AOP-Wiki

API

All Key Events

Showing 1676 to 1700 of 1907 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

2176	Decreased endothelial cell proliferation Short Name	0	Cellular	Aug 21, 2023	Aug 21, 2023	None
2177	Adhesion disfunction Short Name Adhesion disfunction	0	Cellular	Aug 21, 2023	Aug 21, 2023	None
2178	Vascular barrier disruption Short Name Vascular barrier disruption	0	Tissue	Aug 21, 2023	Aug 21, 2023	511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
2179	Impaired Platelet Aggregation Short Name Impaired Platelet Aggregation	0	Tissue	Aug 21, 2023	Aug 21, 2023	511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
2180	Immune mechanisms antagonized by viral proteins Short Name immune mechanisms antagonized	5	Molecular	Aug 23, 2023	Dec 13, 2023	506: Binding of Influenza A Virus (IAV) to Sialic Acid Glycan Receptor leads to viral infection proliferation
2181	Angiogenesis dysfunction Short Name Angiogenesis dysfunction	0	Organ	Aug 28, 2023	Aug 28, 2023	5 AOPs 511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects 509: Nrf2 inhibition leading to vascular disrupting effects through activating apoptosis signal pathway and mitochondrial dysfunction 510: Demethylation of PPAR promotor leading to vascular disrupting effects 507: Nrf2 inhibition leading to vascular disrupting effects via inflammation pathway 508: Nrf2 inhibition leading to vascular disrupting effects through activating HIF1α, Semaphorin 6A, and Dll4-Notch pathway
2182	Phenotype switching of vascular smooth muscle cells Short Name VSMC phenotype switching	0	Cellular	Sep 4, 2023	Sep 4, 2023	None
2183	Increased incidence of vascular calcification and atherosclerosis morbidity Short Name	0	Population	Sep 4, 2023	Nov 14, 2023	None
2184	Apoptosis of vascular smooth muscle cells Short Name VSMC apoptosis	0	Cellular	Sep 4, 2023	Sep 4, 2023	None
2185	Proliferation of vascular smooth muscle cells Short Name VSMC proliferation	0	Cellular	Sep 5, 2023	Sep 5, 2023	None
2186	Ryanodine receptor activation Short Name Activation, RyR	0	Molecular	Sep 8, 2023	May 29, 2025	490: Co-activation of IP3R and RyR leads to reduced IQ and increased socio-economic burden through non-cholinergic mechanisms
2187	Opening, voltage-gated calcium channels Short Name Opening VGCCs	0	Molecular	Sep 14, 2023	Sep 14, 2023	464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
2188	Activation, caspases Short Name Caspase activation	0	Cellular	Sep 14, 2023	Sep 14, 2023	464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
2189	Development-related pathway alterations Short Name Development-related pathway alterations	0	Cellular	Sep 16, 2023	Sep 17, 2023	None
2190	Cardiomyocyte differentiation inhibition Short Name	0	Cellular	Sep 16, 2023	Sep 16, 2023	None
2191	Inhibition of the Wnt/β-catenin pathway Short Name	0	Cellular	Sep 18, 2023	Sep 18, 2023	None
2192	Influenza A Virus production increased Short Name IAV production increased	4	Molecular	Oct 2, 2023	Jan 29, 2024	506: Binding of Influenza A Virus (IAV) to Sialic Acid Glycan Receptor leads to viral infection proliferation
2193	Influenza A Virus (IAV) budding Short Name IAV budding	1	Cellular	Oct 2, 2023	Jan 29, 2024	506: Binding of Influenza A Virus (IAV) to Sialic Acid Glycan Receptor leads to viral infection proliferation
2194	Influenza A Virus (IAV) shedding and transmission Short Name infection proliferation	1	Individual	Oct 2, 2023	Oct 2, 2023	506: Binding of Influenza A Virus (IAV) to Sialic Acid Glycan Receptor leads to viral infection proliferation
2195	Increase, CNS Neural cell death Short Name Increase, CNS Neural cell death	0	Cellular	Oct 17, 2023	Oct 17, 2023	2 AOPs 471: Neuron defect induced early behavioral change 569: Decreased DNA methylation of FAM50B/PTCHD3 leading to IQ loss of children via PI3K-Akt pathway
2196	Decrease, elavl3 Short Name Decrease, elavl3	0	Molecular	Oct 17, 2023	Oct 17, 2023	471: Neuron defect induced early behavioral change
2197	Decrease, sox10 Short Name Decrease, sox10	0	Molecular	Oct 17, 2023	Oct 17, 2023	471: Neuron defect induced early behavioral change
2198	Decrease, mbp Short Name Decrease, mbp	0	Molecular	Oct 17, 2023	Oct 17, 2023	471: Neuron defect induced early behavioral change
2199	Increased, Expression of LXR activated genes Short Name	1	Molecular	Dec 7, 2023	Mar 29, 2024	518: Liver X Receptor (LXR) activation leads to liver steatosis
2200	decline, neural progenitor cells Short Name decline, neural progenitor cells	0	Organ	Jan 10, 2024	Jan 10, 2024	441: Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation