Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 1026 to 1050 of 1141 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
116 decreased calcium-transporting ATPase activity (GO:0005388) calcium ion-transporting ATPase complex (GO:0090534) 51: Inhibition, Ca++ ATPase
115 decreased Follicle stimulating hormone (CHEBI:81569) 129: Reduction, Gonadotropins, circulating concentrations
114 decreased Luteinizing hormone (CHEBI:81568)
113 decreased oocyte development (GO:0048599) 309: Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development
112 decreased oocyte growth (GO:0001555) 309: Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development
111 decreased receptor-mediated endocytosis (GO:0006898) vitellogenins (MESH:D014819) 309: Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development
110 decreased vitellogenins (MESH:D014819) 221: Reduction, Plasma vitellogenin concentrations
109 decreased egg quantity (VT:1000294)
108 decreased gene expression (GO:0010467) vitellogenins (MESH:D014819) 285: Reduction, Vitellogenin synthesis in liver
107 increased androgen receptor activity (GO:0004882) androgen receptor (PR:000004191) 25: Agonism, Androgen receptor
106 increased gene expression (GO:0010467) prostaglandin G/H synthase 2 (PR:000013428) 1269: Increase, COX-2 expression
105 morphological change abnormal cardiovascular system physiology (MP:0001544) 317: Altered, Cardiovascular development/function
104 morphological change developmental process (GO:0032502) cardiovascular system (UBERON:0004535) None
103 disrupted protein dimerization activity (GO:0046983) aryl hydrocarbon receptor nuclear translocator (PR:000004303) None
102 disrupted protein dimerization activity (GO:0046983) aryl hydrocarbon receptor (PR:000003858) None
101 increased aryl hydrocarbon receptor activity (GO:0004874) aryl hydrocarbon receptor (PR:000003858) 18: Activation, AhR
100 decreased fertility (MESH:D005298)
99 decreased regulation of gene expression (GO:0010468) androgen receptor (PR:000004191) 286: Altered, Transcription of genes by the androgen receptor
98 arrested developmental process (GO:0032502) male reproductive organ (UBERON:0003135) 240: Feminisation or incomplete development, Primary and accessory male sex organs
97 abnormal Wnt signaling pathway (GO:0016055) Wnt signalosome (GO:1990909) 310: Alteration, Wnt pathway
96 decreased androgen receptor activity (GO:0004882) androgen receptor (PR:000004191)
95 morphological change male reproductive organ (UBERON:0003135) 348: Malformation, Male reproductive tract
94 decreased testosterone (CHEBI:17347)
93 decreased testosterone biosynthetic process (GO:0061370) testosterone (CHEBI:17347)
92 decreased mitochondrial transport (GO:0006839) cholesterol (CHEBI:16113) 447: Reduction, Cholesterol transport in mitochondria