AOP-Wiki

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All Key Events

Showing 501 to 525 of 1939 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1933	Increased, Interleukin-6 production Short Name Increased IL-6 production	0	Cellular	Sep 20, 2021	Sep 20, 2021	416: Aryl hydrocarbon receptor activation leading to lung cancer through IL-6 toxicity pathway
1932	Gastrointestinal disorders Short Name GI disorders	0	Individual	Sep 2, 2021	Sep 8, 2021	None
1931	Intestinal barrier, disruption Short Name Disruption of the intestinal barrier	1	Organ	Sep 1, 2021	Apr 27, 2025	4 AOPs 422: Binding of SARS-CoV-2 to ACE2 in enterocytes leads to intestinal barrier disruption 530: Endocytotic lysosomal uptake leads to intestinal barrier disruption 524: Gluten-driven immune activation leading to celiac disease in genetically predisposed individuals 642: Intestinal FXR inhibition leading to steatohepatitis via gut‑liver axis dysregulation
1930	altered, inner ear development Short Name Altered, inner ear development	1	Organ	Aug 23, 2021	Aug 24, 2021	410: GSK3beta inactivation leading to increased mortality via defects in developing inner ear
1929	Increased incidence of cardiovascular morbidity and mortality in the general population Short Name	0	Population	Aug 21, 2021	Aug 21, 2021	519: Cardiac ion channels blockade leading to increased incidence of cardiovascular morbidity and mortality
1928	increased，Vascular endothelial dysfunction Short Name	0	Tissue	Aug 19, 2021	Sep 1, 2021	6 AOPs 507: Nrf2 inhibition leading to vascular disrupting effects via inflammation pathway 508: Nrf2 inhibition leading to vascular disrupting effects through activating HIF1α, Semaphorin 6A, and Dll4-Notch pathway 509: Nrf2 inhibition leading to vascular disrupting effects through activating apoptosis signal pathway and mitochondrial dysfunction 510: Demethylation of PPAR promotor leading to vascular disrupting effects 511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects 538: Adverse outcome pathway of PFAS-induced vascular disrupting effects via activating oxidative stress related pathways
1927	Increased，Vascular endothelial cell autophagy dysfunction Short Name	0	Cellular	Aug 19, 2021	Sep 1, 2021	None
1926	Increased，Vascular fibrosis Short Name Increased，Vascular fibrosis	0	Tissue	Aug 19, 2021	Sep 1, 2021	None
1925	Increased，Vascular smooth muscle cell activation Short Name	0	Cellular	Aug 19, 2021	Sep 1, 2021	None
1924	Increased，Cardiac fibrosis Short Name Increased，Cardiac fibrosis	0	Organ	Aug 19, 2021	Sep 1, 2021	550: Increased LMNA gene mutation leading to heart failure
1923	Altered gene expression, P53 dependent apoptosis pathway Short Name	0	Molecular	Aug 19, 2021	Aug 19, 2021	419: Aryl hydrocarbon receptor activation leading to impaired lung function through P53 toxicity pathway
1922	Increased, Reactive metabolites production Short Name Increased, metabolites	0	Cellular	Aug 19, 2021	Aug 26, 2021	417: Aryl hydrocarbon receptor activation leading to lung cancer through AHR-ARNT toxicity pathway
1921	Altered gene expression, NF-kB dependent Interleukin-6 pathway Short Name	0	Molecular	Aug 19, 2021	Aug 19, 2021	2 AOPs 415: Aryl hydrocarbon receptor activation leading to lung fibrosis through IL-6 toxicity pathway 416: Aryl hydrocarbon receptor activation leading to lung cancer through IL-6 toxicity pathway
1920	Altered gene expression, TGF-β dependent fibrosis pathway Short Name	0	Molecular	Aug 19, 2021	Aug 19, 2021	414: Aryl hydrocarbon receptor activation leading to lung fibrosis through TGF-β dependent fibrosis toxicity pathway
1919	Increased，Cardiac Dysregulation Short Name Increased，Cardiac dysfunction	0	Tissue	Aug 18, 2021	Sep 1, 2021	None
1918	Increased，Myocardial apoptosis Short Name Increased，Myocardial apoptosis	0	Cellular	Aug 18, 2021	Sep 1, 2021	None
1917	Altered gene expression, NRF2 dependent antioxidant pathway Short Name	0	Molecular	Aug 17, 2021	Aug 19, 2021	3 AOPs 421: PPARG activation leading to intrahepatic cholestasis 420: Aryl hydrocarbon receptor activation leading to lung cancer through sustained NRF2 toxicity pathway 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
1916	Thromboinflammation, Increased Short Name Thromboinflammation, Increased	0	Organ	Aug 4, 2021	Aug 4, 2021	412: Endothelial cell dysfunction leading to thromboinflammation
1915	Neutrophil activation, Increased Short Name Neutrophil activation, Increased	0	Cellular	Aug 4, 2021	Aug 4, 2021	412: Endothelial cell dysfunction leading to thromboinflammation
1914	Platelet activation, Increased Short Name Platelet activation, Increased	0	Cellular	Aug 4, 2021	Aug 4, 2021	412: Endothelial cell dysfunction leading to thromboinflammation
1913	Endothelial cell dysfunction Short Name Endothelial cell dysfunction	0	Cellular	Aug 4, 2021	Aug 4, 2021	2 AOPs 412: Endothelial cell dysfunction leading to thromboinflammation 426: SARS-CoV-2 spike protein binding to ACE2 receptors expressed on pericytes leads to endothelial cell dysfunction, microvascular injury and myocardial infarction.
1912	Motile Cilia Number/Length, Decreased Short Name Motile Cilia Number/Length, Decreased	1	Cellular	Jul 23, 2021	Sep 10, 2021	425: Oxidative Stress Leading to Decreased Lung Function via Decreased FOXJ1
1911	FOXJ1 Protein, Decreased Short Name FOXJ1 Protein, Decreased	1	Cellular	Jul 23, 2021	Sep 10, 2021	425: Oxidative Stress Leading to Decreased Lung Function via Decreased FOXJ1
1910	Mucus Viscosity, Increased Short Name Mucus Viscosity, Increased	1	Organ	Jul 19, 2021	Sep 9, 2021	None
1909	Mucociliary Clearance, Decreased Short Name MCC, Decreased	1	Individual	Jul 19, 2021	Sep 10, 2021	3 AOPs 411: Oxidative stress Leading to Decreased Lung Function 424: Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction 425: Oxidative Stress Leading to Decreased Lung Function via Decreased FOXJ1