AOP-Wiki

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All Key Events

Showing 401 to 425 of 1939 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

2039	Inhibition GABAA receptor Short Name Inhibition, GABAAr	0	Molecular	Jul 25, 2022	Jul 25, 2022	464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
2038	Activation of calpain signalling Short Name Activation, calpain	0	Cellular	Jul 25, 2022	Jul 25, 2022	464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
2037	Inositol triphosphate receptor activation Short Name Activation, IP3R	0	Molecular	Jul 25, 2022	May 29, 2025	2 AOPs 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits 490: Co-activation of IP3R and RyR leads to reduced IQ and increased socio-economic burden through non-cholinergic mechanisms
2036	Activation of metabotropic glutamate receptor Short Name Activation, mGLUr	0	Molecular	Jul 25, 2022	Jul 25, 2022	464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
2035	development, liver cancer Short Name development, liver cancer	0	Tissue	Jul 21, 2022	Jul 21, 2022	None
2034	liver dysfunction Short Name liver dysfunction	0	Organ	Jul 20, 2022	Jul 20, 2022	463: The AOP framwork on silica nanopariticles induced hepatoxicity
2033	Increased sphingolipid-1-phosphate Short Name Increased S1-P	0	Cellular	Jul 19, 2022	Jul 19, 2022	449: Ceramide synthase inhibition leading to neural tube defects
2032	Viable offspring, decreased Short Name Viable offspring, decreased	0	Individual	Jul 18, 2022	Jul 18, 2022	None
2031	Releasing, Apoptosis-Inducing Factor (AIF) Short Name AIF release	0	Molecular	Jul 18, 2022	Jul 18, 2022	423: Toxicological mechanisms of hepatocyte apoptosis through the PARP1 dependent cell death pathway
2030	Activation, PARP1 Short Name PARP1	0	Molecular	Jul 18, 2022	Jul 18, 2022	423: Toxicological mechanisms of hepatocyte apoptosis through the PARP1 dependent cell death pathway
2029	protein-coupled estrogen receptor 1 (GPER) activation Short Name GPER activation	0	Molecular	Jul 18, 2022	Jul 18, 2022	2 AOPs 401: G protein-coupled estrogen receptor 1 (GPER) signal pathway in the lipid metabolism disrupting effects 535: Binding and activation of GPER leading to learning and memory impairments
2028	Decrease, GLI1/2 translocation to nucleus Short Name Decrease, GLI1/2 translocation	2	Molecular	Jul 15, 2022	Oct 28, 2022	2 AOPs 460: Antagonism of Smoothened receptor leading to orofacial clefting 502: Decrease, cholesterol synthesis leads to orofacial clefting
2027	Antagonism, Smoothened receptor Short Name Antagonism Smoothened	1	Molecular	Jul 15, 2022	Mar 25, 2025	460: Antagonism of Smoothened receptor leading to orofacial clefting
2026	decreased folate uptake Short Name decrease folate	0	Cellular	Jul 14, 2022	Jul 14, 2022	449: Ceramide synthase inhibition leading to neural tube defects
2025	Affected folate transporter Short Name Affected folate transporter	0	Cellular	Jul 14, 2022	Jul 14, 2022	449: Ceramide synthase inhibition leading to neural tube defects
2024	Reduced complex sphingolipids Short Name Reduced complex sphingolipids	0	Cellular	Jul 14, 2022	Jul 19, 2022	449: Ceramide synthase inhibition leading to neural tube defects
2023	Inhibition of Ceramide Synthase Short Name Inhibition CerS	0	Molecular	Jul 14, 2022	Jul 19, 2022	449: Ceramide synthase inhibition leading to neural tube defects
2022	Altered function of the brain Short Name brain function	0	Organ	Jul 6, 2022	Jul 6, 2022	None
2021	Increase, slincR expression Short Name Increase, slincR expression	1	Molecular	Jun 29, 2022	Aug 1, 2022	2 AOPs 455: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development 456: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity
2020	Decrease, sox9 expression Short Name Decrease, sox9 expression	1	Molecular	Jun 28, 2022	Sep 25, 2024	2 AOPs 455: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development 456: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity
2019	Non-alcoholic fatty liver disease Short Name Non-alcoholic fatty liver disease	0	Individual	Jun 27, 2022	Jun 27, 2022	2 AOPs 454: PM2.5-related AOP frameworks on liver diseases 591: DBDPE-induced DNA damage increase in liver leading to Non-alcoholic fatty liver disease via liver steatosis and inhibition of regeneration
2017	Endoplasmic reticulum stress Short Name Endoplasmic reticulum stress	0	Cellular	Jun 27, 2022	Jun 27, 2022	2 AOPs 454: PM2.5-related AOP frameworks on liver diseases 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
2016	Hepatocyte cell apoptosis Short Name Hepatocyte cell apoptosis	0	Cellular	Jun 7, 2022	Jun 7, 2022	None
2015	Intestinal inflammation Short Name Intestinal inflammation	0	Organ	Jun 6, 2022	Jun 6, 2022	None
2014	Intestinal epithelial cell apoptosis Short Name Intestinal epithelial cell apoptosis	0	Cellular	Jun 6, 2022	Jun 7, 2022	None