Key Event Relationships (KERs)

API

Fulltext search has been disabled for Key Event Relationships (KERs) at this time. If you need this feature, send an email to aopwiki@googlegroups.com

Queries Key Event Relationship (KER) titles
Filter by Upstream Key Event title
Filter by Downstream Key Event title
Filter by AOP title
Clear All Filters

Showing 501 to 525 of 3164 KERs

Clear Table Filters
ID Upstream Event Downstream Event Creation Date Last Updated AOPs
3693 1262: Apoptosis 2391: Reduced fertility Nov 7, 2025 Nov 7, 2025
3759 1262: Apoptosis 344: Increase, Liver fibrosis Mar 25, 2026 Mar 25, 2026
3760 1262: Apoptosis 1395: Liver Cancer Mar 25, 2026 Mar 25, 2026
3802 1262: Apoptosis 1757: Decrease, Sperm count Jul 3, 2026 Jul 3, 2026
2198 1817: Apoptotic cell death 1633: Increase in inflammation Nov 2, 2020 Nov 2, 2020
3436 2293: Aromatase, induction 1076: Increased, circulating estrogen levels Nov 22, 2024 Dec 16, 2024
3803 2430: AhR activation 1392: Increase, Oxidative Stress Jul 9, 2026 Jul 9, 2026
3804 2430: AhR activation 2431: Impact on sirtuins-related aging signaling pathway gene expression Jul 9, 2026 Jul 9, 2026 None
3815 2430: AhR activation 80: Up Regulation, CYP1A1 Jul 9, 2026 Jul 9, 2026
3821 2430: AhR activation 1507: Activation of PPARγ Jul 9, 2026 Jul 9, 2026
2192 1814: Reactive Metabolite 1816: Mitochondrial dysfunction EMPTY Nov 2, 2020 Nov 2, 2020 None
2194 1814: Reactive Metabolite 1818: Immune cell activation Nov 2, 2020 Nov 2, 2020
3151 1814: Reactive Metabolite 177: Increase, Mitochondrial dysfunction Mar 13, 2024 Mar 13, 2024
3199 1755: beta-catenin activation 1457: EMT Apr 23, 2024 Apr 23, 2024
248 214: Bile accumulation, Pathological condition 288: Activation of specific nuclear receptors, Transcriptional change Nov 29, 2016 Dec 3, 2016
928 214: Bile accumulation, Pathological condition 87: Release, Cytokine Nov 29, 2016 Dec 3, 2016
3510 214: Bile accumulation, Pathological condition 1115: Increase, ROS Apr 3, 2025 Apr 3, 2025
3788 2427: Bile acid composition, altered 1931: Disruption of the intestinal barrier Apr 27, 2026 Apr 27, 2026
877 857: Binding as antagonist, Antagonist binding to PPARalpha ligand binding domain 858: Decreased, PPARalpha transactivation of gene expression Nov 29, 2016 Nov 29, 2016 None
666 667: Binding at picrotoxin site, iGABAR chloride channel 64: Reduction, Ionotropic GABA receptor chloride channel conductance Nov 29, 2016 Apr 29, 2019
3183 2218: Binding of (ant)agonist to liver X receptor 2221: LXR activity, altered Apr 12, 2024 Apr 12, 2024
3187 2218: Binding of (ant)agonist to liver X receptor 2115: Cholesterol metabolism Apr 12, 2024 Apr 12, 2024
3184 2219: Binding of (ant)agonist to PPAR alpha 2216: Binding of antagonist to thyroid hormone receptor Apr 12, 2024 Apr 12, 2024 None
3185 2219: Binding of (ant)agonist to PPAR alpha 2222: PPAR alpha activity, altered Apr 12, 2024 Apr 12, 2024
3188 2219: Binding of (ant)agonist to PPAR alpha 2115: Cholesterol metabolism Apr 12, 2024 Apr 12, 2024