Prototypical Stressors

Showing 126 to 150 of 871 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

549	Atorvastatin	Atorvastatin, CAS-RN: 134523-00-5, DTXSID8029868	None
177	atrazine	Atrazine, CAS-RN: 1912-24-9, DTXSID9020112	5 AOPs 168: GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. 169: GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat. 492: Glutathione conjugation leading to reproductive dysfunction via oxidative stress 561: Aromatase induction leading to estrogen receptor alpha activation via increased estradiol 567: Binding to plastoquinone B site leading to decreased population growth rate via photosystem II inhibition
425	Aurovertin		None
536	Azathioprine	Azathioprine, CAS-RN: 446-86-6, DTXSID4020119	None
266	B2,4,2',		None
625	bacteria		374: Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on brain cells (neuronal and non-neuronal) leads to neuroinflammation resulting in encephalitis
838	Bacterial or viral Infections		524: Gluten-driven immune activation leading to celiac disease in genetically predisposed individuals
573	Beclomethasone dipropionate monohydrate	Beclomethasone dipropionate monohydrate, CAS-RN: 77011-63-3, DTXSID00227831	334: Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration
609	Belnacasan (VX-765)		277: Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response
128	Benomyl	Benomyl, CAS-RN: 17804-35-2, DTXSID5023900	2 AOPs 106: Chemical binding to tubulin in oocytes leading to aneuploid offspring 561: Aromatase induction leading to estrogen receptor alpha activation via increased estradiol
863	Benz(a)anthracene	Benz(a)anthracene, CAS-RN: 56-55-3, DTXSID5023902	3 AOPs 644: Bulky DNA adducts leading to chromosomal aberrations and mutations 645: Binding and activation of AhR lead to cardiovascular aging 646: Binding and activation of AhR/PPARγ lead to lipid metabolism disorders
420	Benzbromarone	Benzbromarone, CAS-RN: 3562-84-3, DTXSID4022652	None
62	Benzidine	C.I. Azoic Diazo Component 112, CAS-RN: 92-87-5, DTXSID2020137	None
538	Benzo(a)pyrene	Benzo(a)pyrene, CAS-RN: 50-32-8, DTXSID2020139	3 AOPs 644: Bulky DNA adducts leading to chromosomal aberrations and mutations 645: Binding and activation of AhR lead to cardiovascular aging 646: Binding and activation of AhR/PPARγ lead to lipid metabolism disorders
859	Benzo(b)fluoranthene	Benzo(b)fluoranthene, CAS-RN: 205-99-2, DTXSID0023907	3 AOPs 644: Bulky DNA adducts leading to chromosomal aberrations and mutations 645: Binding and activation of AhR lead to cardiovascular aging 646: Binding and activation of AhR/PPARγ lead to lipid metabolism disorders
874	Benzo(g,h,i)perylene	Benzo(g,h,i)perylene, CAS-RN: 191-24-2, DTXSID5023908	2 AOPs 645: Binding and activation of AhR lead to cardiovascular aging 646: Binding and activation of AhR/PPARγ lead to lipid metabolism disorders
10	Benzo(k)fluoranthene	Benzo(k)fluoranthene, CAS-RN: 207-08-9, DTXSID0023909	2 AOPs 645: Binding and activation of AhR lead to cardiovascular aging 646: Binding and activation of AhR/PPARγ lead to lipid metabolism disorders
509	benzo[a]pyrene		2 AOPs 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR 563: Aryl hydrocarbon Receptor (AHR) activation causes Premature Ovarian Insufficiency via Bax mediated apoptosis
165	Benzoic acid, 3-methoxy-2-methyl-, 2-(3,5-dimethylbenzoyl)-2-(1,1-dimethylethyl)hydrazide		None
166	Benzoic acid, 4-chloro-, 2-benzoyl-2-(1,1-dimethylethyl)hydrazide		None
427	Beta-carboline		None
543	beta-Sitosterol	beta-Sitosterol, CAS-RN: 83-46-5, DTXSID5022481	None
824	Bethanechol		559: Inhibition of acetylcholinesterase (AChE) leading to arrhythmias
210	Bezafibrate	Bezafibrate, CAS-RN: 41859-67-0, DTXSID3029869	37: PPARα activation leading to hepatocellular adenomas and carcinomas in rodents
580	Bicalutamide	Bicalutamide, CAS-RN: 90357-06-5, DTXSID2022678	None