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Showing 451 to 475 of 1907 Key Events

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ID Title Event Component Count Biological Organization Created At Last Updated AOPs
824 Occurrence, Cytoplasmic vacuolization (podocyte)
1 Organ Nov 29, 2016 Sep 16, 2017 128: Kidney dysfunction by decreased thyroid hormone
825 Decreased, Renal ability to dilute urine
1 Organ Nov 29, 2016 Dec 3, 2016 128: Kidney dysfunction by decreased thyroid hormone
826 Activation, Keratinocytes
2 Cellular Nov 29, 2016 Sep 16, 2017 40: Covalent Protein binding leading to Skin Sensitisation
827 sensitisation, skin
0 Organ Nov 29, 2016 Nov 29, 2016 40: Covalent Protein binding leading to Skin Sensitisation
828 Inhibition, Phospholipase A
1 Molecular Nov 29, 2016 Dec 3, 2016 130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
829 Damage, Lipid bilayer
1 Cellular Nov 29, 2016 Dec 3, 2016 130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
831 Disturbance, Lysosomal function
1 Cellular Nov 29, 2016 Sep 16, 2017
833 Occurrence, Cytoplasmic vacuolization (hepatocyte)
1 Cellular Nov 29, 2016 Sep 16, 2017 130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
835 Occurrence, Ballooning degeneration (hepatocyte)
1 Cellular Nov 29, 2016 Sep 16, 2017 130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
836 Occurrence, Cytoplasmic vacuolization (Bile duct cell)
1 Cellular Nov 29, 2016 Sep 16, 2017 130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
837 Occurrence, Cytoplasmic vacuolization (kupffer cell)
1 Cellular Nov 29, 2016 Sep 16, 2017 130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
838 Induction, Microvesicular fat
1 Tissue Nov 29, 2016 Dec 3, 2016 130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
839 Formation, Mallory body
1 Cellular Nov 29, 2016 Dec 3, 2016 130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
840 Formation, Liver fibrosis
1 Tissue Nov 29, 2016 Sep 16, 2017 130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
844 Oxidation, Uroporphyrinogen
1 Cellular Nov 29, 2016 Sep 16, 2017 131: Aryl hydrocarbon receptor activation leading to uroporphyria
845 Inhibition, UROD
1 Molecular Nov 29, 2016 May 30, 2018 131: Aryl hydrocarbon receptor activation leading to uroporphyria
846 Accumulation, Highly carboxylated porphyrins
1 Organ Nov 29, 2016 May 7, 2018 131: Aryl hydrocarbon receptor activation leading to uroporphyria
848 Decreased, Binding of NE to NE receptors on GnRH neurons
1 Cellular Nov 29, 2016 Sep 16, 2017 126: Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation
849 Inhibition, Antgonism of NE receptor
1 Molecular Nov 29, 2016 Dec 3, 2016 126: Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation
850 Induction, CYP1A2/CYP1A5
2 Molecular Nov 29, 2016 May 30, 2018
851 Decrease of GABAergic interneurons
1 Cellular Nov 29, 2016 Apr 4, 2019
853 Changes/Inhibition, Cellular Homeostasis and Apoptosis
2 Cellular Nov 29, 2016 Sep 16, 2017 41: Sustained AhR Activation leading to Rodent Liver Tumours
854 Alterations, Cellular proliferation / hyperplasia
3 Tissue Nov 29, 2016 Sep 16, 2017
856 Formation, Hepatocellular and Bile duct tumors
2 Organ Nov 29, 2016 Sep 16, 2017 41: Sustained AhR Activation leading to Rodent Liver Tumours
857 Binding as antagonist, Antagonist binding to PPARalpha ligand binding domain
0 Molecular Nov 29, 2016 Nov 29, 2016 None