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All Key Events

Showing 676 to 700 of 1939 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1743	Increase plasma Ang II Short Name Increase plasma Ang II	0	Tissue	Mar 10, 2020	Mar 10, 2020	383: Inhibition of Angiotensin-converting enzyme 2 leading to liver fibrosis
1741	Induced, Angiotensin (Ang) II accumulation Short Name	0	Tissue	Mar 10, 2020	Mar 30, 2021	427: ACE2 downregulation following SARS-CoV-2 infection triggers dysregulation of RAAS and can lead to heart failure.
1740	Induced dysregulation of ACE2 Short Name ACE2 enzymatic inhibition	0	Molecular	Mar 10, 2020	Mar 3, 2022	2 AOPs 319: Binding to ACE2 leading to lung fibrosis 383: Inhibition of Angiotensin-converting enzyme 2 leading to liver fibrosis
1739	Binding to ACE2 Short Name Binding to ACE2	1	Molecular	Mar 2, 2020	Oct 21, 2024	15 AOPs 320: Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality 374: Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on brain cells (neuronal and non-neuronal) leads to neuroinflammation resulting in encephalitis 381: Binding of viral S-glycoprotein to ACE2 receptor leading to dysgeusia 385: Viral spike protein interaction with ACE2 leads to microvascular dysfunction, via ACE2 dysregulation 394: SARS-CoV-2 infection of olfactory epithelium leading to impaired olfactory function (short-term anosmia) 395: Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on pericytes leads to disseminated intravascular coagulation resulting in cerebrovascular disease (stroke) 406: SARS-CoV-2 infection leading to hyperinflammation 407: SARS-CoV-2 infection leading to pyroptosis 426: SARS-CoV-2 spike protein binding to ACE2 receptors expressed on pericytes leads to endothelial cell dysfunction, microvascular injury and myocardial infarction. 427: ACE2 downregulation following SARS-CoV-2 infection triggers dysregulation of RAAS and can lead to heart failure. 422: Binding of SARS-CoV-2 to ACE2 in enterocytes leads to intestinal barrier disruption 428: Binding of S-protein to ACE2 in enterocytes induces ACE2 dysregulation leading to gut dysbiosis 430: Binding of SARS-CoV-2 to ACE2 leads to viral infection proliferation 379: Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation 468: Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death)
1738	SARS-CoV-2 cell entry Short Name SARS-CoV-2 cell entry	4	Cellular	Mar 1, 2020	Apr 4, 2023	10 AOPs 320: Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality 379: Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation 394: SARS-CoV-2 infection of olfactory epithelium leading to impaired olfactory function (short-term anosmia) 395: Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on pericytes leads to disseminated intravascular coagulation resulting in cerebrovascular disease (stroke) 406: SARS-CoV-2 infection leading to hyperinflammation 407: SARS-CoV-2 infection leading to pyroptosis 426: SARS-CoV-2 spike protein binding to ACE2 receptors expressed on pericytes leads to endothelial cell dysfunction, microvascular injury and myocardial infarction. 422: Binding of SARS-CoV-2 to ACE2 in enterocytes leads to intestinal barrier disruption 430: Binding of SARS-CoV-2 to ACE2 leads to viral infection proliferation 468: Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death)
1725	Pancreatic acinar cell tumors Short Name Acinar cell tumors	0	Molecular	Jan 8, 2020	Jan 8, 2020	316: Trypsin inhibition leading to pancreatic acinar cell tumors
1724	Acinar cell proliferation Short Name Acinar cell proliferation	0	Cellular	Jan 8, 2020	Jan 8, 2020	316: Trypsin inhibition leading to pancreatic acinar cell tumors
1723	Increased exocrine secretion from pancreatic acinar cells Short Name	0	Cellular	Jan 8, 2020	Jan 8, 2020	316: Trypsin inhibition leading to pancreatic acinar cell tumors
1722	Increased blood CCK level Short Name Increased blood CCK level	0	Organ	Jan 8, 2020	Jan 8, 2020	316: Trypsin inhibition leading to pancreatic acinar cell tumors
1721	Increased intestinal monitor peptide level Short Name Increased monitor peptide	0	Organ	Jan 8, 2020	Jan 8, 2020	316: Trypsin inhibition leading to pancreatic acinar cell tumors
1720	Trypsin inhibition Short Name Inhibition, trypsin	0	Molecular	Jan 8, 2020	Jan 8, 2020	316: Trypsin inhibition leading to pancreatic acinar cell tumors
1719	Impairment of T-cell dependent antibody response Short Name Impairment, TDAR	1	Individual	Jan 5, 2020	Feb 24, 2021	315: Inhibition of JAK3 leading to impairment of T-Cell Dependent Antibody Response
1718	Suppression of IL-4 production Short Name Suppression of IL-4 production	1	Cellular	Jan 5, 2020	Mar 17, 2025	315: Inhibition of JAK3 leading to impairment of T-Cell Dependent Antibody Response
1717	Suppression of STAT5 binding to cytokine gene promoters Short Name	1	Cellular	Jan 5, 2020	Mar 17, 2025	315: Inhibition of JAK3 leading to impairment of T-Cell Dependent Antibody Response
1716	Blockade of STAT5 phosphorylation Short Name STAT5 inhibition	1	Cellular	Jan 5, 2020	Mar 17, 2025	315: Inhibition of JAK3 leading to impairment of T-Cell Dependent Antibody Response
1715	Inhibition of JAK3 Short Name Inhibition of JAK3	1	Molecular	Jan 5, 2020	Feb 15, 2021	315: Inhibition of JAK3 leading to impairment of T-Cell Dependent Antibody Response
1714	Exacerbation of systemic lupus erythematosus (SLE) Short Name Exacerbation of SLE	0	Individual	Dec 29, 2019	Aug 14, 2020	314: Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE)
1713	Increase of anti-DNA antibody from autoreactive B cell Short Name Increase of autoantibody production	0	Cellular	Dec 29, 2019	Aug 14, 2020	314: Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE)
1712	Increase of Th2 cells producing IL-4 Short Name Increase of Th2 cells producing IL-4	0	Cellular	Dec 29, 2019	Aug 14, 2020	314: Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE)
1711	Induction of GATA3 expression Short Name Induction of GATA3 expression	0	Cellular	Dec 29, 2019	Aug 14, 2020	314: Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE)
1710	Binding to estrogen receptor (ER)-α in immune cells Short Name Binding to estrogen receptor (ER)-α	0	Molecular	Dec 29, 2019	Aug 14, 2020	314: Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE)
1709	Psoriatic skin disease Short Name Skin disease	0	Individual	Dec 27, 2019	Nov 23, 2020	313: Stimulation of TLR7/8 in dendric cells leading to Psoriatic skin disease
1708	Th17 cell migration and inflammation induction Short Name	0	Cellular	Dec 27, 2019	Nov 23, 2020	2 AOPs 313: Stimulation of TLR7/8 in dendric cells leading to Psoriatic skin disease 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
1707	Increase, IL-23 from matured dendritic cells Short Name Increase of IL-23	0	Cellular	Dec 27, 2019	Nov 23, 2020	313: Stimulation of TLR7/8 in dendric cells leading to Psoriatic skin disease
1706	Stimulation, TLR7/8 Short Name Stimulation of TLR7/8	0	Molecular	Dec 27, 2019	Nov 21, 2020	313: Stimulation of TLR7/8 in dendric cells leading to Psoriatic skin disease