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All KERs

Showing 1076 to 1100 of 3119 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

3703	2394: Lower survival B lymphocytes	2395: Diminished proliferation of activated B lymphocytes	Dec 3, 2025	Dec 3, 2025	1 AOP 618: PPARgamma activation leads to a diminished vaccine response
2537	1958: Direct hERG channel blockage	1960: Inhibition of Ikr	Dec 13, 2021	Dec 13, 2021	None
3145	1260: Direct mitochondrial inhibition	177: Increase, Mitochondrial dysfunction	Mar 13, 2024	Mar 13, 2024	1 AOP 205: AOP from chemical insult to cell death
737	721: Disorganization, Meiotic Spindle	752: Altered, Meiotic chromosome dynamics	Nov 29, 2016	Dec 13, 2019	1 AOP 106: Chemical binding to tubulin in oocytes leading to aneuploid offspring
2249	1830: Displacement, Serum thyroxine (T4) from carrier protein	959: Increased, Free serum thyroxine (T4)	Dec 9, 2020	Dec 9, 2020	2 AOPs 366: Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis 367: Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis
2246	958: Displacement, Serum thyroxine (T4) from transthyretin	959: Increased, Free serum thyroxine (T4)	Dec 9, 2020	Dec 9, 2020	1 AOP 152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity
3210	2225: Disrupted Lipid Storage	327: Accumulation, Fatty acid	May 8, 2024	May 28, 2024	1 AOP 529: Xenobiotic binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism leading to liver steatosis
3211	2225: Disrupted Lipid Storage	291: Accumulation, Triglyceride	May 8, 2024	May 29, 2024	1 AOP 529: Xenobiotic binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism leading to liver steatosis
3221	2227: Disrupted PPAR isoform nuclear signaling	2224: Dysregulation of transcriptional expression within PPAR signaling network	May 14, 2024	May 23, 2024	1 AOP 529: Xenobiotic binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism leading to liver steatosis
3222	2227: Disrupted PPAR isoform nuclear signaling	179: Decrease, Fatty acid β-oxidation	May 14, 2024	May 14, 2024	None
3599	2353: Disrupted, energy metabolism	2354: Activation, Apoptosis signaling	Aug 16, 2025	Aug 16, 2025	1 AOP 592: DBDPE-induced DNA strand breaks and LDH activity inhibition leading to population growth rate decline via energy metabolism disrupt and apoptosis
2481	1882: Disrupted, meiotic initiation in oocyte	1883: Decreased, ovarian reserve	Sep 13, 2021	Dec 18, 2024	1 AOP 398: Decreased ALDH1A (RALDH) activity leading to decreased fertility via disrupted meiotic initiation of fetal oogonia
393	405: disrupted, ovarian cycle	330: Decrease, Fertility	Nov 29, 2016	Dec 3, 2016	None
394	405: disrupted, ovarian cycle	406: decreased, Fertility	Nov 29, 2016	Mar 18, 2025	3 AOPs 7: Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female 398: Decreased ALDH1A (RALDH) activity leading to decreased fertility via disrupted meiotic initiation of fetal oogonia 345: Androgen receptor (AR) antagonism leading to decreased fertility in females
3601	2355: Disrupted, Spermatogenesis and Sperm quality	406: decreased, Fertility	Aug 16, 2025	Aug 16, 2025	1 AOP 592: DBDPE-induced DNA strand breaks and LDH activity inhibition leading to population growth rate decline via energy metabolism disrupt and apoptosis
2615	1977: Altered kinetics of sodium channel	698: Altered, Action Potential	Mar 25, 2022	Mar 25, 2022	None
2625	1977: Altered kinetics of sodium channel	1983: Disruption in action potential generation	Mar 31, 2022	Jul 25, 2024	1 AOP 442: Binding to voltage gate sodium channels during development leads to cognitive impairment
3668	2379: Disruption, regulatory function of dopamine signaling components.	2380: Increase, dopamine transporter gene	Oct 20, 2025	Oct 20, 2025	1 AOP 611: Behavioral abnormalities due to increased expression of dopamine transporter and receptor-related genes
3669	2379: Disruption, regulatory function of dopamine signaling components.	2381: Increase, dopamine receptor gene	Oct 20, 2025	Oct 20, 2025	1 AOP 611: Behavioral abnormalities due to increased expression of dopamine transporter and receptor-related genes
3242	1983: Disruption in action potential generation	2005: neurotrasmission in development	Jun 3, 2024	Jul 31, 2024	1 AOP 442: Binding to voltage gate sodium channels during development leads to cognitive impairment
3404	1983: Disruption in action potential generation	2280: Prolonged atrioventricular (AV)	Nov 20, 2024	Nov 20, 2024	1 AOP 551: Increased Muscarinic M2 Receptor leading to Arrhythmia
3457	2300: Disruption, Glucolipid metabolism	566: impaired, Larval development	Dec 24, 2024	Dec 24, 2024	1 AOP 564: DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity.
1761	1536: Disruption, Intracellular calcium mobilization	1537: Disruption, Sarcomere assembly	Jun 21, 2018	Jun 21, 2018	1 AOP 261: L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility
921	898: Disruption, Lysosome	209: Peptide Oxidation	Nov 29, 2016	Nov 29, 2016	None
993	898: Disruption, Lysosome	177: Increase, Mitochondrial dysfunction	Nov 29, 2016	Nov 12, 2018	2 AOPs 144: Endocytic lysosomal uptake leading to liver fibrosis 530: Endocytotic lysosomal uptake leads to intestinal barrier disruption

Key Event Relationships (KERs)

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