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All Key Events

Showing 1376 to 1400 of 1907 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1868	Hyperinflammation Short Name Hyperinflammation	10	Tissue	Apr 20, 2021	Dec 29, 2021	4 AOPs 392: Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation 406: SARS-CoV-2 infection leading to hyperinflammation 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) 468: Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death)
1869	Diminished protective oxidative stress response Short Name Diminished Protective Response to ROS	3	Cellular	Apr 20, 2021	Oct 30, 2023	5 AOPs 379: Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation 406: SARS-CoV-2 infection leading to hyperinflammation 407: SARS-CoV-2 infection leading to pyroptosis 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) 488: Increased reactive oxygen species production leading to decreased cognitive function
1870	Sustentacular cells, decrease Short Name Sustentacular cells, decrease	0	Cellular	Apr 25, 2021	Mar 30, 2022	394: SARS-CoV-2 infection of olfactory epithelium leading to impaired olfactory function (short-term anosmia)
1871	olfactory sensory neurons, decrease Short Name olfacotry neurons, decrease	0	Cellular	Apr 25, 2021	Mar 30, 2022	394: SARS-CoV-2 infection of olfactory epithelium leading to impaired olfactory function (short-term anosmia)
1872	Olfactory epithelium degeneration Short Name Olfactory epithelium degeneration	0	Tissue	Apr 25, 2021	Mar 30, 2022	394: SARS-CoV-2 infection of olfactory epithelium leading to impaired olfactory function (short-term anosmia)
1873	impaired olfactory function (anosmia) Short Name anosmia	0	Organ	Apr 25, 2021	Mar 30, 2022	394: SARS-CoV-2 infection of olfactory epithelium leading to impaired olfactory function (short-term anosmia)
1874	blood brain barrier disruption Short Name BBB disruption	0	Cellular	Apr 27, 2021	Apr 27, 2021	395: Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on pericytes leads to disseminated intravascular coagulation resulting in cerebrovascular disease (stroke)
1875	Cerebrovascular disease (stroke) Short Name stroke	0	Organ	Apr 27, 2021	Mar 30, 2022	395: Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on pericytes leads to disseminated intravascular coagulation resulting in cerebrovascular disease (stroke)
1876	ACE2 shedding effects on viral entry Short Name Hyunjoon Kong	0	Cellular	Apr 28, 2021	Apr 28, 2021	None
1877	Altered, retinal layer structure Short Name Altered, retinal layer structure	1	Tissue	May 11, 2021	Jul 8, 2022	363: Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure
1878	Decreased, Eye size Short Name Decreased, Eye size	1	Organ	May 11, 2021	Jun 24, 2021	2 AOPs 364: Thyroperoxidase inhibition leading to altered visual function via decreased eye size 399: Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos)
1879	Bulky DNA adducts, increase Short Name Bulky DNA adducts, increase	1	Molecular	May 17, 2021	May 17, 2021	397: Bulky DNA adducts leading to mutations
1880	Decreased, ALDH1A (RALDH) enzyme activity Short Name Decreased, ALDH1A activity	1	Molecular	May 24, 2021	Dec 17, 2024	2 AOPs 398: Decreased ALDH1A (RALDH) activity leading to decreased fertility via disrupted meiotic initiation of fetal oogonia 436: Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries
1881	Decreased, all-trans retinoic acid (atRA) concentration Short Name Decreased, atRA concentration	1	Tissue	May 24, 2021	Feb 13, 2023	2 AOPs 398: Decreased ALDH1A (RALDH) activity leading to decreased fertility via disrupted meiotic initiation of fetal oogonia 436: Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries
1882	Disrupted, initiation of meiosis of oogonia in the ovary Short Name Disrupted, meiotic initiation in oocyte	1	Cellular	May 24, 2021	Jul 4, 2025	398: Decreased ALDH1A (RALDH) activity leading to decreased fertility via disrupted meiotic initiation of fetal oogonia
1883	Decreased, size of the ovarian reserve Short Name Decreased, ovarian reserve	1	Organ	May 24, 2021	Jul 27, 2025	2 AOPs 398: Decreased ALDH1A (RALDH) activity leading to decreased fertility via disrupted meiotic initiation of fetal oogonia 563: Aryl hydrocarbon Receptor (AHR) activation causes Premature Ovarian Insufficiency via Bax mediated apoptosis
1884	Inhibition of Fyna Short Name Inhibition of Fyna	1	Molecular	May 28, 2021	Dec 12, 2021	399: Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos)
1885	Inhibition of Plxna2 Short Name Inhibition of Plxna2	0	Molecular	May 28, 2021	Oct 7, 2021	399: Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos)
1886	Overexpression of rasl11b Short Name Overexpression of rasl11b	0	Molecular	May 28, 2021	Dec 8, 2021	399: Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos)
1887	Inhibition of CYP26B1 activity Short Name CYP26B1, inhibition	0	Molecular	May 28, 2021	Nov 11, 2021	400: Inhibition of CYP26B1 activity in fetal testis leading to reduced fertility
1888	Increased (ectopic) all-trans retinoic acid concentration Short Name increased atRA concentration	0	Tissue	May 29, 2021	Nov 11, 2021	400: Inhibition of CYP26B1 activity in fetal testis leading to reduced fertility
1889	Premature initiation of meiosis in fetal male germ cells Short Name premature meiosis, male germ cells	0	Cellular	May 29, 2021	Nov 11, 2021	400: Inhibition of CYP26B1 activity in fetal testis leading to reduced fertility
1890	Decrease (loss of) fetal male germ cells Short Name Germ cell loss, male	0	Cellular	May 29, 2021	Nov 11, 2021	400: Inhibition of CYP26B1 activity in fetal testis leading to reduced fertility
1891	abnormal, placental vasculature morphology Short Name	0	Tissue	May 31, 2021	Jun 26, 2025	151: AhR activation leading to preeclampsia
1892	increase, placental insufficiency Short Name increase, placental insufficiency	0	Organ	May 31, 2021	May 31, 2021	151: AhR activation leading to preeclampsia