Prototypical Stressors

Showing 126 to 150 of 853 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

838	Bacterial or viral Infections		524: Gluten-driven immune activation leading to celiac disease in genetically predisposed individuals
573	Beclomethasone dipropionate monohydrate	Beclomethasone dipropionate monohydrate, CAS-RN: 77011-63-3, DTXSID00227831	334: Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration
609	Belnacasan (VX-765)		277: Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response
128	Benomyl	Benomyl, CAS-RN: 17804-35-2, DTXSID5023900	2 AOPs 106: Chemical binding to tubulin in oocytes leading to aneuploid offspring 561: Aromatase induction leading to estrogen receptor alpha activation via increased estradiol
420	Benzbromarone	Benzbromarone, CAS-RN: 3562-84-3, DTXSID4022652	None
62	Benzidine	C.I. Azoic Diazo Component 112, CAS-RN: 92-87-5, DTXSID2020137	None
538	Benzo(a)pyrene	Benzo(a)pyrene, CAS-RN: 50-32-8, DTXSID2020139	None
10	Benzo(k)fluoranthene	Benzo(k)fluoranthene, CAS-RN: 207-08-9, DTXSID0023909	None
509	benzo[a]pyrene		2 AOPs 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR 563: Aryl hydrocarbon Receptor (AHR) activation causes Premature Ovarian Insufficiency via Bax mediated apoptosis
165	Benzoic acid, 3-methoxy-2-methyl-, 2-(3,5-dimethylbenzoyl)-2-(1,1-dimethylethyl)hydrazide		None
166	Benzoic acid, 4-chloro-, 2-benzoyl-2-(1,1-dimethylethyl)hydrazide		None
427	Beta-carboline		None
543	beta-Sitosterol	beta-Sitosterol, CAS-RN: 83-46-5, DTXSID5022481	None
824	Bethanechol		559: Inhibition of acetylcholinesterase (AChE) leading to arrhythmias
210	Bezafibrate	Bezafibrate, CAS-RN: 41859-67-0, DTXSID3029869	37: PPARα activation leading to hepatocellular adenomas and carcinomas in rodents
580	Bicalutamide	Bicalutamide, CAS-RN: 90357-06-5, DTXSID2022678	None
107	Bifenthrin	Bifenthrin, CAS-RN: 82657-04-3, DTXSID9020160	None
474	BIO (6-bromoindirubin-3’-oxime)		410: GSK3beta inactivation leading to increased mortality via defects in developing inner ear
279	Bioflavonoids		202: Inhibitor binding to topoisomerase II leading to infant leukaemia
11	Bis(2-ethylhexyl) phthalate	Di(2-ethylhexyl) phthalate, CAS-RN: 117-81-7, DTXSID5020607	2 AOPs 37: PPARα activation leading to hepatocellular adenomas and carcinomas in rodents 307: Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring
665	Bis(2,4,6-trimethylphenyl)-lambda~2~-germane--selenium (1/1)	Bis(2,4,6-trimethylphenyl)-lambda~2~-germane--selenium (1/1), CAS-RN: 115385-04-1, DTXSID10556604	413: Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure
467	Bisdiamine		2 AOPs 297: Inhibition of retinaldehyde dehydrogenase leads to population decline 436: Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries
521	Bisphenol A	Bisphenol A, CAS-RN: 80-05-7, DTXSID7020182	4 AOPs 314: Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE) 522: Estrogen antagonism leading to increased risk of autism-like behavior 535: Binding and activation of GPER leading to learning and memory impairments 554: β-adrenergic receptor agonists leading to arrhythmias.
775	Bixafen	Bixafen, CAS-RN: 581809-46-3, DTXSID6058134	3 AOPs 534: Succinate dehydrogenase (SDH) inhibition leads to cancer through oxidative stress 474: Succinate dehydrogenase inactivation leads to cancer by promoting EMT 546: Succinate dehydrogenase inactivation leads to cancer through hypoxic-like mechanisms
337	Bleomycin	Bleomycin, CAS-RN: 11056-06-7, DTXSID1030862	2 AOPs 173: Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis 550: Increased LMNA gene mutation leading to heart failure