 575: Decreased testosterone synthesis leading to increased nipple retention (NR) in male (rodent) offspring
2299	Altered, Redox Homeostasis Short Name Altered, Redox Homeostasis	1	Molecular	Dec 24, 2024	Jan 20, 2025	564: DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity.
2300	Disruption, Glucolipid metabolism Short Name Disruption, Glucolipid metabolism	2	Cellular	Dec 24, 2024	Jan 20, 2025	564: DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity.