Prototypical Stressors

Showing 251 to 275 of 853 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

741	DCA		335: AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment
742	DCPMU		335: AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment
443	Decitabine	Decitabine, CAS-RN: 2353-33-5, DTXSID7030432	2 AOPs 290: Mitochondrial ATP synthase antagonism leading to growth inhibition (1) 291: Mitochondrial ATP synthase antagonism leading to growth inhibition (2)
850	Deguelin	Deguelin, CAS-RN: 522-17-8, DTXSID10200231	3: Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits
636	Dehydroxymethylepoxyquinomicin (DHMEQ)		277: Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response
492	Dexamethasone	Dexamethasone, CAS-RN: 50-02-2, DTXSID3020384	2 AOPs 277: Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response 334: Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration
485	Dexamethosone		None
435	Dexamethosone, IL-1 receptor antagonist（IL-1Ra）(Anakinra), anti-IL-1b antibod (Canakinumab), soluble IL-1R (Rilonacept).		None
437	Dexamethosone, IL-1 receptor antagonist（IL-1Ra）(Anakinra), anti-IL-1b antibod (Canakinumab), soluble IL-1R (Rilonacept).		None
570	di-n-heptyl phthalate		None
566	di-n-hexyl phthalate		None
65	Di(2-ethylhexyl) phthalate	Di(2-ethylhexyl) phthalate, CAS-RN: 117-81-7, DTXSID5020607	3 AOPs 457: Succinate dehydrogenase inhibition leading to increased insulin resistance through reduction in circulating thyroxine 575: Decreased testosterone synthesis leading to increased nipple retention (NR) in male (rodent) offspring 570: Decreased testosterone synthesis leading to hypospadias in male (mammalian) offspring
816	Diazinon		559: Inhibition of acetylcholinesterase (AChE) leading to arrhythmias
533	Dibefurin		154: Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response
147	Dibenzo-p-dioxin	Dibenzo-p-dioxin, CAS-RN: 262-12-4, DTXSID8020410	131: Aryl hydrocarbon receptor activation leading to uroporphyria
235	Dibenzo[B,F][1,4]Oxazepine		196: Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation
159	dibenzofuran	Dibenzofuran, CAS-RN: 132-64-9, DTXSID2021993	None
14	Dibutyl phthalate	1,2-Benzenedicarboxylic acid, dibutyl ester, CAS-RN: 84-74-2, DTXSID2021781	3 AOPs 307: Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring 575: Decreased testosterone synthesis leading to increased nipple retention (NR) in male (rodent) offspring 570: Decreased testosterone synthesis leading to hypospadias in male (mammalian) offspring
134	Dichloroacetic Acid	Dichloroacetic acid, CAS-RN: 79-43-6, DTXSID2020428	None
15	Diclofenac sodium	Diclofenac sodium, CAS-RN: 15307-79-6, DTXSID3037208	2 AOPs 177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality 186: unknown MIE leading to renal failure and mortality
567	Dicyclohexyl phthalate	Dicyclohexyl phthalate, CAS-RN: 84-61-7, DTXSID5025021	None
115	Dieldrin	Dieldrin, CAS-RN: 60-57-1, DTXSID9020453	10: Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain
667	Diesel engine exhaust	Diesel engine exhaust, CAS-RN: NOCAS, DTXSID1024043	2 AOPs 411: Oxidative stress Leading to Decreased Lung Function 451: Interaction with lung resident cell membrane components leads to lung cancer
767	Diethyl maleate	Diethyl maleate, CAS-RN: 141-05-9, DTXSID8020464	492: Glutathione conjugation leading to reproductive dysfunction via oxidative stress
16	Diethyl nitrosamine	N-Nitrosodiethylamine, CAS-RN: 55-18-5, DTXSID2021028	None