Prototypical Stressors

Showing 251 to 275 of 871 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

294	Cyclosporin		2 AOPs 154: Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response 622: Calcineurin inhibitor induced nephrotoxicity leading to kidney failure
591	Cyclosporin, FK506, Basiliximab, PFOA (perfluorooctanoic acid)		None
108	Cyfluthrin	Cyfluthrin, CAS-RN: 68359-37-5, DTXSID5035957	None
135	Cyp2f2 substrates		None
103	Cypermethrin	Cypermethrin, CAS-RN: 52315-07-8, DTXSID1023998	561: Aromatase induction leading to estrogen receptor alpha activation via increased estradiol
560	Cyproterone acetate	Cyproterone acetate, CAS-RN: 427-51-0, DTXSID5020366	None
484	D-2-hydroxyglutarate		None
121	D-limonene	D-Limonene, CAS-RN: 5989-27-5, DTXSID1020778	None
75	Daidzein	7,4'-Dihydroxyisoflavone, CAS-RN: 486-66-8, DTXSID9022310	None
631	Danger Associated Molecular Patters (DAMPs)		377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
312	Dazornet		242: Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
741	DCA		335: AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment
742	DCPMU		335: AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment
443	Decitabine	Decitabine, CAS-RN: 2353-33-5, DTXSID7030432	2 AOPs 290: Mitochondrial ATP synthase antagonism leading to growth inhibition (1) 291: Mitochondrial ATP synthase antagonism leading to growth inhibition (2)
850	Deguelin	Deguelin, CAS-RN: 522-17-8, DTXSID10200231	3: Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits
636	Dehydroxymethylepoxyquinomicin (DHMEQ)		277: Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response
492	Dexamethasone	Dexamethasone, CAS-RN: 50-02-2, DTXSID3020384	2 AOPs 277: Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response 334: Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration
485	Dexamethosone		None
435	Dexamethosone, IL-1 receptor antagonist（IL-1Ra）(Anakinra), anti-IL-1b antibod (Canakinumab), soluble IL-1R (Rilonacept).		None
437	Dexamethosone, IL-1 receptor antagonist（IL-1Ra）(Anakinra), anti-IL-1b antibod (Canakinumab), soluble IL-1R (Rilonacept).		None
570	di-n-heptyl phthalate		None
566	di-n-hexyl phthalate		None
65	Di(2-ethylhexyl) phthalate	Di(2-ethylhexyl) phthalate, CAS-RN: 117-81-7, DTXSID5020607	3 AOPs 457: Succinate dehydrogenase inhibition leading to increased insulin resistance through reduction in circulating thyroxine 575: Decreased testosterone synthesis leading to increased nipple retention (NR) in male (rodent) offspring 570: Decreased testosterone synthesis leading to hypospadias in male (mammalian) offspring
816	Diazinon		559: Inhibition of acetylcholinesterase (AChE) leading to arrhythmias
533	Dibefurin		154: Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response