AOP-Wiki

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All Key Events

Showing 751 to 775 of 1939 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1653	Binding of inhibitor to mitochondrial complex III Short Name	0	Molecular	Jun 7, 2019	Jun 7, 2019	273: Mitochondrial complex inhibition leading to liver injury
1652	Increase, S-adenosylmethionine depletion Short Name Increase, SAM depletion	0	Molecular	May 30, 2019	May 30, 2019	None
1651	Treatment-resistant gastric cancer Short Name Resistant gastric cancer	1	Tissue	May 29, 2019	Jun 12, 2025	298: Increase in reactive oxygen species (ROS) leading to human treatment-resistant gastric cancer
1649	Snail, Zeb, Twist activation Short Name Snail, Zeb, Twist activation	0	Molecular	May 29, 2019	May 29, 2019	None
1648	β-catenin activation Short Name β-catenin activation	0	Molecular	May 29, 2019	May 29, 2019	None
1647	GSK3beta inactivation Short Name GSK3beta inactivation	0	Molecular	May 29, 2019	Oct 5, 2021	410: GSK3beta inactivation leading to increased mortality via defects in developing inner ear
1646	Frizzled activation Short Name Frizzled activation	0	Molecular	May 29, 2019	May 29, 2019	None
1645	Wnt ligand stimulation Short Name Wnt ligand stimulation	0	Molecular	May 28, 2019	May 29, 2019	None
1644	Impaired Ab production Short Name Impaired Ab production	0	Cellular	May 23, 2019	Jun 25, 2019	None
1643	Altered, Visual function Short Name Altered, Visual function	1	Organ	May 22, 2019	Jul 8, 2022	5 AOPs 297: Inhibition of retinaldehyde dehydrogenase leads to population decline 399: Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos) 363: Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure 364: Thyroperoxidase inhibition leading to altered visual function via decreased eye size 365: Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning
1642	Decreased plasma RA level Short Name plasma retinoic acid	0	Tissue	May 22, 2019	Nov 3, 2025	297: Inhibition of retinaldehyde dehydrogenase leads to population decline
1641	Decreased retinoic acid (RA) synthesis Short Name retinoic acid	0	Cellular	May 22, 2019	May 22, 2019	297: Inhibition of retinaldehyde dehydrogenase leads to population decline
1640	Altered, Photoreceptor patterning Short Name Altered, Photoreceptor patterning	0	Cellular	May 22, 2019	Jun 16, 2021	2 AOPs 297: Inhibition of retinaldehyde dehydrogenase leads to population decline 365: Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning
1639	Plasma RA level decreased Short Name Plasma RA	0	Tissue	May 22, 2019	May 22, 2019	None
1638	Retinoic acid (RA) synthesis decreased Short Name RA	0	Cellular	May 22, 2019	May 22, 2019	None
1637	Retinaldehyde dehydrogenase inhibition Short Name Retinaldehyde dehydrogenase	0	Molecular	May 22, 2019	May 22, 2019	297: Inhibition of retinaldehyde dehydrogenase leads to population decline
1636	Increase, Chromosomal aberrations Short Name Increase, Chromosomal aberrations	1	Cellular	May 19, 2019	Mar 8, 2024	4 AOPs 296: Oxidative DNA damage leading to chromosomal aberrations and mutations 272: Deposition of energy leading to lung cancer 478: Deposition of energy leading to occurrence of cataracts 644: Bulky DNA adducts leading to chromosomal aberrations and mutations
1635	Increase, DNA strand breaks Short Name Increase, DNA strand breaks	1	Molecular	May 19, 2019	Dec 17, 2024	13 AOPs 296: Oxidative DNA damage leading to chromosomal aberrations and mutations 272: Deposition of energy leading to lung cancer 322: Alkylation of DNA leading to decreased sperm count 216: Deposition of energy leading to population decline via DNA strand breaks and follicular atresia 238: Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis 478: Deposition of energy leading to occurrence of cataracts 483: Deposition of Energy Leading to Learning and Memory Impairment 470: Deposition of energy leads to abnormal vascular remodeling 592: DBDPE-induced DNA strand breaks and LDH activity inhibition leading to population growth rate decline via energy metabolism disrupt and apoptosis 602: Excessive reactive oxygen species leading to growth inhibition via oxidative DNA damage 324: Reactive oxygen species leading to growth inhibition via oxidative DNA damage and cell cycle disruption 325: Reactive oxygen species leading to growth inhibition via oxidative DNA damage and cell death 644: Bulky DNA adducts leading to chromosomal aberrations and mutations
1634	Increase, Oxidative DNA damage Short Name Increase, Oxidative DNA damage	1	Molecular	May 19, 2019	Oct 8, 2024	8 AOPs 296: Oxidative DNA damage leading to chromosomal aberrations and mutations 299: Deposition of energy leading to population decline via DNA oxidation and follicular atresia 311: Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis 478: Deposition of energy leading to occurrence of cataracts 330: Excessive reactive oxygen species production leading to mortality (4) 602: Excessive reactive oxygen species leading to growth inhibition via oxidative DNA damage 324: Reactive oxygen species leading to growth inhibition via oxidative DNA damage and cell cycle disruption 325: Reactive oxygen species leading to growth inhibition via oxidative DNA damage and cell death
1633	Increase in inflammation Short Name Increase in inflammation	0	Tissue	May 3, 2019	May 3, 2019	3 AOPs 362: Immune mediated hepatitis 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways 493: ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity
1632	Increase in reactive oxygen and nitrogen species (RONS) Short Name Increase in RONS	0	Molecular	May 3, 2019	May 8, 2019	5 AOPs 293: Increased DNA damage leading to increased risk of breast cancer 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer 432: Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability 473: Energy deposition from internalized Ra-226 decay lower oxygen binding capacity of hemocyanin
1631	Reduction fo Pigmentation pattern Short Name Reduction fo Pigmentation pattern	0	Individual	May 3, 2019	May 3, 2019	292: Inhibition of tyrosinase leads to decreased population in fish
1630	Reduction of melanosome level Short Name Reduction of melanosome level	0	Tissue	May 3, 2019	May 3, 2019	292: Inhibition of tyrosinase leads to decreased population in fish
1629	Reduction in melanin level Short Name Reduction in melanin level	0	Cellular	May 3, 2019	May 3, 2019	292: Inhibition of tyrosinase leads to decreased population in fish
1628	Reduction of L-Dopaquinone Short Name Reduction of L-Dopaquinone	0	Cellular	May 3, 2019	May 3, 2019	292: Inhibition of tyrosinase leads to decreased population in fish