AOP-Wiki

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All Key Events

Showing 351 to 375 of 1939 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

2089	Altered Bone Cell Homeostasis Short Name Altered Bone Cell Homeostasis	2	Cellular	Jan 11, 2023	Aug 23, 2024	2 AOPs 482: Deposition of energy leading to occurrence of bone loss 334: Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration
2088	Dysfunction of respiratory system Short Name Respiratory dysfunction	0	Individual	Jan 9, 2023	Jan 9, 2023	481: AOPs of amorphous silica nanoparticles: ROS-mediated oxidative stress increased respiratory dysfunction and diseases.
2087	Increased incidence of respiratory disease Short Name	0	Individual	Jan 9, 2023	Jan 9, 2023	481: AOPs of amorphous silica nanoparticles: ROS-mediated oxidative stress increased respiratory dysfunction and diseases.
2086	Airway inflammation Short Name Airway inflammation	0	Organ	Jan 9, 2023	Jan 17, 2023	481: AOPs of amorphous silica nanoparticles: ROS-mediated oxidative stress increased respiratory dysfunction and diseases.
2085	Pulmonary epithelial injury Short Name Pulmonary epithelial injury	0	Cellular	Jan 9, 2023	Jul 11, 2023	481: AOPs of amorphous silica nanoparticles: ROS-mediated oxidative stress increased respiratory dysfunction and diseases.
2084	Increase, Cardiac remodelling Short Name Increase, Cardiac remodelling	0	Tissue	Jan 5, 2023	Jan 5, 2023	479: Mitochondrial complexes inhibition leading to left ventricular function decrease via increased myocardial oxidative stress
2083	Occurrence of Cataracts Short Name Cataracts	1	Organ	Dec 18, 2022	Dec 17, 2024	478: Deposition of energy leading to occurrence of cataracts
2082	Hypospadias, increased Short Name Hypospadias	1	Organ	Dec 18, 2022	Mar 20, 2026	4 AOPs 477: Androgen receptor (AR) antagonism leading to hypospadias in male (mammalian) offspring 527: Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Hypospadias, increased 570: Decreased testosterone synthesis leading to hypospadias in male (mammalian) offspring 571: 5α-reductase inhibition leading to hypospadias in male (mammalian) offspring
2081	Increased Modified Proteins Short Name Modified Proteins	1	Molecular	Dec 16, 2022	Mar 8, 2024	478: Deposition of energy leading to occurrence of cataracts
2080	Impaired, blood testis barrier Short Name Impaired, blood testis barrier	0	Organ	Dec 13, 2022	Dec 13, 2022	2 AOPs 476: Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity 595: Emerging OPFRS reproductive outcome pathway
2079	Increased, glycolipid levels Short Name Increased glycolipid levels	0	Cellular	Dec 13, 2022	May 17, 2023	476: Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity
2078	Loss of drebrin Short Name Loss of drebrin	3	Cellular	Dec 11, 2022	Apr 3, 2025	2 AOPs 475: Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons 471: Neuron defect induced early behavioral change
2077	Increase, pulmonate breathing Short Name	0	Individual	Nov 16, 2022	Nov 16, 2022	473: Energy deposition from internalized Ra-226 decay lower oxygen binding capacity of hemocyanin
2076	Increase, hemocyanin mRNA Short Name Increase, hemocyanin mRNA	0	Tissue	Nov 16, 2022	Nov 16, 2022	473: Energy deposition from internalized Ra-226 decay lower oxygen binding capacity of hemocyanin
2075	Cognitive, sensed as hypoxic/low oxygen environment Short Name Hemocyanin Bohr effect decrease	0	Organ	Nov 16, 2022	Nov 16, 2022	473: Energy deposition from internalized Ra-226 decay lower oxygen binding capacity of hemocyanin
2074	Decreased, oxygen binding capacity by hemocyanin Short Name	0	Molecular	Nov 16, 2022	Nov 16, 2022	473: Energy deposition from internalized Ra-226 decay lower oxygen binding capacity of hemocyanin
2073	increase oxidation of the di-copper moiety of the hemocyanin active site Short Name	0	Molecular	Nov 16, 2022	Nov 16, 2022	473: Energy deposition from internalized Ra-226 decay lower oxygen binding capacity of hemocyanin
2072	Increase, Mitochondrial swelling Short Name Increase, Mitochondrial swelling	0	Cellular	Nov 1, 2022	Nov 1, 2022	268: Uncoupling of oxidative phosphorylation leading to growth inhibition via mitochondrial swelling
2071	Decrease, Glucose pool Short Name Decrease, Glucose pool	0	Cellular	Nov 1, 2022	Nov 1, 2022	267: Uncoupling of oxidative phosphorylation leading to growth inhibition via glucose depletion
2070	Increase, Glycolysis Short Name Increase, Glycolysis	0	Cellular	Nov 1, 2022	Nov 1, 2022	267: Uncoupling of oxidative phosphorylation leading to growth inhibition via glucose depletion
2069	Occurrence, Abnormal Vascular Remodeling Short Name	1	Organ	Oct 17, 2022	Sep 17, 2024	470: Deposition of energy leads to abnormal vascular remodeling
2068	Increase, Endothelial Dysfunction Short Name Increase, Endothelial Dysfunction	1	Tissue	Sep 28, 2022	Aug 26, 2024	2 AOPs 470: Deposition of energy leads to abnormal vascular remodeling 462: Activation of reactive oxygen species leading the atherosclerosis
2067	Altered, Nitric Oxide Levels Short Name Altered, Nitric Oxide Levels	1	Cellular	Sep 28, 2022	Apr 13, 2023	470: Deposition of energy leads to abnormal vascular remodeling
2066	Altered Signaling Pathways Short Name Altered Signaling	0	Molecular	Sep 28, 2022	Feb 13, 2024	550: Increased LMNA gene mutation leading to heart failure
2065	Inhibition, Fatty acid oxidation Short Name Inhibition, Fatty acid oxidation	0	Cellular	Sep 19, 2022	Sep 28, 2022	454: PM2.5-related AOP frameworks on liver diseases