AOPs

OECD View API
Toggle for API info
The API endpoint defaults to 25 results per page, but you can adjust this by changing the per_page parameter in the URL.
Searches both title and fulltext content
Takes you to the requested AOP
Clear Search Terms Clears search terms and filters

Showing 226 to 250 of 589 AOPs

Clear Table Filters
ID Title Point of Contact License MIE AO OECD Status OECD Project
424 Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction Karsta Luettich BY-SA 1392: Increase, Oxidative Stress 1250: Decrease, Lung function
423 Toxicological mechanisms of hepatocyte apoptosis through the PARP1 dependent cell death pathway Fei Li BY-SA 1817: Apoptotic cell death
422 Binding of SARS-CoV-2 to ACE2 in enterocytes leads to intestinal barrier disruption Laure-Alix Clerbaux BY-SA 1739: Binding to ACE2 None Under Development 1.96
421 PPARG activation leading to intrahepatic cholestasis Yuan Jin BY-SA None None
420 Aryl hydrocarbon receptor activation leading to lung cancer through sustained NRF2 toxicity pathway Dianke Yu BY-SA 18: Activation, AhR None
419 Aryl hydrocarbon receptor activation leading to impaired lung function through P53 toxicity pathway Dianke Yu BY-SA None 1250: Decrease, Lung function
418 Aryl hydrocarbon receptor activation leading to impaired lung function through AHR-ARNT toxicity pathway Dianke Yu BY-SA None None
417 Aryl hydrocarbon receptor activation leading to lung cancer through AHR-ARNT toxicity pathway Dianke Yu BY-SA 18: Activation, AhR 1670: Lung cancer
416 Aryl hydrocarbon receptor activation leading to lung cancer through IL-6 toxicity pathway Dianke Yu BY-SA 18: Activation, AhR 1670: Lung cancer
415 Aryl hydrocarbon receptor activation leading to lung fibrosis through IL-6 toxicity pathway Dianke Yu BY-SA 18: Activation, AhR 1276: Lung fibrosis
414 Aryl hydrocarbon receptor activation leading to lung fibrosis through TGF-β dependent fibrosis toxicity pathway Dianke Yu BY-SA 18: Activation, AhR None
413 Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure Carmel Mothersill BY-SA 926: Oxidation, Glutathione (To be considered with MIE) 351: Increased Mortality
412 Endothelial cell dysfunction leading to thromboinflammation Luigi Margiotta-Casaluci BY-SA None 1916: Thromboinflammation, Increased Under Development 1.96
411 Oxidative stress Leading to Decreased Lung Function Karsta Luettich BY-SA 1392: Increase, Oxidative Stress 1250: Decrease, Lung function
410 GSK3beta inactivation leading to increased mortality via defects in developing inner ear Vid Modic BY-SA 1647: GSK3beta inactivation
409 Frustrated phagocytosis leads to malignant mesothelioma Penny Nymark BY-SA 1668: Frustrated phagocytosis 1090: Increased, mesotheliomas
408 Imbalance in redox homeostasis leading to structural damage to tissues Fei Li BY-SA None None
407 SARS-CoV-2 infection leading to pyroptosis Hasmik Yepiskoposyan BY-SA 1739: Binding to ACE2 1967: Pyroptosis
406 SARS-CoV-2 infection leading to hyperinflammation Hasmik Yepiskoposyan BY-SA 1739: Binding to ACE2 1868: Hyperinflammation
405 Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function SAROJ AMAR BY-SA 12: Acetylcholinesterase (AchE) Inhibition 402: Cognitive function, decreased
404 Metabolic Syndrome leading to Toll Like Receptor dysregulation Gillina Bezemer BY-SA None None
403 combined unhealthy lifestyle factors leading to metabolic syndrome Gillina Bezemer BY-SA None None
402 Thyroid peroxidase (TPO) inhibition leads to periventricular heterotopia formation in the developing rat brain Katherine (Katie) O'Shaughnessy BY-SA 279: Thyroperoxidase, Inhibition
401 G protein-coupled estrogen receptor 1 (GPER) signal pathway in the lipid metabolism disrupting effects Fei Li BY-SA 2029: protein-coupled estrogen receptor 1 (GPER) activation 1489: Increase, Steatohepatitis
400 Inhibition of CYP26B1 activity in fetal testis leading to reduced fertility Terje Svingen BY-SA 1887: Inhibition of CYP26B1 activity 406: decreased, Fertility