AOP-Wiki

API

All KERs

Showing 501 to 525 of 3081 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

928	214: Bile accumulation, Pathological condition	87: Release, Cytokine	Nov 29, 2016	Dec 3, 2016	1 AOP 27: Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11)
3510	214: Bile accumulation, Pathological condition	1115: Increase, ROS	Apr 3, 2025	Apr 3, 2025	1 AOP 27: Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11)
877	857: Binding as antagonist, Antagonist binding to PPARalpha ligand binding domain	858: Decreased, PPARalpha transactivation of gene expression	Nov 29, 2016	Nov 29, 2016	None
666	667: Binding at picrotoxin site, iGABAR chloride channel	64: Reduction, Ionotropic GABA receptor chloride channel conductance	Nov 29, 2016	Apr 29, 2019	1 AOP 10: Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain
3183	2218: Binding of (ant)agonist to liver X receptor	2221: LXR activity, altered	Apr 12, 2024	Apr 12, 2024	1 AOP 525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
3187	2218: Binding of (ant)agonist to liver X receptor	2115: Cholesterol metabolism	Apr 12, 2024	Apr 12, 2024	1 AOP 525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
3184	2219: Binding of (ant)agonist to PPAR alpha	2216: Binding of antagonist to thyroid hormone receptor	Apr 12, 2024	Apr 12, 2024	None
3185	2219: Binding of (ant)agonist to PPAR alpha	2222: PPAR alpha activity, altered	Apr 12, 2024	Apr 12, 2024	1 AOP 525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
3188	2219: Binding of (ant)agonist to PPAR alpha	2115: Cholesterol metabolism	Apr 12, 2024	Apr 12, 2024	1 AOP 525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
3195	2219: Binding of (ant)agonist to PPAR alpha	2223: Reduced number of oligodendrocytes	Apr 12, 2024	Apr 12, 2024	1 AOP 525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
2319	1851: Binding of agonist, Angiotensin II receptor type 1 receptor (AT1R)	1115: Increase, ROS	Apr 10, 2021	Apr 10, 2021	2 AOPs 382: Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis 319: Binding to ACE2 leading to lung fibrosis
919	875: Binding of agonist, Ionotropic glutamate receptors	388: Overactivation, NMDARs	Nov 29, 2016	Nov 29, 2016	2 AOPs 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. 475: Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons
3506	875: Binding of agonist, Ionotropic glutamate receptors	2078: Loss of drebrin	Mar 9, 2025	Mar 9, 2025	1 AOP 475: Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons
360	387: Binding of agonist, NMDARs	388: Overactivation, NMDARs	Nov 29, 2016	Nov 29, 2016	None
3182	2217: Binding of antagonist to glucocorticoid hormone receptor	2220: GR antagonism	Apr 12, 2024	Apr 12, 2024	1 AOP 525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
3181	2216: Binding of antagonist to thyroid hormone receptor	1656: TR Antagnoism	Apr 12, 2024	Apr 12, 2024	1 AOP 525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
228	201: Binding of antagonist, NMDA receptors	341: Impairment, Learning and memory	Nov 29, 2016	Dec 3, 2016	None
229	201: Binding of antagonist, NMDA receptors	195: Inhibition, NMDARs	Nov 29, 2016	Jun 13, 2018	2 AOPs 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities 12: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging
1023	998: Binding of antagonist, PPAR alpha	1000: stabilization, PPAR alpha co-repressor	Nov 29, 2016	Jun 11, 2018	1 AOP 6: Antagonist binding to PPARα leading to body-weight loss
1944	1653: Binding of inhibitor, mitochondrial complex III	1542: Inhibition, Mitochondrial complex III	Jun 7, 2019	Jun 7, 2019	1 AOP 273: Mitochondrial complex inhibition leading to liver injury
1945	1654: Binding of inhibitor, mitochondrial complex IV	1543: Mitochondrial Complex IV inhibition	Jun 7, 2019	Jun 7, 2019	1 AOP 273: Mitochondrial complex inhibition leading to liver injury
1946	1655: Binding of inhibitor, mitochondrial complex V	1544: Mitochondrial Complex V inhibition	Jun 7, 2019	Jun 7, 2019	1 AOP 273: Mitochondrial complex inhibition leading to liver injury
933	888: Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I)	887: Inhibition, NADH-ubiquinone oxidoreductase (complex I)	Nov 29, 2016	Aug 25, 2017	3 AOPs 3: Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits 276: Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome 273: Mitochondrial complex inhibition leading to liver injury
1833	1580: Binding of MSAs to microtubules	1581: Disturbance in microtubule dynamic instability	Jan 29, 2019	Jan 29, 2019	1 AOP 279: Microtubule interacting drugs lead to peripheral neuropathy
3556	2307: Binding to the QB site D1 protein	1862: Decrease, Photosystem II efficiency	Aug 5, 2025	Feb 23, 2026	1 AOP 567: Binding to plastoquinone B site leading to decreased population growth rate via photosystem II inhibition

Key Event Relationships (KERs)

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