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All Key Events

Showing 1351 to 1375 of 1939 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1027	, Learning and memory, impairment Short Name , Learning and memory, impairment	0		Nov 29, 2016	Nov 29, 2016	None
1026	Increased Apoptosis, Adenomas/carcinomas (follicular cell) Short Name	2	Tissue	Nov 29, 2016	Sep 16, 2017	None
1025	Increased, Hyperplasia (follicular cells) Short Name	1	Tissue	Nov 29, 2016	Sep 16, 2017	None
1024	Increased, Hypertrophy and proliferation (follicular cell) Short Name	2	Cellular	Nov 29, 2016	Sep 16, 2017	None
1023	Increased, Thyroid-stimulating hormone (TSH) Short Name	1	Tissue	Nov 29, 2016	Sep 16, 2017	4 AOPs 162: Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse 190: Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis 110: Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse) 119: Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse)
1022	Decreased, serum T4/T3 Short Name Decreased, serum T4/T3	1	Tissue	Nov 29, 2016	Sep 16, 2017	None
1021	Increased, T4/T3 catabolism Short Name Increased, T4/T3 catabolism	1	Cellular	Nov 29, 2016	Sep 16, 2017	None
1020	Increased, induction of UDPGT's in liver Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	None
1019	Induction, pharyngeal muscle paralysis Short Name Induction, pharyngeal muscle paralysis	1	Tissue	Nov 29, 2016	Sep 16, 2017	161: Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality
1018	Activation, Glutamate-gated chloride channels Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	2 AOPs 161: Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality 471: Neuron defect induced early behavioral change
1017	Reduced, Feeding 2 Short Name Reduced, Feeding 2	0		Nov 29, 2016	Nov 29, 2016	None
1016	Inhibition, Feeding Short Name Inhibition, Feeding	1	Individual	Nov 29, 2016	Jan 14, 2025	4 AOPs 161: Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality 160: Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality 471: Neuron defect induced early behavioral change 568: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) leads to Inhibition, Feeding
1015	Increased, Neuronal synaptic inhibition Short Name Increased, Neuronal synaptic inhibition	1	Cellular	Nov 29, 2016	Sep 16, 2017	3 AOPs 161: Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality 160: Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality 471: Neuron defect induced early behavioral change
1014	Induction, Somatic muscle paralysis Short Name Induction, Somatic muscle paralysis	1	Tissue	Nov 29, 2016	Sep 16, 2017	2 AOPs 160: Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality 471: Neuron defect induced early behavioral change
1013	Inhibition, Motor neuron activity Short Name Inhibition, Motor neuron activity	0		Nov 29, 2016	Nov 29, 2016	None
1012	Increased, Inhibitory postsynaptic potential Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	3 AOPs 160: Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality 161: Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality 471: Neuron defect induced early behavioral change
1011	Increased, Chloride influx Short Name Increased, Chloride influx	0		Nov 29, 2016	Nov 29, 2016	None
1009	Inhibition, Deiodinase 1 Short Name Inhibition, Deiodinase 1	1	Molecular	Nov 29, 2016	Nov 18, 2025	3 AOPs 157: Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation 158: Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation 189: Type I iodothyronine deiodinase (DIO1) inhibition leading to altered amphibian metamorphosis
1008	Reduced, Hearing Short Name Reduced, Hearing	1	Organ	Nov 29, 2016	Feb 18, 2019	410: GSK3beta inactivation leading to increased mortality via defects in developing inner ear
1007	Reduced, Anterior swim bladder inflation Short Name	1	Organ	Nov 29, 2016	Oct 7, 2022	3 AOPs 156: Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation 158: Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation 159: Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation
1005	Reduced, Swimming performance Short Name Reduced, Swimming performance	1	Individual	Nov 29, 2016	Sep 8, 2021	10 AOPs 155: Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation 156: Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation 157: Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation 158: Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation 159: Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation 242: Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity 334: Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration 605: Thyroid Peroxidase Inhibition Leading to Reduced, Swimming Performance via Hypomyelination 608: Thyroid Hormone Excess Leading to Reduced, Swimming Performance via Hypomyelination 611: Behavioral abnormalities due to increased expression of dopamine transporter and receptor-related genes
1004	Reduced, Posterior swim bladder inflation Short Name	1	Organ	Nov 29, 2016	Oct 7, 2022	2 AOPs 155: Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation 157: Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation
1003	Decreased, Triiodothyronine (T3) Short Name Decreased, Triiodothyronine (T3)	1	Tissue	Nov 29, 2016	Oct 7, 2022	10 AOPs 155: Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation 156: Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation 157: Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation 158: Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation 189: Type I iodothyronine deiodinase (DIO1) inhibition leading to altered amphibian metamorphosis 159: Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation 363: Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure 364: Thyroperoxidase inhibition leading to altered visual function via decreased eye size 365: Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning 605: Thyroid Peroxidase Inhibition Leading to Reduced, Swimming Performance via Hypomyelination
1002	Inhibition, Deiodinase 2 Short Name Inhibition, Deiodinase 2	1	Molecular	Nov 29, 2016	Nov 19, 2025	4 AOPs 155: Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation 156: Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation 190: Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
1001	Increased, Developmental Defects Short Name Increased, Developmental Defects	1	Molecular	Nov 29, 2016	Aug 31, 2023	43: Disruption of VEGFR Signaling Leading to Developmental Defects