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All Key Events

Showing 1401 to 1425 of 1907 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1893	increase, Preeclampsia Short Name increase, Preeclampsia	0	Individual	May 31, 2021	May 31, 2021	151: AhR activation leading to preeclampsia
1894	chronic low grade systemic inflammation Short Name low grade inflammation	0	Individual	Jun 24, 2021	Jun 24, 2021	None
1895	NLRP3 inflammasome activity, increased Short Name inflammasome activity, increased	1	Molecular	Jun 25, 2021	Jun 25, 2021	3 AOPs 406: SARS-CoV-2 infection leading to hyperinflammation 407: SARS-CoV-2 infection leading to pyroptosis 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
1896	Genomic instability Short Name Genomic instability	1	Cellular	Jul 6, 2021	Jan 3, 2025	2 AOPs 409: Frustrated phagocytosis leads to malignant mesothelioma 503: Activation of uterine estrogen receptor-alfa leading to endometrial adenocarcinoma, via epigenetic modulation
1897	increased MyD88 activation Short Name MyD88 activation	0	Molecular	Jul 8, 2021	Jul 8, 2021	377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
1898	Increase, Damage-associated molecular pattern release Short Name Increase, DAMP release	0	Tissue	Jul 8, 2021	Feb 10, 2026	377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
1899	formation of neutrophil extracellular traps (NETs) Short Name NETosis	0	Cellular	Jul 8, 2021	Jul 8, 2021	377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
1900	increased platelet surface TLR9 expression Short Name increased platelet tlr9 expression	0	Cellular	Jul 8, 2021	Jul 8, 2021	377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
1901	Interferon-I antiviral response, antagonized by SARS-CoV-2 Short Name IFN-I response, antagonized	3	Cellular	Jul 9, 2021	Dec 15, 2023	5 AOPs 430: Binding of SARS-CoV-2 to ACE2 leads to viral infection proliferation 422: Binding of SARS-CoV-2 to ACE2 in enterocytes leads to intestinal barrier disruption 320: Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality 379: Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation 468: Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death)
1902	Repression of Gbx2 expression Short Name Repression of Gbx2 expression	0	Molecular	Jul 14, 2021	Oct 7, 2021	410: GSK3beta inactivation leading to increased mortality via defects in developing inner ear
1903	foxi1 expression, increased Short Name foxi1 expression, increased	0	Molecular	Jul 14, 2021	Oct 28, 2021	410: GSK3beta inactivation leading to increased mortality via defects in developing inner ear
1904	six1b expression, increased Short Name six1b expression, increased	0	Molecular	Jul 14, 2021	Aug 12, 2021	410: GSK3beta inactivation leading to increased mortality via defects in developing inner ear
1905	eya1 expression, inhibited Short Name eya1 expression, inhibited	0	Molecular	Jul 14, 2021	Oct 7, 2021	410: GSK3beta inactivation leading to increased mortality via defects in developing inner ear
1906	Cystic Fibrosis Transmembrane Regulator Function, Decreased Short Name CFTR Function, Decreased	1	Molecular	Jul 19, 2021	Aug 3, 2021	424: Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction
1907	Airway Surface Liquid Height, Decreased Short Name ASL Height, Decreased	1	Tissue	Jul 19, 2021	Sep 9, 2021	424: Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction
1908	Cilia Beat Frequency, Decreased Short Name CBF, Decreased	1	Cellular	Jul 19, 2021	Sep 10, 2021	3 AOPs 411: Oxidative stress Leading to Decreased Lung Function 424: Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction 425: Oxidative Stress Leading to Decreased Lung Function via Decreased FOXJ1
1909	Mucociliary Clearance, Decreased Short Name MCC, Decreased	1	Individual	Jul 19, 2021	Sep 10, 2021	3 AOPs 411: Oxidative stress Leading to Decreased Lung Function 424: Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction 425: Oxidative Stress Leading to Decreased Lung Function via Decreased FOXJ1
1910	Mucus Viscosity, Increased Short Name Mucus Viscosity, Increased	1	Organ	Jul 19, 2021	Sep 9, 2021	None
1911	FOXJ1 Protein, Decreased Short Name FOXJ1 Protein, Decreased	1	Cellular	Jul 23, 2021	Sep 10, 2021	425: Oxidative Stress Leading to Decreased Lung Function via Decreased FOXJ1
1912	Motile Cilia Number/Length, Decreased Short Name Motile Cilia Number/Length, Decreased	1	Cellular	Jul 23, 2021	Sep 10, 2021	425: Oxidative Stress Leading to Decreased Lung Function via Decreased FOXJ1
1913	Endothelial cell dysfunction Short Name Endothelial cell dysfunction	0	Cellular	Aug 4, 2021	Aug 4, 2021	2 AOPs 412: Endothelial cell dysfunction leading to thromboinflammation 426: SARS-CoV-2 spike protein binding to ACE2 receptors expressed on pericytes leads to endothelial cell dysfunction, microvascular injury and myocardial infarction.
1914	Platelet activation, Increased Short Name Platelet activation, Increased	0	Cellular	Aug 4, 2021	Aug 4, 2021	412: Endothelial cell dysfunction leading to thromboinflammation
1915	Neutrophil activation, Increased Short Name Neutrophil activation, Increased	0	Cellular	Aug 4, 2021	Aug 4, 2021	412: Endothelial cell dysfunction leading to thromboinflammation
1916	Thromboinflammation, Increased Short Name Thromboinflammation, Increased	0	Organ	Aug 4, 2021	Aug 4, 2021	412: Endothelial cell dysfunction leading to thromboinflammation
1917	Altered gene expression, NRF2 dependent antioxidant pathway Short Name	0	Molecular	Aug 17, 2021	Aug 19, 2021	3 AOPs 421: PPARG activation leading to intrahepatic cholestasis 420: Aryl hydrocarbon receptor activation leading to lung cancer through sustained NRF2 toxicity pathway 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways