Prototypical Stressors

Showing 251 to 275 of 855 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

440	Photoreactive chemicals		282: Adverse outcome pathway on photochemical toxicity initiated by light exposure
499	Photoactivated chemicals		None
96	Phenytoin		None
182	Phenylbutazone	4-Butyl-1,2-diphenyl-3,5-Pyrazolidinedione, CAS-RN: 50-33-9, DTXSID9021136	177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
133	Phenobarbital	Phenobarbital, CAS-RN: 50-06-6, DTXSID5021122	2 AOPs 162: Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse 107: Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat
433	Phenethyl isothiocyanate	Phenethyl isothiocyanate, CAS-RN: 2257-09-2, DTXSID5021120	None
46	Phenanthrene	Phenanthrene, CAS-RN: 85-01-8, DTXSID6024254	None
579	PF915275		348: Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased population trajectory
587	PF-06651600 (CAS No：1792180-81-4), RB1		None
585	PF-06651600 (CAS No：1792180-81-4),		315: Inhibition of JAK3 leading to impairment of T-Cell Dependent Antibody Response
104	Permethrin	Permethrin, CAS-RN: 52645-53-1, DTXSID8022292	None
175	PERFLUOROOCTANOIC ACID		2 AOPs 166: PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse 37: PPARα activation leading to hepatocellular adenomas and carcinomas in rodents
771	Perfluorooctanesulfonic acid	Perfluorooctanesulfonic acid, CAS-RN: 1763-23-1, DTXSID3031864	529: Xenobiotic binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism leading to liver steatosis
259	Perflourinated chemicals		152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity
66	Perchlorate	Perchlorate, CAS-RN: 14797-73-0, DTXSID6024252	2 AOPs 176: Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment
773	Per- and Polyfluorinated Substances (PFAS)		529: Xenobiotic binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism leading to liver steatosis
709	Pentamidine	Pentamidine, CAS-RN: 100-33-4, DTXSID7023431	None
600	Pentachlorophenol	Pentachlorophenol, CAS-RN: 87-86-5, DTXSID7021106	263: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation
152	Penicillin		None
685	Pebulate	Pebulate, CAS-RN: 1114-71-2, DTXSID8021199	None
768	PCB 126		2 AOPs 458: AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals 459: AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
632	Pathogen Associated Molecular Patterns (PAMPs)		377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
429	Parthenolide	Parthenolide, CAS-RN: 20554-84-1, DTXSID2040579	None
45	Parathion	Parathion, CAS-RN: 56-38-2, DTXSID7021100	559: Inhibition of acetylcholinesterase (AChE) leading to arrhythmias
44	Paraquat	Paraquat, CAS-RN: 4685-14-7, DTXSID3034799	593: Redox cycling of a chemical by mitochondria leads to degeneration of nigrostriatal dopaminergic neurons