AOP-Wiki

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All Key Events

Showing 801 to 825 of 1939 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1600	Eczematous eruption (Erythema, Papules, Vesicles, Pruritius, Weeping, Oozing, Crusting) Short Name Eczematous eruption	0	Organ	Feb 3, 2019	Feb 3, 2019	None
1599	Inflamatory events in light-exposed tissues Short Name Inflammatory events	0	Organ	Feb 3, 2019	Jul 4, 2019	2 AOPs 282: Adverse outcome pathway on photochemical toxicity initiated by light exposure 495: Androgen receptor activation leading to prostate cancer
1598	Formation of protein photo-adducts Short Name Protein photo-adducts	0	Cellular	Feb 3, 2019	Feb 3, 2019	None
1597	Formation of DNA photo-adducts Short Name DNA photo-adducts	0	Cellular	Feb 3, 2019	Feb 3, 2019	None
1596	Oxidation of DNA Short Name Oxidation of DNA	0	Cellular	Feb 3, 2019	Feb 3, 2019	None
1595	Oxidation/denatuation of membrane proteins Short Name	0	Cellular	Feb 3, 2019	Jul 4, 2019	282: Adverse outcome pathway on photochemical toxicity initiated by light exposure
1594	Oxidation of membrane lipids Short Name Oxidation of membrane lipids	0	Cellular	Feb 3, 2019	Jul 4, 2019	282: Adverse outcome pathway on photochemical toxicity initiated by light exposure
1593	Radicals of target chemicals Short Name Radical generation	0	Molecular	Feb 3, 2019	Feb 3, 2019	None
1591	Absorption of photon energy Short Name Absorption of photon energy	0	Molecular	Feb 3, 2019	Feb 5, 2019	None
1590	Distribution and deposition of chemicals to skin and/or eyes Short Name Distribution of chemicals	0	Molecular	Feb 3, 2019	Feb 3, 2019	None
1589	Systemic or topical administration of chemicals Short Name Administration of chemicals	0	Molecular	Feb 3, 2019	Feb 3, 2019	None
1588	Bronchiolitis obliterans Short Name Bronchiolitis obliterans	0	Individual	Jan 30, 2019	Jan 30, 2019	280: α-diketone-induced bronchiolitis obliterans
1587	Fibroproliferative airway lesions Short Name Fibroproliferative airway lesions	0	Tissue	Jan 30, 2019	Jan 30, 2019	280: α-diketone-induced bronchiolitis obliterans
1586	Airway epithelial injury Short Name Airway epithelial injury	0	Cellular	Jan 30, 2019	Jan 30, 2019	2 AOPs 280: α-diketone-induced bronchiolitis obliterans 481: AOPs of amorphous silica nanoparticles: ROS-mediated oxidative stress increased respiratory dysfunction and diseases.
1585	Proteasomal dysfunction Short Name Proteasomal dysfunction	0	Molecular	Jan 30, 2019	Jan 30, 2019	2 AOPs 280: α-diketone-induced bronchiolitis obliterans 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
1584	Interaction of α-diketones with arginine residues Short Name	0	Molecular	Jan 30, 2019	Jan 30, 2019	280: α-diketone-induced bronchiolitis obliterans
1583	Sensory axonal peripheral neuropathy Short Name Sensory axonal peripheral neuropathy	0	Individual	Jan 29, 2019	Jan 29, 2019	3 AOPs 279: Microtubule interacting drugs lead to peripheral neuropathy 450: Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality 471: Neuron defect induced early behavioral change
1582	Impaired axonial transport Short Name Impaired axonial transport	0	Cellular	Jan 29, 2019	Jan 29, 2019	3 AOPs 279: Microtubule interacting drugs lead to peripheral neuropathy 429: A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants 471: Neuron defect induced early behavioral change
1581	Disturbance in microtubule dynamic instability Short Name	0	Cellular	Jan 29, 2019	Jan 29, 2019	279: Microtubule interacting drugs lead to peripheral neuropathy
1580	Binding of microtubule stabilizing agents (MSA) to microtubules Short Name Binding of MSAs to microtubules	0	Molecular	Jan 29, 2019	Jan 29, 2019	279: Microtubule interacting drugs lead to peripheral neuropathy
1579	Increase, proinflammatory mediators (TNFalpha) Short Name	0	Molecular	Jan 7, 2019	Jan 7, 2019	278: IKK complex inhibition leading to liver injury
1578	Increase, Necrotic tissue Short Name Increase, Necrotic tissue	0	Tissue	Jan 7, 2019	Jan 7, 2019	None
1577	Increased, proinflammatory mediators (TNFalpha) Short Name	0	Molecular	Jan 7, 2019	Jan 7, 2019	None
1576	Activation, Tissue resident cells (Kuppfer cells) Short Name	0	Cellular	Jan 7, 2019	Jan 7, 2019	278: IKK complex inhibition leading to liver injury
1575	Activation, Caspase 8 pathway Short Name Activation, Caspase 8 pathway	0	Molecular	Jan 7, 2019	Mar 7, 2019	278: IKK complex inhibition leading to liver injury