Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 76 to 100 of 1139 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
76 increased acetylcholine (CHEBI:15355) 10: Acetylcholine accumulation in synapses
77 increased atrioventricular block (MESH:D054537) 444: Increased, Atrioventricular block and bradycardia
78 increased decreased heart rate (MESH:D001919) 444: Increased, Atrioventricular block and bradycardia
79 increased respiratory distress (MP:0001954) 445: Respiratory distress/arrest
80 increased ataxia (MP:0001393)
81 increased hyperactivity (MP:0001399)
82 increased paralysis (MP:0000753)
83 decreased population growth rate (PCO:0000008)
84 occurrence protein binding (GO:0005515) Selenium-Binding Proteins (MESH:D051137) 261: Binding, SH-/selen-proteins
85 disrupted protein domain specific binding (GO:0019904) 158: N/A, Interferences with SH-/selen-proteins
86 decreased glutathione (CHEBI:16856) None
87 occurrence oxidative stress (MP:0003674) None
88 increased neuron death in response to oxidative stress (GO:0036475) 191: Neuronal dysfunction
89 increased peroxisome proliferator activated receptor signaling pathway (GO:0035357) peroxisome proliferator-activated receptor alpha (PR:000013056) 227: Activation, PPARĪ±
90 decreased gene expression (GO:0010467) STAR (PR:000015715) 266: Decrease, Steroidogenic acute regulatory protein (STAR)
91 decreased gene expression (GO:0010467) translocator protein (PR:000016757) 289: Decrease, Translocator protein (TSPO)
92 decreased mitochondrial transport (GO:0006839) cholesterol (CHEBI:16113) 447: Reduction, Cholesterol transport in mitochondria
93 decreased testosterone biosynthetic process (GO:0061370) testosterone (CHEBI:17347)
94 decreased testosterone (CHEBI:17347)
95 morphological change male reproductive organ (UBERON:0003135) 348: Malformation, Male reproductive tract
96 decreased androgen receptor activity (GO:0004882) androgen receptor (PR:000004191)
97 abnormal Wnt signaling pathway (GO:0016055) Wnt signalosome (GO:1990909) 310: Alteration, Wnt pathway
98 arrested developmental process (GO:0032502) male reproductive organ (UBERON:0003135) 240: Feminisation or incomplete development, Primary and accessory male sex organs
99 decreased regulation of gene expression (GO:0010468) androgen receptor (PR:000004191) 286: Altered, Transcription of genes by the androgen receptor
100 decreased fertility (MESH:D005298)