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All Key Events

Showing 1626 to 1650 of 1907 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

2124	increased, Bax expression Short Name increased, Bax	1	Molecular	Apr 4, 2023	May 20, 2025	2 AOPs 490: Co-activation of IP3R and RyR leads to reduced IQ and increased socio-economic burden through non-cholinergic mechanisms 563: Aryl hydrocarbon Receptor (AHR) activation causes Premature Ovarian Insufficiency via Bax mediated apoptosis
2125	Increased fat mass Short Name Increased fat mass	0	Organ	Apr 5, 2023	Apr 5, 2023	493: ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity
2126	Estrogen receptor alpha inactivation Short Name ERa inactivation	0	Molecular	Apr 5, 2023	Apr 10, 2023	2 AOPs 493: ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity 497: ERa inactivation alters mitochondrial functions and insulin signalling in skeletal muscle and leads to insulin resistance and metabolic syndrome
2127	Increased adipocyte size Short Name Increased adipocyte size	0	Cellular	Apr 5, 2023	Apr 5, 2023	493: ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity
2128	Increased adipocyte numbers Short Name Increased adipocyte numbers	0	Cellular	Apr 5, 2023	Apr 5, 2023	493: ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity
2129	Metabolically unhealthy Obesity Short Name Metabolically unhealthy Obesity	0	Individual	Apr 5, 2023	Apr 5, 2023	493: ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity
2130	increased lipid accumulation Short Name increased lipid accumulation	0	Cellular	Apr 5, 2023	Apr 5, 2023	493: ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity
2131	Conjugation, GSH Short Name Conjugation, GSH	1	Cellular	Apr 5, 2023	Sep 14, 2023	492: Glutathione conjugation leading to reproductive dysfunction via oxidative stress
2132	Increased pro-inflammatory cytokine expression Short Name Increased cytokine expression	0	Cellular	Apr 6, 2023	Apr 6, 2023	493: ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity
2133	Increase, Glucuronidation of T4 Short Name Increase, Glucuronidation of T4	0	Molecular	Apr 12, 2023	Apr 12, 2023	None
2134	Increase, Androgen receptor protein expression/abundance Short Name	0	Cellular	May 11, 2023	Dec 31, 2024	495: Androgen receptor activation leading to prostate cancer
2135	Prostate cancer Short Name Prostate cancer	0	Individual	May 11, 2023	May 11, 2023	495: Androgen receptor activation leading to prostate cancer
2136	prostatic intraepithelial neoplasia Short Name prostatic intraepithelial neoplasia	0	Tissue	May 11, 2023	May 11, 2023	495: Androgen receptor activation leading to prostate cancer
2137	Increase, Gonadotropins concentration in plasma Short Name	1	Cellular	May 16, 2023	Jan 29, 2026	2 AOPs 496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish） 623: Activation, estrogen receptor alpha leads to persistent vaginal cornification via increased kisspeptin release
2139	Reduction, the ratio of 17beta-estradiol/11-Keto Testosterone in plasma Short Name	0	Organ	May 16, 2023	May 16, 2023	496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish）
2140	Decreased spawning and cumulative fecundity, decreased gonadosomatic index Short Name	0	Individual	May 16, 2023	May 16, 2023	None
2141	Disruption, Estrogen receptor Short Name Disruption of ER	0	Molecular	May 17, 2023	May 17, 2023	476: Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity
2142	Depletion, Ectoplasmic specialization (ES) Short Name Depletion of ES	0	Cellular	May 17, 2023	May 17, 2023	476: Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity
2144	Impaired insulin signaling Short Name Impaired insulin signaling	0	Cellular	May 25, 2023	May 25, 2023	497: ERa inactivation alters mitochondrial functions and insulin signalling in skeletal muscle and leads to insulin resistance and metabolic syndrome
2145	Metabolic syndrome Short Name Metabolic syndrome	0	Population	May 25, 2023	May 25, 2023	497: ERa inactivation alters mitochondrial functions and insulin signalling in skeletal muscle and leads to insulin resistance and metabolic syndrome
2146	Activation of mitogen-activated protein kinase kinase, extracellular signal-regulated kinase 1/2 Short Name Activation of MEK, ERK1/2	1	Molecular	May 25, 2023	Jul 28, 2023	2 AOPs 499: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via disrupted neurotransmitter release 500: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis
2147	Decreased, Viable Offspring Short Name Decreased, Viable Offspring	2	Individual	Jun 2, 2023	Apr 10, 2024	2 AOPs 323: PPARalpha Agonism Leading to Decreased Viable Offspring via Decreased 11-Ketotestosterone 521: Essential element imbalance leads to reproductive failure via oxidative stress
2148	Increased LCN2/iron complex binds to SLC22A17 receptor in neuron Short Name Increased LCN2/iron complex	0	Molecular	Jun 15, 2023	Jun 15, 2023	498: Increased LCN2/iron complex leading to neurological disorders
2149	Increased intracelluar Iron accumulation Short Name Increased intracelluar Iron	0	Cellular	Jun 15, 2023	Jun 15, 2023	2 AOPs 498: Increased LCN2/iron complex leading to neurological disorders 501: Excessive iron accumulation leading to neurological disorders
2150	Neurological disorder Short Name Neurological disorder	0	Individual	Jun 15, 2023	Jun 15, 2023	3 AOPs 498: Increased LCN2/iron complex leading to neurological disorders 501: Excessive iron accumulation leading to neurological disorders 471: Neuron defect induced early behavioral change