AOP-Wiki

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All Key Events

Showing 951 to 975 of 1907 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1402	Reduced, PTGS1 function Short Name Reduced, PTGS1 function	0	Molecular	Jun 2, 2017	Jun 2, 2017	227: NSAID induced PTGS1 inactivation to gastric ulcer
1403	Reduced, platelet aggregation Short Name Reduced, platelet aggregation	0	Tissue	Jun 2, 2017	Jun 2, 2017	227: NSAID induced PTGS1 inactivation to gastric ulcer
1404	Decreased, mucosal blood flow Short Name Decreased, mucosal blood flow	0	Tissue	Jun 2, 2017	Jun 2, 2017	227: NSAID induced PTGS1 inactivation to gastric ulcer
1405	Reduced, mucosal defense Short Name Reduced, mucosal defense	0	Tissue	Jun 2, 2017	Jun 2, 2017	2 AOPs 227: NSAID induced PTGS1 inactivation to gastric ulcer 229: Helicobacter pylori to gastric ulcer
1406	Decreased, mucous Short Name Decreased, mucous	0	Tissue	Jun 2, 2017	Jun 2, 2017	227: NSAID induced PTGS1 inactivation to gastric ulcer
1407	Decreased, bicarbonate Short Name Decreased, bicarbonate	0	Tissue	Jun 2, 2017	Jun 2, 2017	227: NSAID induced PTGS1 inactivation to gastric ulcer
1408	Reduced, PTGS2 function Short Name Reduced, PTGS2 function	0	Cellular	Jun 2, 2017	Jun 2, 2017	228: NSAID induced PTGS2 inactivation to gastric ulcer
1409	Decreased, angiogenesis Short Name Decreased, angiogenesis	0	Tissue	Jun 2, 2017	Jun 2, 2017	228: NSAID induced PTGS2 inactivation to gastric ulcer
1410	Increased, leukocyte adherence Short Name Increased, leukocyte adherence	0	Tissue	Jun 2, 2017	Jun 2, 2017	228: NSAID induced PTGS2 inactivation to gastric ulcer
1411	Increased, leukocyte activation Short Name Increased, leukocyte activation	0	Tissue	Jun 2, 2017	Jun 2, 2017	228: NSAID induced PTGS2 inactivation to gastric ulcer
1412	Helicobacter pylori infection Short Name Helicobacter pylori infection	0	Tissue	Jun 2, 2017	Jun 2, 2017	229: Helicobacter pylori to gastric ulcer
1413	Reduced, presynaptic neuron 2 activity Short Name Reduced, presynaptic neuron 2 activity	0	Cellular	Jun 2, 2017	Jun 2, 2017	231: presynaptic neuron 2 repression to epilepsy
1414	Decreased, GABA Short Name Decreased, GABA	0	Cellular	Jun 2, 2017	Jun 2, 2017	231: presynaptic neuron 2 repression to epilepsy
1415	Reduced, GABA-A receptor activation Short Name Reduced, GABA-A receptor activation	0	Molecular	Jun 2, 2017	Jun 2, 2017	231: presynaptic neuron 2 repression to epilepsy
1416	Decreased, intracellular chloride Short Name Decreased, intracellular chloride	0	Cellular	Jun 2, 2017	Jun 2, 2017	231: presynaptic neuron 2 repression to epilepsy
1417	NFE2/Nrf2 repression Short Name NFE2/Nrf2 repression	0	Molecular	Jun 2, 2017	Jun 2, 2017	5 AOPs 232: NFE2/Nrf2 repression to steatosis 507: Nrf2 inhibition leading to vascular disrupting effects via inflammation pathway 508: Nrf2 inhibition leading to vascular disrupting effects through activating HIF1α, Semaphorin 6A, and Dll4-Notch pathway 509: Nrf2 inhibition leading to vascular disrupting effects through activating apoptosis signal pathway and mitochondrial dysfunction 615: Suppression of Keap1 cysteine oxidation leading to liver inflammation
1419	Reduced, FXR activity Short Name Reduced, FXR activity	0	Molecular	Jun 2, 2017	Jun 2, 2017	232: NFE2/Nrf2 repression to steatosis
1420	Reduced, SHP activity Short Name Reduced, SHP activity	0	Molecular	Jun 2, 2017	Jun 2, 2017	232: NFE2/Nrf2 repression to steatosis
1421	Activated, LXR Short Name Activated, LXR	0	Molecular	Jun 2, 2017	Jun 2, 2017	232: NFE2/Nrf2 repression to steatosis
1422	Reduced, PPARalpha Short Name Reduced, PPARalpha	0	Molecular	Jun 2, 2017	Jun 2, 2017	232: NFE2/Nrf2 repression to steatosis
1423	Reduced, HSD17B4 activity Short Name Reduced, HSD17B4 activity	0	Molecular	Jun 2, 2017	Jun 2, 2017	232: NFE2/Nrf2 repression to steatosis
1424	Reduced, fatty acid beta oxidation Short Name Reduced, fatty acid beta oxidation	0	Molecular	Jun 2, 2017	Jun 2, 2017	232: NFE2/Nrf2 repression to steatosis
1425	Mu Opioid Receptor Agonism Short Name Mu Opioid Receptor Agonism	0	Molecular	Jun 8, 2017	Jun 8, 2017	2 AOPs 233: Mu Opioid Receptor Agonism leading to Analgesia via K Channel Opening 234: Mu Opioid Receptor Agonism leading to Analgesia via Ca Channel Inhibition
1426	Release of G Proteins Short Name Release of G Proteins	0	Cellular	Jun 8, 2017	Jun 8, 2017	4 AOPs 233: Mu Opioid Receptor Agonism leading to Analgesia via K Channel Opening 234: Mu Opioid Receptor Agonism leading to Analgesia via Ca Channel Inhibition 235: Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via K Channel Opening 236: Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via Ca Channel Inhibition
1427	Opening of G protein gated inward rectifying K channels Short Name Opening of GIRK channels	0	Cellular	Jun 8, 2017	Jun 8, 2017	2 AOPs 233: Mu Opioid Receptor Agonism leading to Analgesia via K Channel Opening 235: Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via K Channel Opening