Key Event Relationships (KERs)

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Showing 551 to 575 of 3164 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
2312 1739: Binding to ACE2 1787: Downregulation of ACE2 Mar 31, 2021 Nov 12, 2021
2452 1739: Binding to ACE2 1913: Endothelial cell dysfunction Aug 4, 2021 Aug 4, 2021 None
2522 1739: Binding to ACE2 1937: ADAM17 induction Oct 28, 2021 Oct 28, 2021 None
2020 1710: Binding to estrogen receptor (ER)-α 1711: Induction of GATA3 expression Dec 29, 2019 Aug 14, 2020
2534 1956: Binding to hERG channel 1958: Direct hERG channel blockage Dec 13, 2021 Dec 13, 2021 None
2605 1353: Binding to VGSC 1977: Altered kinetics of sodium channel Mar 21, 2022 Jul 31, 2024
1253 1201: Binding, Immunophilins 980: Inhibition, Calcineurin Activity Nov 29, 2016 Oct 25, 2017 None
287 261: Binding, SH-/selen-proteins 158: N/A, Interferences with SH-/selen-proteins Nov 29, 2016 Dec 3, 2016 None
1683 1487: Binding, SH/SeH proteins involved in protection against oxidative stress 177: Increase, Mitochondrial dysfunction Nov 9, 2017 Nov 9, 2017 None
1689 1487: Binding, SH/SeH proteins involved in protection against oxidative stress 1392: Increase, Oxidative Stress Nov 9, 2017 Feb 7, 2018 None
1765 1487: Binding, SH/SeH proteins involved in protection against oxidative stress 1538: Protection against oxidative stress, decreased Sep 13, 2018 Feb 10, 2020
2250 1831: Binding, Thyroid binding globulin in serum 1830: Displacement, Serum thyroxine (T4) from carrier protein Dec 9, 2020 Dec 9, 2020
2245 957: Binding, Transthyretin in serum 958: Displacement, Serum thyroxine (T4) from transthyretin Dec 9, 2020 Dec 9, 2020
2248 957: Binding, Transthyretin in serum 1830: Displacement, Serum thyroxine (T4) from carrier protein Dec 9, 2020 Dec 9, 2020
2269 957: Binding, Transthyretin in serum 961: Increased, Clearance of thyroxine from serum Jan 26, 2021 Jan 26, 2021 None
2271 957: Binding, Transthyretin in serum 959: Increased, Free serum thyroxine (T4) Jan 26, 2021 Jan 26, 2021 None
714 718: Binding, Tubulin 720: Disruption, Microtubule dynamics Nov 29, 2016 May 27, 2019
724 718: Binding, Tubulin 723: Altered, Chromosome number Nov 29, 2016 Dec 13, 2019
330 301: Binding, VEGF-A 304: Decreased, VegfR2 Nov 29, 2016 Dec 3, 2016 None
331 301: Binding, VEGF-A 305: Inhibition, VegfR2 Nov 29, 2016 Dec 3, 2016 None
2025 1716: STAT5 inhibition 1717: Suppression of STAT5 binding to cytokine gene promoters Jan 5, 2020 Nov 3, 2021
1755 1529: Blockade, L-Type Calcium Channels 1530: Decrease, Calcium currents Jun 19, 2018 Jun 19, 2018
3406 1529: Blockade, L-Type Calcium Channels 698: Altered, Action Potential Nov 20, 2024 Nov 20, 2024
1813 1570: Blocking of IL-1R 1572: Impaired IL-1 signaling Dec 24, 2018 Jun 25, 2019 None
1973 1676: Blood extravasation into the lungs 1679: Acute inhalation toxicity Jul 3, 2019 Jul 3, 2019 None