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All KERs

Showing 1076 to 1100 of 3081 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

393	405: disrupted, ovarian cycle	330: Decrease, Fertility	Nov 29, 2016	Dec 3, 2016	None
394	405: disrupted, ovarian cycle	406: decreased, Fertility	Nov 29, 2016	Mar 18, 2025	3 AOPs 7: Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female 398: Decreased ALDH1A (RALDH) activity leading to decreased fertility via disrupted meiotic initiation of fetal oogonia 345: Androgen receptor (AR) antagonism leading to decreased fertility in females
3601	2355: Disrupted, Spermatogenesis and Sperm quality	406: decreased, Fertility	Aug 16, 2025	Aug 16, 2025	1 AOP 592: DBDPE-induced DNA strand breaks and LDH activity inhibition leading to population growth rate decline via energy metabolism disrupt and apoptosis
2615	1977: Altered kinetics of sodium channel	698: Altered, Action Potential	Mar 25, 2022	Mar 25, 2022	None
2625	1977: Altered kinetics of sodium channel	1983: Disruption in action potential generation	Mar 31, 2022	Jul 25, 2024	1 AOP 442: Binding to voltage gate sodium channels during development leads to cognitive impairment
3668	2379: Disruption, regulatory function of dopamine signaling components.	2380: Increase, dopamine transporter gene	Oct 20, 2025	Oct 20, 2025	1 AOP 611: Behavioral abnormalities due to increased expression of dopamine transporter and receptor-related genes
3669	2379: Disruption, regulatory function of dopamine signaling components.	2381: Increase, dopamine receptor gene	Oct 20, 2025	Oct 20, 2025	1 AOP 611: Behavioral abnormalities due to increased expression of dopamine transporter and receptor-related genes
3242	1983: Disruption in action potential generation	2005: neurotrasmission in development	Jun 3, 2024	Jul 31, 2024	1 AOP 442: Binding to voltage gate sodium channels during development leads to cognitive impairment
3404	1983: Disruption in action potential generation	2280: Prolonged atrioventricular (AV)	Nov 20, 2024	Nov 20, 2024	1 AOP 551: Increased Muscarinic M2 Receptor leading to Arrhythmia
3457	2300: Disruption, Glucolipid metabolism	566: impaired, Larval development	Dec 24, 2024	Dec 24, 2024	1 AOP 564: DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity.
1761	1536: Disruption, Intracellular calcium mobilization	1537: Disruption, Sarcomere assembly	Jun 21, 2018	Jun 21, 2018	1 AOP 261: L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility
921	898: Disruption, Lysosome	209: Peptide Oxidation	Nov 29, 2016	Nov 29, 2016	None
993	898: Disruption, Lysosome	177: Increase, Mitochondrial dysfunction	Nov 29, 2016	Nov 12, 2018	2 AOPs 144: Endocytic lysosomal uptake leading to liver fibrosis 530: Endocytotic lysosomal uptake leads to intestinal barrier disruption
1679	898: Disruption, Lysosome	709: Increase, Cytotoxicity (renal tubular cell)	Oct 25, 2017	Oct 25, 2017	1 AOP 257: Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity
715	720: Disruption, Microtubule dynamics	721: Disorganization, Meiotic Spindle	Nov 29, 2016	Dec 13, 2019	1 AOP 106: Chemical binding to tubulin in oocytes leading to aneuploid offspring
2955	2151: Disruption, neurotransmitter release	341: Impairment, Learning and memory	Jun 27, 2023	Apr 11, 2024	2 AOPs 499: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via disrupted neurotransmitter release 535: Binding and activation of GPER leading to learning and memory impairments
3080	2151: Disruption, neurotransmitter release	637: impaired, Learning and memory	Oct 17, 2023	Oct 17, 2023	1 AOP 471: Neuron defect induced early behavioral change
3458	2151: Disruption, neurotransmitter release	2301: Abnormal, Behavior	Dec 24, 2024	Dec 24, 2024	1 AOP 564: DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity.
2562	1682: Disruption, Progenitor cells of second heart field	1557: Reduced neural crest cell migration	Feb 8, 2022	Feb 10, 2022	1 AOP 436: Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries
1762	1537: Disruption, Sarcomere assembly	1532: Decrease, Cardiac contractility	Jun 21, 2018	Jun 21, 2018	1 AOP 261: L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility
1842	1590: Distribution of chemicals	1591: Absorption of photon energy	Feb 4, 2019	Feb 4, 2019	None
1834	1581: Disturbance in microtubule dynamic instability	1582: Impaired axonial transport	Jan 29, 2019	Jan 29, 2019	1 AOP 279: Microtubule interacting drugs lead to peripheral neuropathy
843	831: Disturbance, Lysosomal function	833: Occurrence, Cytoplasmic vacuolization (hepatocyte)	Nov 29, 2016	Dec 3, 2016	1 AOP 130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
844	831: Disturbance, Lysosomal function	835: Occurrence, Ballooning degeneration (hepatocyte)	Nov 29, 2016	Dec 3, 2016	1 AOP 130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
845	831: Disturbance, Lysosomal function	836: Occurrence, Cytoplasmic vacuolization (Bile duct cell)	Nov 29, 2016	Dec 3, 2016	1 AOP 130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity

Key Event Relationships (KERs)

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