AOP-Wiki

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All Key Events

Showing 1726 to 1750 of 1907 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

2226	Stressor binding PPAR isoforms Short Name Binding PPAR isoforms	1	Molecular	May 8, 2024	May 22, 2024	529: Xenobiotic binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism leading to liver steatosis
2227	Disrupted PPAR isoform nuclear signaling Short Name	1	Molecular	May 14, 2024	May 22, 2024	529: Xenobiotic binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism leading to liver steatosis
2228	Cerebellar gene expression. Altered Short Name Altered cerebellar gene expression	0	Molecular	Jun 6, 2024	Jun 6, 2024	532: Retinoic acid receptor agonism during cerebellar development leading to impaired locomotor function
2229	Cerebellar neuronal differentiation. Decreased Short Name	0	Organ	Jun 6, 2024	Jun 6, 2024	532: Retinoic acid receptor agonism during cerebellar development leading to impaired locomotor function
2230	Cerebellar hypoplasia Short Name Cerebellar hypoplasia	0	Tissue	Jun 6, 2024	Jun 6, 2024	532: Retinoic acid receptor agonism during cerebellar development leading to impaired locomotor function
2231	Locomotor function. Impaired Short Name Impaired locomotor function	0	Population	Jun 6, 2024	Jun 6, 2024	2 AOPs 532: Retinoic acid receptor agonism during cerebellar development leading to impaired locomotor function 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
2232	Antagonism, Retinoic acid receptors Short Name RAR antagonism	0	Molecular	Jun 6, 2024	Jun 6, 2024	533: Retinoic acid receptor antagonism during neurodevelopment leading to impaired learning and memory
2233	Decreased, ERαβ heterodimers Short Name Decreased, ERαβ heterodimers	0	Molecular	Jun 19, 2024	Jun 19, 2024	535: Binding and activation of GPER leading to learning and memory impairments
2234	Malignant transformation of cells Short Name Malignant transformation of cells	0	Cellular	Jun 26, 2024	Jun 26, 2024	None
2235	Increased incidence and mortality of liver diseases among children Short Name	0	Population	Jun 26, 2024	Jun 26, 2024	None
2236	Decreased, Sodium uptake in gills Short Name Decreased, sodium uptake in gills	1	Cellular	Jul 8, 2024	Dec 3, 2024	539: Decreased Sodium/Potassium ATPase activity leads to Heart failure
2237	Decreased, Plasma sodium concentrations Short Name Decreased, Plasma sodium concentrations	1	Tissue	Jul 8, 2024	Dec 3, 2024	539: Decreased Sodium/Potassium ATPase activity leads to Heart failure
2238	Increased, Blood viscosity Short Name Increased, Blood viscosity	1	Tissue	Jul 8, 2024	Dec 3, 2024	539: Decreased Sodium/Potassium ATPase activity leads to Heart failure
2239	Increased, Cardiac stress Short Name Increased, Cardiac stress	1	Organ	Jul 8, 2024	Dec 3, 2024	539: Decreased Sodium/Potassium ATPase activity leads to Heart failure
2240	The NO synthase pathway activation Short Name The NO synthase pathway activation	0	Cellular	Jul 9, 2024	Jul 9, 2024	538: Adverse outcome pathway of PFAS-induced vascular disrupting effects via activating oxidative stress related pathways
2241	Ferroptosis related pathways activation Short Name Ferroptosis related pathways activation	0	Cellular	Jul 9, 2024	Jul 9, 2024	538: Adverse outcome pathway of PFAS-induced vascular disrupting effects via activating oxidative stress related pathways
2242	Abnormality, dendritic spine morphology Short Name Dendritic spine abnormality	4	Cellular	Jul 14, 2024	Mar 12, 2025	475: Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons
2243	Succinate Accumulation Short Name Succinate Accumulation	0	Cellular	Jul 18, 2024	Jul 18, 2024	2 AOPs 474: Succinate dehydrogenase inactivation leads to cancer by promoting EMT 546: Succinate dehydrogenase inactivation leads to cancer through hypoxic-like mechanisms
2244	Altered Stress Response Signaling Short Name Altered Stress Response Signaling	1	Molecular	Jul 24, 2024	Nov 15, 2024	2 AOPs 470: Deposition of energy leads to abnormal vascular remodeling 483: Deposition of Energy Leading to Learning and Memory Impairment
2245	Altered Cell Differentiation Signaling Short Name Altered cell differentiation signaling	2	Molecular	Jul 24, 2024	Apr 18, 2025	2 AOPs 482: Deposition of energy leading to occurrence of bone loss 334: Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration
2246	Increased sympathetic nerve activity Short Name Increased sympathetic nerve activity	0	Cellular	Jul 29, 2024	Jul 29, 2024	None
2247	Increased incidence of cerebrovascular morbidility and mortality in the general population Short Name	0	Population	Jul 29, 2024	Jul 29, 2024	None
2248	Increased stress hormone Short Name Increased stress hormone	0	Cellular	Jul 29, 2024	Jul 29, 2024	None
2249	Activation of sensory receptors Short Name Activation of sensory receptors	0	Molecular	Jul 29, 2024	Jul 29, 2024	None
2250	17β-Hydroxysteroid dehydrogenase 2, inhibition Short Name HSD17B2 inhibition	0	Molecular	Aug 9, 2024	Aug 12, 2024	565: 17β-Hydroxysteroid dehydrogenase 2, inhibition leading to activation, estrogen receptor alpha