Prototypical Stressors

Showing 576 to 600 of 871 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

424	Oligomycin	Oligomycin, CAS-RN: 1404-19-9, DTXSID7040570	None
399	Oligomycin A, Aurovertin		None
43	Organophosphates	Parathion, CAS-RN: 56-38-2, DTXSID7021100 Soman, CAS-RN: 96-64-0, DTXSID2031906	10 AOPs 405: Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function 450: Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality 490: Co-activation of IP3R and RyR leads to reduced IQ and increased socio-economic burden through non-cholinergic mechanisms 543: Inhibition of neuropathy target esterase leading to delayed neuropathy via lysolecithin cell membrane integration 544: Inhibition of neuropathy target esterase leading to delayed neuropathy via increased inflammation 552: Inhibiton of L-Type Calcium Channels leading to heart failure via QT interval prolongation and Torsades de Pointes (TdP) 555: Inhibition, Ether-a-go-go (ERG) Voltage-Gated Potassium Channel leading to heart failure 556: Decreased Na/K ATPase activity leading to heart failure 560: Inhibition of Funny current (If) leading to Arrhythmias 562: HCN Channel Inhibition leading to Arrhythmias
577	Osilodrostat(LCI699)		349: Inhibition of 11β-hydroxylase leading to decresed population trajectory
453	Other DNA damaging agents		2 AOPs 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer 293: Increased DNA damage leading to increased risk of breast cancer
714	Other heavy metal effects		None
715	Other heavy metals		None
805	Ouabain		556: Decreased Na/K ATPase activity leading to heart failure
829	Oxadiazon	Oxadiazon, CAS-RN: 19666-30-9, DTXSID3024239	561: Aromatase induction leading to estrogen receptor alpha activation via increased estradiol
857	Oxaliplatin	Oxaliplatin, CAS-RN: 61825-94-3, DTXSID0036760	472: DNA adduct formation leading to kidney failure
184	Oxaprozin	Oxaprozin, CAS-RN: 21256-18-8, DTXSID1045118	None
516	oxidative stress		None
744	Oxyclozanide	Oxyclozanide, CAS-RN: 2277-92-1, DTXSID50177312	263: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation
90	Oxytetracycline hydrochloride	Oxytetracycline hydrochloride, CAS-RN: 2058-46-0, DTXSID5021097	None
655	Ozone	Ozone, CAS-RN: 10028-15-6, DTXSID0021098	2 AOPs 411: Oxidative stress Leading to Decreased Lung Function 424: Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction
562	p,p'-DDE	p,p'-DDE, CAS-RN: 72-55-9, DTXSID9020374	561: Aromatase induction leading to estrogen receptor alpha activation via increased estradiol
405	p,p'-DDT	DDT, CAS-RN: 50-29-3, DTXSID4020375	553: Inhibition of Voltage-gated sodium channels (Na⁺ channels) leading to heart failure
410	Paclitaxel	Paclitaxel, CAS-RN: 33069-62-4, DTXSID9023413	None
464	Paclobutrazol	Paclobutrazol, CAS-RN: 76738-62-0, DTXSID2024242	297: Inhibition of retinaldehyde dehydrogenase leads to population decline
649	Paraoxon	Paraoxon, CAS-RN: 311-45-5, DTXSID6024046	2 AOPs 405: Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function 450: Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality
44	Paraquat	Paraquat, CAS-RN: 4685-14-7, DTXSID3034799	6 AOPs 593: Redox cycling of a chemical by mitochondria leads to degeneration of nigrostriatal dopaminergic neurons 324: Reactive oxygen species leading to growth inhibition via oxidative DNA damage and cell cycle disruption 325: Reactive oxygen species leading to growth inhibition via oxidative DNA damage and cell death 326: Reactive oxygen species leading to growth inhibition via lipid peroxidation and decreased cell proliferation 331: Reactive oxygen species leading to growth inhibition via lipid peroxidation and cell death 333: Reactive oxygen species leading to growth inhibition via protein oxidation and cell death
45	Parathion	Parathion, CAS-RN: 56-38-2, DTXSID7021100	559: Inhibition of acetylcholinesterase (AChE) leading to arrhythmias
429	Parthenolide	Parthenolide, CAS-RN: 20554-84-1, DTXSID2040579	None
632	Pathogen Associated Molecular Patterns (PAMPs)		377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
768	PCB 126		2 AOPs 458: AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals 459: AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals