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All Key Events

Showing 301 to 325 of 1939 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

2140	Decreased spawning and cumulative fecundity, decreased gonadosomatic index Short Name	0	Individual	May 16, 2023	May 16, 2023	None
2139	Reduction, the ratio of 17beta-estradiol/11-Keto Testosterone in plasma Short Name	0	Organ	May 16, 2023	May 16, 2023	496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish）
2137	Increase, Gonadotropins concentration in plasma Short Name	1	Cellular	May 16, 2023	Apr 6, 2026	5 AOPs 496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish） 623: Activation, estrogen receptor alpha leads to persistent vaginal cornification via increased kisspeptin release 637: Activation, estrogen receptor alpha leads to increased uterine weight via earlier proliferation of cells of the uterine lining 639: Activation, estrogen receptor alpha leads to precocious puberty via increased kisspeptin release 640: Activation, estrogen receptor alpha leads to decreased fertility via prolonged estrus cycle
2136	prostatic intraepithelial neoplasia Short Name prostatic intraepithelial neoplasia	0	Tissue	May 11, 2023	May 11, 2023	495: Androgen receptor activation leading to prostate cancer
2135	Prostate cancer Short Name Prostate cancer	0	Individual	May 11, 2023	May 11, 2023	495: Androgen receptor activation leading to prostate cancer
2134	Increase, Androgen receptor protein expression/abundance Short Name	0	Cellular	May 11, 2023	Dec 31, 2024	495: Androgen receptor activation leading to prostate cancer
2133	Increase, Glucuronidation of T4 Short Name Increase, Glucuronidation of T4	0	Molecular	Apr 12, 2023	Apr 12, 2023	None
2132	Increased pro-inflammatory cytokine expression Short Name Increased cytokine expression	0	Cellular	Apr 6, 2023	Apr 6, 2023	493: ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity
2131	Conjugation, GSH Short Name Conjugation, GSH	1	Cellular	Apr 5, 2023	Sep 14, 2023	492: Glutathione conjugation leading to reproductive dysfunction via oxidative stress
2130	increased lipid accumulation Short Name increased lipid accumulation	0	Cellular	Apr 5, 2023	Apr 5, 2023	493: ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity
2129	Metabolically unhealthy Obesity Short Name Metabolically unhealthy Obesity	0	Individual	Apr 5, 2023	Apr 5, 2023	493: ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity
2128	Increased adipocyte numbers Short Name Increased adipocyte numbers	0	Cellular	Apr 5, 2023	Apr 5, 2023	493: ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity
2127	Increased adipocyte size Short Name Increased adipocyte size	0	Cellular	Apr 5, 2023	Apr 5, 2023	493: ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity
2126	Estrogen receptor alpha inactivation Short Name ERa inactivation	0	Molecular	Apr 5, 2023	Apr 10, 2023	2 AOPs 493: ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity 497: ERa inactivation alters mitochondrial functions and insulin signalling in skeletal muscle and leads to insulin resistance and metabolic syndrome
2125	Increased fat mass Short Name Increased fat mass	0	Organ	Apr 5, 2023	Apr 5, 2023	493: ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity
2124	increased, Bax expression Short Name increased, Bax	1	Molecular	Apr 4, 2023	May 20, 2025	2 AOPs 490: Co-activation of IP3R and RyR leads to reduced IQ and increased socio-economic burden through non-cholinergic mechanisms 563: Aryl hydrocarbon Receptor (AHR) activation causes Premature Ovarian Insufficiency via Bax mediated apoptosis
2123	decreased, Bcl-2 expression Short Name decreased, Bcl-2	0	Molecular	Apr 4, 2023	May 29, 2025	490: Co-activation of IP3R and RyR leads to reduced IQ and increased socio-economic burden through non-cholinergic mechanisms
2122	increased, socio-economic burden Short Name increased, socio-economic burden	0	Population	Apr 4, 2023	Jun 18, 2025	490: Co-activation of IP3R and RyR leads to reduced IQ and increased socio-economic burden through non-cholinergic mechanisms
2121	decreased, Intellectual Quotient Short Name decreased, IQ	0	Population	Apr 4, 2023	May 29, 2025	2 AOPs 490: Co-activation of IP3R and RyR leads to reduced IQ and increased socio-economic burden through non-cholinergic mechanisms 569: Decreased DNA methylation of FAM50B/PTCHD3 leading to IQ loss of children via PI3K-Akt pathway
2120	Superoxide generation, increased Short Name Superoxide generation, increased	1	Cellular	Apr 3, 2023	Apr 17, 2023	457: Succinate dehydrogenase inhibition leading to increased insulin resistance through reduction in circulating thyroxine
2119	Increase, Insulin resistance Short Name Increase, Insulin resistance	1	Organ	Apr 3, 2023	Feb 11, 2026	7 AOPs 457: Succinate dehydrogenase inhibition leading to increased insulin resistance through reduction in circulating thyroxine 454: PM2.5-related AOP frameworks on liver diseases 493: ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity 497: ERa inactivation alters mitochondrial functions and insulin signalling in skeletal muscle and leads to insulin resistance and metabolic syndrome 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress
2118	Succinate dehydrogenase, inhibited Short Name SDH, inhibited	3	Molecular	Apr 3, 2023	May 4, 2023	5 AOPs 457: Succinate dehydrogenase inhibition leading to increased insulin resistance through reduction in circulating thyroxine 534: Succinate dehydrogenase (SDH) inhibition leads to oxidative stress 474: Succinate dehydrogenase inactivation leads to cancer by promoting EMT 546: Succinate dehydrogenase inactivation leads to cancer through hypoxic-like mechanisms 588: Inhibition of the mitochondrial complex II of nigro-striatal neurons leads to parkinsonian motor deficits
2117	Increase, goblet cell number Short Name Increase, goblet cell number	1	Cellular	Mar 8, 2023	Mar 8, 2023	148: EGFR Activation Leading to Decreased Lung Function
2116	Decreased, oligodendrocyte differentiation Short Name Oligodendrocyte differentiation	0	Cellular	Feb 22, 2023	Feb 22, 2023	3 AOPs 487: Unknown MIE altering cholesterol metabolism leading to decreased cognition 488: Increased reactive oxygen species production leading to decreased cognitive function 489: Inhibition of voltage-gated sodium channels leading to decreased cognition
2115	Altered, cholesterol metabolism Short Name Cholesterol metabolism	0	Molecular	Feb 22, 2023	Feb 22, 2023	2 AOPs 487: Unknown MIE altering cholesterol metabolism leading to decreased cognition 525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory