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All Key Events

Showing 826 to 850 of 1907 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1274	Production of α-smooth muscle actin Short Name Production of α-smooth muscle actin	0	Cellular	Feb 15, 2017	Feb 15, 2017	None
1275	Collagen Deposition Short Name Collagen Deposition	0	Tissue	Feb 15, 2017	Feb 15, 2017	206: Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis
1276	Lung fibrosis Short Name Lung fibrosis	0	Organ	Feb 15, 2017	Dec 26, 2017	5 AOPs 206: Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis 319: Binding to ACE2 leading to lung fibrosis 382: Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis 414: Aryl hydrocarbon receptor activation leading to lung fibrosis through TGF-β dependent fibrosis toxicity pathway 415: Aryl hydrocarbon receptor activation leading to lung fibrosis through IL-6 toxicity pathway
1277	Reproductive failure Short Name Reproductive failure	1	Individual	Feb 15, 2017	Feb 15, 2017	4 AOPs 207: NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans 208: Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) and Transforming growth factor (TGF)-beta pathways activation leading to reproductive failure 210: Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building 594: Micro plastic effect on reproduction
1279	Increase, Oxidative Stress / Activation, PMK-1 P38 MAPK Short Name	2	Cellular	Feb 15, 2017	Sep 16, 2017	207: NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans
1280	Activation, HIF-1 Short Name Activation, HIF-1	1	Cellular	Feb 15, 2017	Sep 16, 2017	207: NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans
1281	Increased, DNA Damage-Repair Short Name Increased, DNA Damage-Repair	1	Cellular	Feb 15, 2017	Sep 16, 2017	2 AOPs 207: NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans 592: DBDPE-induced DNA strand breaks and LDH activity inhibition leading to population growth rate decline via energy metabolism disrupt and apoptosis
1282	Activation, JAK/STAT pathway Short Name Activation, JAK/STAT pathway	2	Cellular	Feb 15, 2017	Sep 16, 2017	208: Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) and Transforming growth factor (TGF)-beta pathways activation leading to reproductive failure
1283	Activation, TGF-beta pathway Short Name Activation, TGF-beta pathway	1	Cellular	Feb 15, 2017	Sep 16, 2017	3 AOPs 208: Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) and Transforming growth factor (TGF)-beta pathways activation leading to reproductive failure 347: Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis 622: Calcineurin inhibitor induced nephrotoxicity leading to kidney failure
1284	Up Regulation, SREBF2 Short Name Up Regulation, SREBF2	1	Cellular	Feb 15, 2017	Sep 16, 2017	2 AOPs 209: Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP 401: G protein-coupled estrogen receptor 1 (GPER) signal pathway in the lipid metabolism disrupting effects
1285	Up Regulation, Unsaturated fatty acid Short Name Up Regulation, Unsaturated fatty acid	1	Cellular	Feb 15, 2017	Sep 16, 2017	209: Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP
1286	Down Regulation, GSS and GSTs gene Short Name Down Regulation, GSS and GSTs gene	2	Cellular	Feb 15, 2017	Sep 16, 2017	209: Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP
1287	Glutathione synthesis Short Name Glutathione synthesis	1	Cellular	Feb 15, 2017	Sep 16, 2017	209: Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP
1288	Activation, 3-hydroxy-3-methylglutaryl-CoA reductase gene Short Name	1	Cellular	Feb 15, 2017	Sep 16, 2017	2 AOPs 209: Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP 594: Micro plastic effect on reproduction
1289	Perturbation of cholesterol Short Name Perturbation of cholesterol	1	Cellular	Feb 15, 2017	Sep 16, 2017	209: Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP
1290	Glutathione homeostasis Short Name Glutathione homeostasis	1	Cellular	Feb 15, 2017	Sep 16, 2017	209: Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP
1291	Hepatotoxicity Short Name Hepatotoxicity	0	Cellular	Feb 15, 2017	Feb 15, 2017	209: Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP
1292	Activation, JNK Short Name Activation, JNK	1	Cellular	Feb 15, 2017	Sep 16, 2017	2 AOPs 210: Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building 347: Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis
1293	Activation, FOXO Short Name Activation, FOXO	1	Cellular	Feb 15, 2017	Sep 16, 2017	2 AOPs 210: Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building 591: DBDPE-induced DNA damage increase in liver leading to Non-alcoholic fatty liver disease via liver steatosis and inhibition of regeneration
1294	Inhibition, Wnt pathway Short Name Inhibition, Wnt pathway	1	Cellular	Feb 15, 2017	Sep 16, 2017	210: Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building
1295	Defect of Embryogenesis Short Name Defect of Embryogenesis	1	Tissue	Feb 15, 2017	Sep 16, 2017	210: Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building
1296	Increase, insulin Short Name Increase, insulin	0	Molecular	Apr 12, 2017	Apr 12, 2017	None
1297	Activation, insulin receptor Short Name Activation, insulin receptor	0	Molecular	Apr 12, 2017	Apr 12, 2017	None
1298	Activation, mTORC2 Short Name Activation, mTORC2	0	Molecular	Apr 12, 2017	Apr 12, 2017	None
1299	Activation, AKT Short Name Activation, AKT	0	Molecular	Apr 12, 2017	Apr 12, 2017	401: G protein-coupled estrogen receptor 1 (GPER) signal pathway in the lipid metabolism disrupting effects