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Showing 2176 to 2200 of 3081 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

2491	1497: Recruitment of inflammatory cells	1931: Disruption of the intestinal barrier	Oct 19, 2021	Oct 19, 2021	None
2492	1497: Recruitment of inflammatory cells	1932: GI disorders	Oct 19, 2021	Oct 19, 2021	None
2543	1497: Recruitment of inflammatory cells	1954: Gut dysbiosis	Dec 15, 2021	Dec 15, 2021	None
2658	1497: Recruitment of inflammatory cells	780: Increase, Cytotoxicity (epithelial cells)	May 25, 2022	May 25, 2022	1 AOP 451: Interaction with lung resident cell membrane components leads to lung cancer
2761	1497: Recruitment of inflammatory cells	1496: Increased proinflammatory mediators	Sep 1, 2022	Sep 1, 2022	1 AOP 468: Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death)
2903	1497: Recruitment of inflammatory cells	1633: Increase in inflammation	May 4, 2023	May 4, 2023	1 AOP 493: ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity
1215	1163: Increased, Reproductive Success	1164: Increased, Population	Nov 29, 2016	Dec 3, 2016	2 AOPs 195: 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase 204: 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase
1308	1242: Increased, Second Messenger Production	1191: Increased, Non-genomic signaling	Nov 29, 2016	Dec 3, 2016	1 AOP 200: Estrogen receptor activation leading to breast cancer
1090	1049: Increased, secrection of FSH from anterior pituitary	1051: Hyperplasia, ovarian stromal cells	Nov 29, 2016	Dec 3, 2016	1 AOP 165: Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse
1091	1049: Increased, secrection of FSH from anterior pituitary	1052: Hyperplasia, ovarian epithelium	Nov 29, 2016	Dec 3, 2016	1 AOP 165: Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse
1088	1047: Increased, secretion of GnRH from hypothalamus	1049: Increased, secrection of FSH from anterior pituitary	Nov 29, 2016	Dec 3, 2016	1 AOP 165: Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse
1089	1047: Increased, secretion of GnRH from hypothalamus	1050: Increased, secretion of LH from anterior pituitary	Nov 29, 2016	Mar 1, 2022	2 AOPs 165: Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse 440: Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia
3715	1047: Increased, secretion of GnRH from hypothalamus	2137: Increase, Gonadotropins concentration in plasma	Jan 29, 2026	Feb 3, 2026	1 AOP 623: Activation, estrogen receptor alpha leads to persistent vaginal cornification via increased kisspeptin release
1092	1050: Increased, secretion of LH from anterior pituitary	1051: Hyperplasia, ovarian stromal cells	Nov 29, 2016	Dec 3, 2016	1 AOP 165: Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse
2581	1050: Increased, secretion of LH from anterior pituitary	1972: Increased, Steroidogenic acute regulatory protein (StAR)	Feb 26, 2022	Mar 1, 2022	1 AOP 440: Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia
1074	1032: Increased, secretion of local growth factors	1033: Increased, proliferation of mesenchymal cells	Nov 29, 2016	Dec 3, 2016	1 AOP 163: PPARgamma activation leading to sarcomas in rats, mice, and hamsters
1075	1032: Increased, secretion of local growth factors	1034: Increased, IGF-1 (mouse)	Nov 29, 2016	Dec 3, 2016	1 AOP 163: PPARgamma activation leading to sarcomas in rats, mice, and hamsters
1129	1032: Increased, secretion of local growth factors	1089: Increased, Cell Proliferation (mesothelium)	Nov 29, 2016	Dec 3, 2016	1 AOP 171: Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat.
1624	1032: Increased, secretion of local growth factors	1456: Differentiation of fibroblasts	Jul 26, 2017	Jul 26, 2017	None
1625	1032: Increased, secretion of local growth factors	1457: EMT	Jul 26, 2017	Jul 26, 2017	None
1703	1496: Increased proinflammatory mediators	1497: Recruitment of inflammatory cells	Jan 5, 2018	May 18, 2023	5 AOPs 173: Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis 392: Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation 409: Frustrated phagocytosis leads to malignant mesothelioma 451: Interaction with lung resident cell membrane components leads to lung cancer 468: Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death)
2053	1496: Increased proinflammatory mediators	1438: Increased transcription of genes encoding acute phase proteins	Mar 1, 2020	Jan 20, 2025	1 AOP 237: Substance interaction with lung resident cell membrane components leading to atherosclerosis
2061	1496: Increased proinflammatory mediators	1750: Increased inflammatory immune responses	Mar 10, 2020	Mar 10, 2020	1 AOP 320: Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality
2301	1496: Increased proinflammatory mediators	1849: Impaired gustatory nerve	Mar 28, 2021	Mar 28, 2021	None
2307	1496: Increased proinflammatory mediators	68: Increase, Collagen accumulation	Mar 30, 2021	Mar 30, 2021	2 AOPs 382: Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis 319: Binding to ACE2 leading to lung fibrosis

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