Prototypical Stressors

Showing 326 to 350 of 853 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

452	Estrogen		None
360	Ethanol	Ethanol, CAS-RN: 64-17-5, DTXSID9020584	2 AOPs 260: CYP2E1 activation and formation of protein adducts leading to neurodegeneration 436: Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries
154	Ethyl acetate	Ethyl acetate, CAS-RN: 141-78-6, DTXSID1022001	None
737	Ethyl alcohol		443: DNA damage and mutations leading to Metastatic Breast Cancer
22	Ethyl methanesulfonate	Ethyl methanesulfonate, CAS-RN: 62-50-0, DTXSID6025309	550: Increased LMNA gene mutation leading to heart failure
23	Ethyl nitrosourea	1-Ethyl-1-nitrosourea, CAS-RN: 759-73-9, DTXSID8020593	None
651	Ethyl Parathion		2 AOPs 405: Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function 450: Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality
24	Ethyl-N'-nitro-N-nitrosoguanidine	N′-Ethyl-N-nitro-N-nitrosoguanidine, CAS-RN: 63885-23-4, DTXSID3020592	None
25	Ethylene thiourea	Ethylene thiourea, CAS-RN: 96-45-7, DTXSID5020601	271: Inhibition of thyroid peroxidase leading to impaired fertility in fish
56	Ethylenethiourea	Ethylene thiourea, CAS-RN: 96-45-7, DTXSID5020601	None
576	Etomidate	Etomidate, CAS-RN: 33125-97-2, DTXSID5023033	349: Inhibition of 11β-hydroxylase leading to decresed population trajectory
223	Etoposide	Etoposide, CAS-RN: 33419-42-0, DTXSID5023035	202: Inhibitor binding to topoisomerase II leading to infant leukaemia
281	etoposide quinone		202: Inhibitor binding to topoisomerase II leading to infant leukaemia
598	Exemestane	Exemestane, CAS-RN: 107868-30-4, DTXSID5023037	346: Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation
26	Fadrozole	Fadrozole, CAS-RN: 102676-47-1, DTXSID5034141	3 AOPs 153: Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats 346: Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation 25: Aromatase inhibition leading to reproductive dysfunction
384	Felodipine	Felodipine, CAS-RN: 72509-76-3, DTXSID4023042	261: L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility
563	Fenitrothion	Fenitrothion, CAS-RN: 122-14-5, DTXSID4032613	None
211	Fenofibrate	Fenofibrate, CAS-RN: 49562-28-9, DTXSID2029874	2 AOPs 37: PPARα activation leading to hepatocellular adenomas and carcinomas in rodents 323: PPARalpha Agonism Leading to Decreased Viable Offspring via Decreased 11-Ketotestosterone
213	fenoxycarb	Fenoxycarb, CAS-RN: 72490-01-8, DTXSID7032393	201: Juvenile hormone receptor agonism leading to male offspring induction associated population decline
418	Fenpyroximate	Fenpyroximate, CAS-RN: 134098-61-6, DTXSID7032557	3: Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits
311	Ferbam	Ferbam, CAS-RN: 14484-64-1, DTXSID8020624	242: Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
571	ferric nitrilotriacetate		298: Increase in reactive oxygen species (ROS) leading to human treatment-resistant gastric cancer
145	Finasteride		3 AOPs 305: 5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring 576: 5α-reductase inhibition leading to increased nipple retention (NR) in male (rodent) offspring 571: 5α-reductase inhibition leading to hypospadias in male (mammalian) offspring
441	finasteride, dutasteride, epristeride		289: Inhibition of 5α-reductase leading to impaired fecundity in female fish
111	Fipronil	Fipronil, CAS-RN: 120068-37-3, DTXSID4034609	10: Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain