AOPs

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Showing 226 to 250 of 595 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
430 Binding of SARS-CoV-2 to ACE2 leads to viral infection proliferation Sally Mayasich BY-SA 1739: Binding to ACE2 1939: Viral infection and host-to-host transmission, proliferated Under Development 1.96
429 A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants Erwin L Roggen BY-SA None 1941: Memory Loss
428 Binding of S-protein to ACE2 in enterocytes induces ACE2 dysregulation leading to gut dysbiosis Laure-Alix Clerbaux BY-SA 1739: Binding to ACE2 None Under Development 1.96
427 ACE2 downregulation following SARS-CoV-2 infection triggers dysregulation of RAAS and can lead to heart failure. Evangelos-Panagiotis Daskalopoulos BY-SA 1739: Binding to ACE2 1535: Heart failure
426 SARS-CoV-2 spike protein binding to ACE2 receptors expressed on pericytes leads to endothelial cell dysfunction, microvascular injury and myocardial infarction. Evangelos-Panagiotis Daskalopoulos BY-SA 1739: Binding to ACE2 1934: Myocardial Infarction
425 Oxidative Stress Leading to Decreased Lung Function via Decreased FOXJ1 Karsta Luettich BY-SA 1392: Increase, Oxidative Stress 1250: Decrease, Lung function
424 Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction Karsta Luettich BY-SA 1392: Increase, Oxidative Stress 1250: Decrease, Lung function
423 Toxicological mechanisms of hepatocyte apoptosis through the PARP1 dependent cell death pathway Fei Li BY-SA 1817: Apoptotic cell death
422 Binding of SARS-CoV-2 to ACE2 in enterocytes leads to intestinal barrier disruption Laure-Alix Clerbaux BY-SA 1739: Binding to ACE2 None Under Development 1.96
421 PPARG activation leading to intrahepatic cholestasis Yuan Jin BY-SA None None
420 Aryl hydrocarbon receptor activation leading to lung cancer through sustained NRF2 toxicity pathway Dianke Yu BY-SA 18: Activation, AhR None
419 Aryl hydrocarbon receptor activation leading to impaired lung function through P53 toxicity pathway Dianke Yu BY-SA None 1250: Decrease, Lung function
418 Aryl hydrocarbon receptor activation leading to impaired lung function through AHR-ARNT toxicity pathway Dianke Yu BY-SA None None
417 Aryl hydrocarbon receptor activation leading to lung cancer through AHR-ARNT toxicity pathway Dianke Yu BY-SA 18: Activation, AhR 1670: Lung cancer
416 Aryl hydrocarbon receptor activation leading to lung cancer through IL-6 toxicity pathway Dianke Yu BY-SA 18: Activation, AhR 1670: Lung cancer
415 Aryl hydrocarbon receptor activation leading to lung fibrosis through IL-6 toxicity pathway Dianke Yu BY-SA 18: Activation, AhR 1276: Lung fibrosis
414 Aryl hydrocarbon receptor activation leading to lung fibrosis through TGF-β dependent fibrosis toxicity pathway Dianke Yu BY-SA 18: Activation, AhR None
413 Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure Carmel Mothersill BY-SA 926: Oxidation, Glutathione (To be considered with MIE) 351: Increased Mortality
412 Endothelial cell dysfunction leading to thromboinflammation Luigi Margiotta-Casaluci BY-SA None 1916: Thromboinflammation, Increased Under Development 1.96
411 Oxidative stress Leading to Decreased Lung Function Karsta Luettich BY-SA 1392: Increase, Oxidative Stress 1250: Decrease, Lung function
410 GSK3beta inactivation leading to increased mortality via defects in developing inner ear Vid Modic BY-SA 1647: GSK3beta inactivation
409 Frustrated phagocytosis leads to malignant mesothelioma Penny Nymark BY-SA 1668: Frustrated phagocytosis 1090: Increased, mesotheliomas
408 Imbalance in redox homeostasis leading to structural damage to tissues Fei Li BY-SA None None
407 SARS-CoV-2 infection leading to pyroptosis Hasmik Yepiskoposyan BY-SA 1739: Binding to ACE2 1967: Pyroptosis
406 SARS-CoV-2 infection leading to hyperinflammation Hasmik Yepiskoposyan BY-SA 1739: Binding to ACE2 1868: Hyperinflammation