Prototypical Stressors

Showing 751 to 775 of 853 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

251	TCPOBOP		107: Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat
286	Tebuconazole	Tebuconazole, CAS-RN: 107534-96-3, DTXSID9032113	None
164	Tebufenozide	Tebufenozide, CAS-RN: 112410-23-8, DTXSID4034948	2 AOPs 4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1 342: Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade
852	Tebufenpyrad	Tebufenpyrad, CAS-RN: 119168-77-3, DTXSID0034223	3: Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits
827	Technical chlordane	Technical chlordane, CAS-RN: 12789-03-6, DTXSID5023954	561: Aromatase induction leading to estrogen receptor alpha activation via increased estradiol
370	Teflubenzuron	Teflubenzuron, CAS-RN: 83121-18-0, DTXSID6042440	None
187	Telmisartan	Telmisartan, CAS-RN: 144701-48-4, DTXSID8023636	None
141	Tembotrione	Tembotrione, CAS-RN: 335104-84-2, DTXSID5047037	None
449	Temozolomide	Temozolomide, CAS-RN: 85622-93-1, DTXSID5043714	2 AOPs 290: Mitochondrial ATP synthase antagonism leading to growth inhibition (1) 291: Mitochondrial ATP synthase antagonism leading to growth inhibition (2)
322	Tenofovir	Tenofovir, CAS-RN: 147127-20-6, DTXSID9040132	256: Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity
323	Tenofovir disoproxil fumarate	Tenofovir disoproxil fumarate, CAS-RN: 202138-50-9, DTXSID5050426	256: Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity
706	Terfenadine	Terfenadine, CAS-RN: 50679-08-8, DTXSID2023642	2 AOPs 519: Cardiac ion channels blockade leading to increased incidence of cardiovascular morbidity and mortality 555: Inhibition, Ether-a-go-go (ERG) Voltage-Gated Potassium Channel leading to heart failure
457	tert-Butyl hydroperoxide	tert-Butyl hydroperoxide, CAS-RN: 75-91-2, DTXSID9024693	296: Oxidative DNA damage leading to chromosomal aberrations and mutations
524	testJF		None
525	testJF2		None
708	Tetraarsenic trioxide	Tetraarsenic trioxide, CAS-RN: 83527-54-2, DTXSID80232428	None
261	Tetrabromobisphenol A	3,3',5,5'-Tetrabromobisphenol A, CAS-RN: 79-94-7, DTXSID1026081	2 AOPs 152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity 504: SULT1E1 inhibition leading to uterine adenocarcinoma via increased estrogen availability at target organ level
781	Tetrabromobisphenol A bis(2-hydroxyethyl) ether	Tetrabromobisphenol A bis(2-hydroxyethyl) ether, CAS-RN: 4162-45-2, DTXSID4038922	None
792	Tetracaine		553: Inhibition of Voltage-gated sodium channels (Na⁺ channels) leading to heart failure
88	Tetraconazole	Tetraconazole, CAS-RN: 112281-77-3, DTXSID8034956	None
204	Tetrahydrocannabinol	1-trans-delta-9-Tetrahydrocannabinol, CAS-RN: 1972-08-3, DTXSID6021327	None
94	Tetrodotoxin		553: Inhibition of Voltage-gated sodium channels (Na⁺ channels) leading to heart failure
794	Tetrodotoxin derivatives		553: Inhibition of Voltage-gated sodium channels (Na⁺ channels) leading to heart failure
806	Thapsigargin		556: Decreased Na/K ATPase activity leading to heart failure
798	Theophylline		554: β-adrenergic receptor agonists leading to arrhythmias.