AOP-Wiki

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All Key Events

Showing 1526 to 1550 of 1907 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

2024	Reduced complex sphingolipids Short Name Reduced complex sphingolipids	0	Cellular	Jul 14, 2022	Jul 19, 2022	449: Ceramide synthase inhibition leading to neural tube defects
2025	Affected folate transporter Short Name Affected folate transporter	0	Cellular	Jul 14, 2022	Jul 14, 2022	449: Ceramide synthase inhibition leading to neural tube defects
2026	decreased folate uptake Short Name decrease folate	0	Cellular	Jul 14, 2022	Jul 14, 2022	449: Ceramide synthase inhibition leading to neural tube defects
2027	Antagonism, Smoothened receptor Short Name Antagonism Smoothened	1	Molecular	Jul 15, 2022	Mar 25, 2025	460: Antagonism of Smoothened receptor leading to orofacial clefting
2028	Decrease, GLI1/2 translocation to nucleus Short Name Decrease, GLI1/2 translocation	2	Molecular	Jul 15, 2022	Oct 28, 2022	2 AOPs 460: Antagonism of Smoothened receptor leading to orofacial clefting 502: Decrease, cholesterol synthesis leads to orofacial clefting
2029	protein-coupled estrogen receptor 1 (GPER) activation Short Name GPER activation	0	Molecular	Jul 18, 2022	Jul 18, 2022	2 AOPs 401: G protein-coupled estrogen receptor 1 (GPER) signal pathway in the lipid metabolism disrupting effects 535: Binding and activation of GPER leading to learning and memory impairments
2030	Activation, PARP1 Short Name PARP1	0	Molecular	Jul 18, 2022	Jul 18, 2022	423: Toxicological mechanisms of hepatocyte apoptosis through the PARP1 dependent cell death pathway
2031	Releasing, Apoptosis-Inducing Factor (AIF) Short Name AIF release	0	Molecular	Jul 18, 2022	Jul 18, 2022	423: Toxicological mechanisms of hepatocyte apoptosis through the PARP1 dependent cell death pathway
2032	Viable offspring, decreased Short Name Viable offspring, decreased	0	Individual	Jul 18, 2022	Jul 18, 2022	None
2033	Increased sphingolipid-1-phosphate Short Name Increased S1-P	0	Cellular	Jul 19, 2022	Jul 19, 2022	449: Ceramide synthase inhibition leading to neural tube defects
2034	liver dysfunction Short Name liver dysfunction	0	Organ	Jul 20, 2022	Jul 20, 2022	463: The AOP framwork on silica nanopariticles induced hepatoxicity
2035	development, liver cancer Short Name development, liver cancer	0	Tissue	Jul 21, 2022	Jul 21, 2022	None
2036	Activation of metabotropic glutamate receptor Short Name Activation, mGLUr	0	Molecular	Jul 25, 2022	Jul 25, 2022	464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
2037	Inositol triphosphate receptor activation Short Name Activation, IP3R	0	Molecular	Jul 25, 2022	May 29, 2025	2 AOPs 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits 490: Co-activation of IP3R and RyR leads to reduced IQ and increased socio-economic burden through non-cholinergic mechanisms
2038	Activation of calpain signalling Short Name Activation, calpain	0	Cellular	Jul 25, 2022	Jul 25, 2022	464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
2039	Inhibition GABAA receptor Short Name Inhibition, GABAAr	0	Molecular	Jul 25, 2022	Jul 25, 2022	464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
2040	Decrease, GLI1/2 target gene expression Short Name Decrease, GLI1/2 target gene expression	2	Cellular	Jul 25, 2022	Apr 2, 2025	3 AOPs 460: Antagonism of Smoothened receptor leading to orofacial clefting 491: Decrease, GLI1/2 target gene expression leads to orofacial clefting 502: Decrease, cholesterol synthesis leads to orofacial clefting
2041	Decrease, facial prominence outgrowth Short Name Decrease, facial prominence outgrowth	2	Tissue	Jul 27, 2022	Apr 3, 2025	3 AOPs 460: Antagonism of Smoothened receptor leading to orofacial clefting 491: Decrease, GLI1/2 target gene expression leads to orofacial clefting 502: Decrease, cholesterol synthesis leads to orofacial clefting
2042	Increase, Orofacial clefting Short Name orofacial cleft	2	Individual	Jul 27, 2022	Apr 3, 2025	3 AOPs 460: Antagonism of Smoothened receptor leading to orofacial clefting 491: Decrease, GLI1/2 target gene expression leads to orofacial clefting 502: Decrease, cholesterol synthesis leads to orofacial clefting
2043	Decrease, Sonic Hedgehog second messenger production Short Name	1	Cellular	Aug 12, 2022	Mar 22, 2023	3 AOPs 460: Antagonism of Smoothened receptor leading to orofacial clefting 491: Decrease, GLI1/2 target gene expression leads to orofacial clefting 502: Decrease, cholesterol synthesis leads to orofacial clefting
2044	Decrease, Smoothend relocation and activation Short Name Decrease, SMO relocation	1	Cellular	Aug 23, 2022	Oct 27, 2022	460: Antagonism of Smoothened receptor leading to orofacial clefting
2045	Increase, Alcohol dehydrogenase Short Name Increase, Alcohol dehydrogenase	0	Molecular	Aug 28, 2022	Aug 28, 2022	465: Alcohol dehydrogenase leading to reproductive dysfunction
2046	Increase, Vitellogenin mRNA Short Name Increase, Vitellogenin mRNA	0	Molecular	Aug 28, 2022	Aug 28, 2022	465: Alcohol dehydrogenase leading to reproductive dysfunction
2047	Delay, Ovarian maturation Short Name Delay, Ovarian maturation	0	Cellular	Aug 28, 2022	Aug 28, 2022	465: Alcohol dehydrogenase leading to reproductive dysfunction
2048	Increase, Body volume of female adults Short Name Increase, Body volume of female adults	0	Individual	Aug 28, 2022	Aug 28, 2022	465: Alcohol dehydrogenase leading to reproductive dysfunction