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Showing 1851 to 1875 of 3119 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

2966	1115: Increase, ROS	1262: Apoptosis	Jul 18, 2023	Apr 11, 2024	2 AOPs 500: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis 638: Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis
3092	1115: Increase, ROS	233: Decreased, PPAR-gamma activation	Oct 18, 2023	Oct 19, 2023	1 AOP 513: Reactive Oxygen (ROS) formation leads to cancer via Peroxisome proliferation-activated receptor (PPAR) pathway
3490	1115: Increase, ROS	1634: Increase, Oxidative DNA damage	Feb 25, 2025	Feb 25, 2025	3 AOPs 299: Deposition of energy leading to population decline via DNA oxidation and follicular atresia 311: Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis 330: Excessive reactive oxygen species production leading to mortality (4)
3491	1115: Increase, ROS	1767: Increase, Protein oxidation	Feb 25, 2025	Feb 25, 2025	1 AOP 327: Excessive reactive oxygen species production leading to mortality (1)
3492	1115: Increase, ROS	1446: Decrease, Coupling of OXPHOS	Feb 25, 2025	Feb 25, 2025	None
3494	1115: Increase, ROS	193: Decreased, Nitric Oxide	Feb 25, 2025	Feb 25, 2025	1 AOP 26: Calcium-mediated neuronal ROS production and energy imbalance
3496	1115: Increase, ROS	177: Increase, Mitochondrial dysfunction	Feb 25, 2025	Feb 25, 2025	2 AOPs 273: Mitochondrial complex inhibition leading to liver injury 636: Increase in reactive oxygen species (ROS) leading to human amyotrophic lateral sclerosis (ALS)
3505	1115: Increase, ROS	1754: Increase, porcupine-induced Wnt secretion and Wnt signaling activation	Mar 6, 2025	Jul 22, 2025	1 AOP 298: Increase in reactive oxygen species (ROS) leading to human treatment-resistant gastric cancer
3509	1115: Increase, ROS	209: Peptide Oxidation	Apr 3, 2025	Apr 3, 2025	1 AOP 27: Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11)
3513	1115: Increase, ROS	1594: Oxidation of membrane lipids	Apr 4, 2025	Apr 4, 2025	1 AOP 282: Adverse outcome pathway on photochemical toxicity initiated by light exposure
3514	1115: Increase, ROS	1595: Oxidation/denatuation of membrane proteins	Apr 4, 2025	Apr 4, 2025	1 AOP 282: Adverse outcome pathway on photochemical toxicity initiated by light exposure
3537	1115: Increase, ROS	2195: Increase, CNS Neural cell death	May 22, 2025	May 22, 2025	1 AOP 569: Decreased DNA methylation of FAM50B/PTCHD3 leading to IQ loss of children via PI3K-Akt pathway
3611	1115: Increase, ROS	1862: Decrease, Photosystem II efficiency	Sep 2, 2025	Sep 2, 2025	1 AOP 386: Deposition of ionizing energy leading to population decline via inhibition of photosynthesis
3614	1115: Increase, ROS	112: Antagonism, Estrogen receptor	Sep 3, 2025	Sep 3, 2025	1 AOP 595: Emerging OPFRS reproductive outcome pathway
3680	1115: Increase, ROS	2384: Decrease, Vascular integrity	Oct 30, 2025	Oct 30, 2025	1 AOP 613: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via increased reactive oxygen species production
3758	1115: Increase, ROS	1967: Pyroptosis	Mar 25, 2026	Mar 25, 2026	1 AOP 638: Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis
779	778: Increase, Regenerative cell proliferation (corneal cells)	779: Increase, Papillomas/carcinomas (squamous cells)	Nov 29, 2016	Dec 3, 2016	1 AOP 114: HPPD inhibition leading to corneal papillomas and carcinomas (in rat)
782	781: Increase, Regenerative cell proliferation (forestomach epithelial cells)	782: Increase, Hyperplasia (forestomach epithelial cells)	Nov 29, 2016	Dec 3, 2016	1 AOP 115: Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat)
789	787: Increase, Regenerative cell proliferation (hepatocytes)	774: Increase, Preneoplastic foci (hepatocytes)	Nov 29, 2016	Dec 3, 2016	1 AOP 118: Chronic cytotoxicity leading to hepatocellular adenomas and carcinomas (in mouse and rat)
727	734: Increase, Regenerative cell proliferation (terminal bronchiolar epithelial cells)	735: Increase, Hyperplasia (terminal bronchiolar cells)	Nov 29, 2016	Dec 3, 2016	1 AOP 109: Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse)
760	710: Increase, Regenerative cell proliferation (tubular epithelial cells)	767: Increase, Hyperplasia (renal tubular cells)	Nov 29, 2016	Dec 3, 2016	1 AOP 105: Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
785	710: Increase, Regenerative cell proliferation (tubular epithelial cells)	784: Increase, Hyperplasia (tubular epithelial cells)	Nov 29, 2016	Dec 3, 2016	1 AOP 116: Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
797	795: Increase, Regenerative cell proliferation (urothelial cells)	796: Increase, Hyperplasia (urothelial)	Nov 29, 2016	Dec 3, 2016	2 AOPs 121: Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat) 335: AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment
3730	2406: Increase, Regenerative nodule formation	2407: Increase, Cirrhosis	Feb 10, 2026	Feb 10, 2026	6 AOPs 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress 627: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction 628: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress 629: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress
280	252: Increase, Renal pathology due to VTG deposition	339: Altered, Larval development	Nov 29, 2016	Dec 3, 2016	1 AOP 29: Estrogen receptor agonism leading to reproductive dysfunction

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