AOP-Wiki

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All Key Events

Showing 1876 to 1900 of 1907 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

2381	Increase, transcription of the dopamine receptor (drd) gene. Short Name Increase, dopamine receptor gene	0	Molecular	Oct 19, 2025	Oct 19, 2025	611: Behavioral abnormalities due to increased expression of dopamine transporter and receptor-related genes
2382	Increase, nerve spasm Short Name Increase, nerve spasm	0	Individual	Oct 20, 2025	Oct 20, 2025	611: Behavioral abnormalities due to increased expression of dopamine transporter and receptor-related genes
2383	Increase, Hemopericardium Short Name Increase, Hemopericardium	0	Organ	Oct 29, 2025	Oct 29, 2025	3 AOPs 612: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via reduced adenosine triphosphate 613: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via increased reactive oxygen species production 614: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via reduced vascular endothelial growth factor
2384	Decrease, Vascular integrity Short Name Decrease, Vascular integrity	1	Tissue	Oct 29, 2025	Nov 7, 2025	2 AOPs 612: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via reduced adenosine triphosphate 613: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via increased reactive oxygen species production
2385	Suppression of Keap1 cysteine oxidation Short Name Suppression of Keap1 cysteine oxidation	0	Molecular	Nov 4, 2025	Nov 4, 2025	615: Suppression of Keap1 cysteine oxidation leading to liver inflammation
2386	Lipid-peroxidation overload Short Name Lipid-peroxidation overload	0	Cellular	Nov 4, 2025	Nov 4, 2025	None
2387	MIE-A: Direct ligand interaction with nuclear hormone receptors (ERα/ERβ, AR) or interference with steroidogenic enzymes (e.g., CYP19A1) → receptor activation/antagonism or enzyme inhibition. Short Name	0	Molecular	Nov 7, 2025	Nov 7, 2025	616: organic UV filter and its Photoproducts reproductive toxicity pathways
2388	MIE-B: Photoactivation / photoproduct formation leading to ROS generation Short Name photoproducts generate ROS	0	Molecular	Nov 7, 2025	Nov 7, 2025	616: organic UV filter and its Photoproducts reproductive toxicity pathways
2389	KE1: Altered steroidogenesis (gene/protein level) Short Name Altered steroidogenesis	0	Cellular	Nov 7, 2025	Nov 7, 2025	616: organic UV filter and its Photoproducts reproductive toxicity pathways
2390	KE5: Altered circulating reproductive hormones Short Name reproductive hormonal Imbalance	0	Organ	Nov 7, 2025	Nov 7, 2025	616: organic UV filter and its Photoproducts reproductive toxicity pathways
2391	Reduced fertility / fecundity Short Name Reduced fertility	0	Individual	Nov 7, 2025	Nov 7, 2025	616: organic UV filter and its Photoproducts reproductive toxicity pathways
2392	Depression Short Name Depression	0	Individual	Nov 9, 2025	Nov 10, 2025	None
2393	Androgen receptor nuclear transcriptional activity in genital-tubercle tissues, reduced Short Name	2	Cellular	Dec 3, 2025	Dec 18, 2025	619: Androgen receptor antagonism leads to delayed preputial seperation via reduced fibroblast growth factor in genital-tubercle tissues
2394	Diminished survival of naive B lymphocytes Short Name Lower survival B lymphocytes	0	Cellular	Dec 3, 2025	Dec 3, 2025	618: PPARgamma activation leads to a diminished vaccine response
2395	Diminished proliferation of activated B lymphocytes Short Name	0	Cellular	Dec 3, 2025	Dec 3, 2025	618: PPARgamma activation leads to a diminished vaccine response
2396	Diminished differentiation of activated B lymphocytes Short Name	0	Cellular	Dec 3, 2025	Dec 3, 2025	618: PPARgamma activation leads to a diminished vaccine response
2397	Diminished vaccine response Short Name Diminished vaccine response	0	Individual	Dec 3, 2025	Dec 3, 2025	618: PPARgamma activation leads to a diminished vaccine response
2398	Reduced antibody production Short Name Reduced antibody production	0	Cellular	Dec 3, 2025	Dec 3, 2025	618: PPARgamma activation leads to a diminished vaccine response
2399	Fibroblast growth factor 10, fibroblast growth factor receptor 2 isoform IIIb signaling in genital tissue, reduced Short Name	4	Cellular	Dec 11, 2025	Dec 18, 2025	619: Androgen receptor antagonism leads to delayed preputial seperation via reduced fibroblast growth factor in genital-tubercle tissues
2400	Preputial epithelial morphogenesis, disrupted Short Name	1	Cellular	Dec 15, 2025	Dec 18, 2025	619: Androgen receptor antagonism leads to delayed preputial seperation via reduced fibroblast growth factor in genital-tubercle tissues
2401	Male preputial separation, failed/delayed Short Name Male PPS, failed/delayed	2	Tissue	Dec 15, 2025	Feb 6, 2026	619: Androgen receptor antagonism leads to delayed preputial seperation via reduced fibroblast growth factor in genital-tubercle tissues
2402	Increased, estradiol (E2) production in ovaries Short Name Increased, E2 production in ovaries	1	Tissue	Jan 29, 2026	Jan 29, 2026	623: Activation, estrogen receptor alpha leads to persistent vaginal cornification via increased kisspeptin release
2403	Metabolic impairment Short Name Metabolic impairment	0	Cellular	Feb 6, 2026	Feb 6, 2026	622: Calcineurin inhibitor induced nephrotoxicity leading to kidney failure
2404	Increase, kidney fibrosis Short Name Increase, kidney fibrosis	0	Tissue	Feb 6, 2026	Feb 27, 2026	622: Calcineurin inhibitor induced nephrotoxicity leading to kidney failure
2405	Increase, Hepatocellular lipotoxicity Short Name Increase, Hepatocellular lipotoxicity	0	Cellular	Feb 10, 2026	Feb 10, 2026	6 AOPs 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress 627: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction 628: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress 629: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress