AOP-Wiki

API

All Key Events

Showing 1576 to 1600 of 1907 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

2074	Decreased, oxygen binding capacity by hemocyanin Short Name	0	Molecular	Nov 16, 2022	Nov 16, 2022	473: Energy deposition from internalized Ra-226 decay lower oxygen binding capacity of hemocyanin
2075	Cognitive, sensed as hypoxic/low oxygen environment Short Name Hemocyanin Bohr effect decrease	0	Organ	Nov 16, 2022	Nov 16, 2022	473: Energy deposition from internalized Ra-226 decay lower oxygen binding capacity of hemocyanin
2076	Increase, hemocyanin mRNA Short Name Increase, hemocyanin mRNA	0	Tissue	Nov 16, 2022	Nov 16, 2022	473: Energy deposition from internalized Ra-226 decay lower oxygen binding capacity of hemocyanin
2077	Increase, pulmonate breathing Short Name	0	Individual	Nov 16, 2022	Nov 16, 2022	473: Energy deposition from internalized Ra-226 decay lower oxygen binding capacity of hemocyanin
2078	Loss of drebrin Short Name Loss of drebrin	3	Cellular	Dec 11, 2022	Apr 3, 2025	2 AOPs 475: Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons 471: Neuron defect induced early behavioral change
2079	Increased, glycolipid levels Short Name Increased glycolipid levels	0	Cellular	Dec 13, 2022	May 17, 2023	476: Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity
2080	Impaired, blood testis barrier Short Name Impaired, blood testis barrier	0	Organ	Dec 13, 2022	Dec 13, 2022	2 AOPs 476: Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity 595: Emerging OPFRS reproductive outcome pathway
2081	Increased Modified Proteins Short Name Modified Proteins	1	Molecular	Dec 16, 2022	Mar 8, 2024	478: Deposition of energy leading to occurrence of cataracts
2082	Hypospadias, increased Short Name Hypospadias	1	Organ	Dec 18, 2022	Sep 18, 2025	4 AOPs 477: Androgen receptor (AR) antagonism leading to hypospadias in male (mammalian) offspring 527: Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Hypospadias, increased 570: Decreased testosterone synthesis leading to hypospadias in male (mammalian) offspring 571: 5α-reductase inhibition leading to hypospadias in male (mammalian) offspring
2083	Occurrence of Cataracts Short Name Cataracts	1	Organ	Dec 18, 2022	Dec 17, 2024	478: Deposition of energy leading to occurrence of cataracts
2084	Increase, Cardiac remodelling Short Name Increase, Cardiac remodelling	0	Tissue	Jan 5, 2023	Jan 5, 2023	479: Mitochondrial complexes inhibition leading to left ventricular function decrease via increased myocardial oxidative stress
2085	Pulmonary epithelial injury Short Name Pulmonary epithelial injury	0	Cellular	Jan 9, 2023	Jul 11, 2023	481: AOPs of amorphous silica nanoparticles: ROS-mediated oxidative stress increased respiratory dysfunction and diseases.
2086	Airway inflammation Short Name Airway inflammation	0	Organ	Jan 9, 2023	Jan 17, 2023	481: AOPs of amorphous silica nanoparticles: ROS-mediated oxidative stress increased respiratory dysfunction and diseases.
2087	Increased incidence of respiratory disease Short Name	0	Individual	Jan 9, 2023	Jan 9, 2023	481: AOPs of amorphous silica nanoparticles: ROS-mediated oxidative stress increased respiratory dysfunction and diseases.
2088	Dysfunction of respiratory system Short Name Respiratory dysfunction	0	Individual	Jan 9, 2023	Jan 9, 2023	481: AOPs of amorphous silica nanoparticles: ROS-mediated oxidative stress increased respiratory dysfunction and diseases.
2089	Altered Bone Cell Homeostasis Short Name Altered Bone Cell Homeostasis	2	Cellular	Jan 11, 2023	Aug 23, 2024	2 AOPs 482: Deposition of energy leading to occurrence of bone loss 334: Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration
2090	Increase, Bone Remodeling Short Name Bone Remodeling	3	Tissue	Jan 11, 2023	Aug 13, 2024	482: Deposition of energy leading to occurrence of bone loss
2091	Occurrence, Bone Loss Short Name Bone Loss	2	Organ	Jan 11, 2023	Aug 23, 2024	482: Deposition of energy leading to occurrence of bone loss
2092	Promotion, Ovarian Cancer Short Name Promotion, Ovarian Cancer	1	Organ	Jan 12, 2023	Mar 11, 2023	440: Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia
2093	Brain thyroid hormone (T4/T3) decreased Short Name Decreased brain T4/T3	0	Organ	Jan 19, 2023	Jan 19, 2023	2 AOPs 402: Thyroid peroxidase (TPO) inhibition leads to periventricular heterotopia formation in the developing rat brain 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
2094	Abnormal, neuroblast migration Short Name Abnormal cell migration in brain	0	Cellular	Jan 19, 2023	Jan 19, 2023	402: Thyroid peroxidase (TPO) inhibition leads to periventricular heterotopia formation in the developing rat brain
2095	Periventricular heterotopia formation Short Name Heterotopia formation	0	Individual	Jan 19, 2023	Jan 19, 2023	402: Thyroid peroxidase (TPO) inhibition leads to periventricular heterotopia formation in the developing rat brain
2096	Occurrence, (Micro)vascular dysfunction Short Name (Micro)vascular dysfunction	4	Tissue	Jan 23, 2023	Jul 31, 2023	385: Viral spike protein interaction with ACE2 leads to microvascular dysfunction, via ACE2 dysregulation
2097	Increase, Pro-Inflammatory Mediators Short Name Increase, Pro-Inflammatory Mediators	1	Tissue	Jan 25, 2023	Jul 26, 2024	483: Deposition of Energy Leading to Learning and Memory Impairment
2098	Increase, Abnormal Neural Remodeling Short Name Abnormal Neural Remodeling	3	Tissue	Jan 25, 2023	Jul 26, 2024	483: Deposition of Energy Leading to Learning and Memory Impairment