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All KERs

Showing 551 to 575 of 3081 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

714	718: Binding, Tubulin	720: Disruption, Microtubule dynamics	Nov 29, 2016	May 27, 2019	1 AOP 106: Chemical binding to tubulin in oocytes leading to aneuploid offspring
724	718: Binding, Tubulin	723: Altered, Chromosome number	Nov 29, 2016	Dec 13, 2019	1 AOP 106: Chemical binding to tubulin in oocytes leading to aneuploid offspring
330	301: Binding, VEGF-A	304: Decreased, VegfR2	Nov 29, 2016	Dec 3, 2016	None
331	301: Binding, VEGF-A	305: Inhibition, VegfR2	Nov 29, 2016	Dec 3, 2016	None
2025	1716: STAT5 inhibition	1717: Suppression of STAT5 binding to cytokine gene promoters	Jan 5, 2020	Nov 3, 2021	1 AOP 315: Inhibition of JAK3 leading to impairment of T-Cell Dependent Antibody Response
1755	1529: Blockade, L-Type Calcium Channels	1530: Decrease, Calcium currents	Jun 19, 2018	Jun 19, 2018	1 AOP 261: L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility
3406	1529: Blockade, L-Type Calcium Channels	698: Altered, Action Potential	Nov 20, 2024	Nov 20, 2024	1 AOP 552: Inhibiton of L-Type Calcium Channels leading to heart failure via QT interval prolongation and Torsades de Pointes (TdP)
1813	1570: Blocking of IL-1R	1572: Impaired IL-1 signaling	Dec 24, 2018	Jun 25, 2019	None
1973	1676: Blood extravasation into the lungs	1679: Acute inhalation toxicity	Jul 3, 2019	Jul 3, 2019	None
1170	1132: Blood loss and development of anemia, Impaired oxygen delivery and nutrient delivery to tis	1135: Reduced fitness or even mortality, Acidosis, hypovolemic shock and organ dysfunction	Nov 29, 2016	Dec 3, 2016	1 AOP 187: Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
2353	1867: Bradykinin, activated	1496: Increased proinflammatory mediators	Apr 20, 2021	Jan 14, 2022	1 AOP 392: Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation
2355	1867: Bradykinin, activated	1866: Hypofibrinolysis	Apr 20, 2021	Jan 24, 2022	1 AOP 392: Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation
2357	1867: Bradykinin, activated	1868: Hyperinflammation	Apr 20, 2021	Oct 19, 2021	1 AOP 392: Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation
3654	2093: Decreased brain T4/T3	1656: TR Antagnoism	Oct 8, 2025	Oct 8, 2025	1 AOP 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
3658	2093: Decreased brain T4/T3	381: BDNF, Reduced	Oct 8, 2025	Oct 8, 2025	1 AOP 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
2398	1879: Bulky DNA adducts, increase	155: Inadequate DNA repair	May 17, 2021	May 17, 2021	1 AOP 397: Bulky DNA adducts leading to mutations
2399	1879: Bulky DNA adducts, increase	185: Increase, Mutations	May 17, 2021	Sep 14, 2021	1 AOP 397: Bulky DNA adducts leading to mutations
1195	1149: Calcium cannot bind to the hydroxyapatite matrix of bone, Osteocalcin and other bone protei	1150: Uncarboxylated osteocalcin not incorporated into bone matrix, decreasing bone strength, Imp	Nov 29, 2016	Dec 3, 2016	None
3410	2282: Cardiac ion channels (e.g., potassium, sodium, calcium)	1961: Prolongation of Action Potential	Nov 21, 2024	Nov 21, 2024	1 AOP 519: Cardiac ion channels blockade leading to increased incidence of cardiovascular morbidity and mortality
1712	1505: Cell cycle, disrupted	1262: Apoptosis	Jan 21, 2018	Jul 28, 2021	1 AOP 212: Histone deacetylase inhibition leading to testicular atrophy
2791	1505: Cell cycle, disrupted	752: Altered, Meiotic chromosome dynamics	Oct 25, 2022	Oct 25, 2022	1 AOP 396: Deposition of ionizing energy leads to population decline via impaired meiosis
3363	1505: Cell cycle, disrupted	1821: Decrease, Cell proliferation	Oct 8, 2024	Oct 8, 2024	3 AOPs 591: DBDPE-induced DNA damage increase in liver leading to Non-alcoholic fatty liver disease via liver steatosis and inhibition of regeneration 602: Excessive reactive oxygen species leading to growth inhibition via oxidative DNA damage 603: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell cycle disruption
3662	1505: Cell cycle, disrupted	2266: Demyelination, increased	Oct 8, 2025	Oct 8, 2025	1 AOP 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
1808	1560: Cell differentiation, altered	1561: Neural tube defects	Dec 20, 2018	Dec 20, 2018	1 AOP 275: Histone deacetylase inhibition leads to neural tube defects
2603	1560: Cell differentiation, altered	1978: Microcephaly	Mar 17, 2022	Mar 17, 2022	None

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