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All Key Events

Showing 151 to 175 of 1939 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

2291	Slowed Heart Rate Short Name Bradycardia	0	Tissue	Nov 22, 2024	Nov 25, 2024	2 AOPs 560: Inhibition of Funny current (If) leading to Arrhythmias 562: HCN Channel Inhibition leading to Arrhythmias
2290	Inhibition of Funny current (If) Short Name if	0	Molecular	Nov 22, 2024	Nov 22, 2024	560: Inhibition of Funny current (If) leading to Arrhythmias
2289	Hyperphosphorylation of ryanodine receptor (RyR2) Short Name RyR2 hyperphosphorylation	0	Cellular	Nov 22, 2024	Nov 22, 2024	558: Phosphodiesterase inhibition leading to heart failure
2288	Phosphodiesterase inhibition Short Name Phosphodiesterase (PDE)	0	Molecular	Nov 22, 2024	Nov 22, 2024	558: Phosphodiesterase inhibition leading to heart failure
2287	Impaired Sodium-Calcium Exchange Short Name Impaired Sodium-Calcium Exchange	0	Cellular	Nov 21, 2024	Nov 21, 2024	556: Decreased Na/K ATPase activity leading to heart failure
2286	Inhibition of Na⁺/K⁺-ATPase Short Name Na⁺/K⁺-ATPase	0	Molecular	Nov 21, 2024	Nov 21, 2024	None
2285	Increased the delayed and early afterdepolarizations Short Name	0	Cellular	Nov 21, 2024	Nov 26, 2024	554: β-adrenergic receptor agonists leading to arrhythmias.
2284	Increased Intracellular cAMP Levels Short Name Intracellular cAMP	0	Cellular	Nov 21, 2024	Nov 21, 2024	554: β-adrenergic receptor agonists leading to arrhythmias.
2283	Increased the early premature depolarizations during repolarization Short Name Early premature depolarizations	0	Cellular	Nov 21, 2024	Nov 26, 2024	2 AOPs 519: Cardiac ion channels blockade leading to increased incidence of cardiovascular morbidity and mortality 555: Inhibition, Ether-a-go-go (ERG) Voltage-Gated Potassium Channel leading to heart failure
2282	Cardiac ion channels blockade Short Name	0	Molecular	Nov 21, 2024	Nov 21, 2024	519: Cardiac ion channels blockade leading to increased incidence of cardiovascular morbidity and mortality
2281	Increased uncoordinated cardiac contraction Short Name uncoordinated cardiac contraction	0	Tissue	Nov 20, 2024	Nov 26, 2024	552: Inhibiton of L-Type Calcium Channels leading to heart failure via QT interval prolongation and Torsades de Pointes (TdP)
2280	Increased delay in heart electrical conduction Short Name Prolonged atrioventricular (AV)	0	Organ	Nov 20, 2024	Nov 26, 2024	2 AOPs 551: Increased Muscarinic M2 Receptor leading to Arrhythmia 559: Inhibition of acetylcholinesterase (AChE) leading to arrhythmias
2279	Structural changes in lamin A/C Short Name Structural changes in lamin A/C	0	Cellular	Nov 20, 2024	Nov 20, 2024	550: Increased LMNA gene mutation leading to heart failure
2278	Increased LMNA Mutation Short Name LMNA Mutation	0	Molecular	Nov 20, 2024	Dec 2, 2024	550: Increased LMNA gene mutation leading to heart failure
2277	Inhibition, aromatase activity in plasma Short Name Inhibition, plasma aromatase activity	0	Tissue	Nov 16, 2024	Nov 16, 2024	549: Aromatase inhibition leads to reproductive toxicity (including growth and developmental toxicity) in adult female zebrafish
2276	Increased, protein expression of proprotein convertase subtilisin/kexin type 9 (PCSK9) Short Name Increased, PCSK9 protein expression	1	Cellular	Nov 13, 2024	Feb 10, 2025	548: Activation, Pregnane-X receptor, NR1I2 leads to increased plasma low-density lipoprotein (LDL) cholesterol via increased PCSK9 protein expression
2275	Gluten reactive adaptive T-cells with antigen presenting cells, co-localization Short Name	2	Cellular	Nov 12, 2024	Dec 20, 2024	524: Gluten-driven immune activation leading to celiac disease in genetically predisposed individuals
2274	Androgen receptor activation, increased Short Name Androgen receptor activation, increased	1	Tissue	Nov 2, 2024	Nov 2, 2024	547: Androgen receptor agonism leading to long anogenital distance in female offspring
2273	Dihydrotestosterone (DHT) levels, increased Short Name	1	Tissue	Nov 2, 2024	Nov 2, 2024	None
2272	Testosterone levels, increased Short Name Testosterone levels, increased	1	Tissue	Nov 2, 2024	Nov 2, 2024	None
2271	Increased, plasma low-density lipoprotein (LDL) cholesterol Short Name Increased, plasma LDL cholesterol	1	Tissue	Oct 22, 2024	Feb 10, 2025	2 AOPs 545: Activation, Pregnane-X receptor, NR1I2 leads to increased plasma low-density lipoprotein (LDL) cholesterol via increased cholesterol synthesis 548: Activation, Pregnane-X receptor, NR1I2 leads to increased plasma low-density lipoprotein (LDL) cholesterol via increased PCSK9 protein expression
2270	Increased, cholesterol synthesis enzymes Short Name	1	Cellular	Oct 22, 2024	Feb 10, 2025	545: Activation, Pregnane-X receptor, NR1I2 leads to increased plasma low-density lipoprotein (LDL) cholesterol via increased cholesterol synthesis
2269	Increased, Sterol Regulatory Element Binding Protein 2 (SREBP2) protein expression Short Name Increased, SREBP2 protein expression	1	Cellular	Oct 22, 2024	Feb 10, 2025	2 AOPs 545: Activation, Pregnane-X receptor, NR1I2 leads to increased plasma low-density lipoprotein (LDL) cholesterol via increased cholesterol synthesis 548: Activation, Pregnane-X receptor, NR1I2 leads to increased plasma low-density lipoprotein (LDL) cholesterol via increased PCSK9 protein expression
2268	Decreased, insulin-induced gene 1 (INSIG1) protein activity Short Name Decreased, INSIG1 protein activity	1	Cellular	Oct 22, 2024	Feb 10, 2025	2 AOPs 545: Activation, Pregnane-X receptor, NR1I2 leads to increased plasma low-density lipoprotein (LDL) cholesterol via increased cholesterol synthesis 548: Activation, Pregnane-X receptor, NR1I2 leads to increased plasma low-density lipoprotein (LDL) cholesterol via increased PCSK9 protein expression
2267	Delayed neuropathy, increased Short Name Delayed neuropathy, increased	0	Individual	Oct 1, 2024	Oct 1, 2024	2 AOPs 543: Inhibition of neuropathy target esterase leading to delayed neuropathy via lysolecithin cell membrane integration 544: Inhibition of neuropathy target esterase leading to delayed neuropathy via increased inflammation