AOP-Wiki

API

All KERs

Showing 1851 to 1875 of 3081 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

727	734: Increase, Regenerative cell proliferation (terminal bronchiolar epithelial cells)	735: Increase, Hyperplasia (terminal bronchiolar cells)	Nov 29, 2016	Dec 3, 2016	1 AOP 109: Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse)
760	710: Increase, Regenerative cell proliferation (tubular epithelial cells)	767: Increase, Hyperplasia (renal tubular cells)	Nov 29, 2016	Dec 3, 2016	1 AOP 105: Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
785	710: Increase, Regenerative cell proliferation (tubular epithelial cells)	784: Increase, Hyperplasia (tubular epithelial cells)	Nov 29, 2016	Dec 3, 2016	1 AOP 116: Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
797	795: Increase, Regenerative cell proliferation (urothelial cells)	796: Increase, Hyperplasia (urothelial)	Nov 29, 2016	Dec 3, 2016	2 AOPs 121: Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat) 335: AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment
3730	2406: Increase, Regenerative nodule formation	2407: Increase, Cirrhosis	Feb 10, 2026	Feb 10, 2026	6 AOPs 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress 627: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction 628: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress 629: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress
280	252: Increase, Renal pathology due to VTG deposition	339: Altered, Larval development	Nov 29, 2016	Dec 3, 2016	1 AOP 29: Estrogen receptor agonism leading to reproductive dysfunction
3258	252: Increase, Renal pathology due to VTG deposition	351: Increased Mortality	Jun 24, 2024	Jun 24, 2024	1 AOP 536: Estrogen receptor agonism leading to reduced survival and population growth due to renal failure
889	869: Increase, Respiratory or Squamous Metaplasia	870: Increase, Cell Proliferation	Nov 29, 2016	Dec 1, 2016	1 AOP 136: Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors
1930	1652: Increase, SAM depletion	1620: Increase, DNA hypomethylation	May 30, 2019	May 30, 2019	None
1460	1348: Increase, seizure	1363: Increased, epilepsy	Apr 14, 2017	Apr 14, 2017	2 AOPs 215: Molecular events lead to epilepsy 471: Neuron defect induced early behavioral change
2742	2049: Increase, sex ratio (F/M)	2050: Increase, developmental abnormalities	Aug 28, 2022	Aug 28, 2022	1 AOP 465: Alcohol dehydrogenase leading to reproductive dysfunction
2684	2021: Increase, slincR expression	2020: Decrease, sox9 expression	Jun 30, 2022	Sep 8, 2022	2 AOPs 455: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development 456: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity
2690	2021: Increase, slincR expression	1559: Smaller and morphologically distorted facial cartilage structures	Jun 30, 2022	Sep 8, 2022	1 AOP 455: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development
2727	2021: Increase, slincR expression	317: Altered, Cardiovascular development/function	Aug 2, 2022	Sep 8, 2022	1 AOP 456: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity
3550	2336: Increase, SREBF1	291: Accumulation, Triglyceride	Jul 25, 2025	Jul 25, 2025	1 AOP 580: Mineralocorticoid Receptor Activation Leading to Increased Body Mass Index
3727	1489: Increase, Steatohepatitis	1271: Activation of TGF-β signaling	Feb 10, 2026	Feb 10, 2026	6 AOPs 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress 627: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction 628: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress 629: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress
1745	1525: Increase, SUR binding	1527: Increase, Cell membrane depolarization	May 24, 2018	May 24, 2018	1 AOP 361: Sulfonylureareceptor binding leading to mortality
1489	1381: Increase, surfactant	1380: Activate, mucosal defense	Apr 17, 2017	Apr 17, 2017	1 AOP 217: Gastric ulcer formation
2064	1748: Increase, the risk of acute respiratory failure	1751: Decreased mortality	Mar 17, 2020	Mar 17, 2020	None
2135	1748: Increase, the risk of acute respiratory failure	351: Increased Mortality	May 13, 2020	May 13, 2020	1 AOP 320: Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality
741	753: Increase, Thyroid-stimulating hormone (TSH)	739: Increase, Hypertrophy and proliferation (follicular cell)	Nov 29, 2016	Dec 3, 2016	None
888	868: Increase, Tissue Degeneration, Necrosis & Atrophy	869: Increase, Respiratory or Squamous Metaplasia	Nov 29, 2016	Dec 1, 2016	1 AOP 136: Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors
2178	1809: Increase, Tissue/organ damage	1521: Decrease, Growth	Nov 2, 2020	Nov 2, 2020	None
2528	1950: Increase, TNF	1949: Decrease, GLUT4	Nov 18, 2021	Nov 18, 2021	1 AOP 431: Increased tumor necrosis factor (TNF) leading to increased risk of gestational diabetes mellitus (GDM)
3671	2381: Increase, dopamine receptor gene	746: Increase, Dopaminergic activity	Oct 20, 2025	Oct 20, 2025	1 AOP 611: Behavioral abnormalities due to increased expression of dopamine transporter and receptor-related genes

Key Event Relationships (KERs)

All KERs