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All Key Events

Showing 576 to 600 of 1939 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1858	Increased viral transcription and replication Short Name	0	Cellular	Apr 9, 2021	Apr 9, 2021	None
1857	Platelet-neutrophil interactions, Increased Short Name	0	Cellular	Apr 8, 2021	Apr 8, 2021	2 AOPs 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) 412: Endothelial cell dysfunction leading to thromboinflammation
1856	Imbalanced salty and sweet taste responses Short Name Sodium inhibition, Sweet enhancement	0	Tissue	Apr 7, 2021	Apr 7, 2021	381: Binding of viral S-glycoprotein to ACE2 receptor leading to dysgeusia
1855	Increased Sodium-sensitive hypertension Short Name Increased Sodium-sensitive hypertension	0	Tissue	Apr 7, 2021	Apr 7, 2021	384: Hyperactivation of ACE/Ang-II/AT1R axis leading to chronic kidney disease
1854	Dysregulation, ACE2 expression and activity Short Name ACE2 dysregulation	4	Molecular	Mar 31, 2021	Feb 18, 2023	3 AOPs 385: Viral spike protein interaction with ACE2 leads to microvascular dysfunction, via ACE2 dysregulation 428: Binding of S-protein to ACE2 in enterocytes induces ACE2 dysregulation leading to gut dysbiosis 319: Binding to ACE2 leading to lung fibrosis
1853	Hyperactivation of ACE/Ang-II/AT1R axis Short Name Hyperactivation of ACE/Ang-II/AT1R axis	0	Molecular	Mar 31, 2021	Mar 31, 2021	2 AOPs 384: Hyperactivation of ACE/Ang-II/AT1R axis leading to chronic kidney disease 427: ACE2 downregulation following SARS-CoV-2 infection triggers dysregulation of RAAS and can lead to heart failure.
1852	Increased Ang II type 1 receptor (AT1R) Short Name Increased Ang II type 1 receptor (AT1R)	0	Tissue	Mar 30, 2021	Mar 30, 2021	2 AOPs 383: Inhibition of Angiotensin-converting enzyme 2 leading to liver fibrosis 384: Hyperactivation of ACE/Ang-II/AT1R axis leading to chronic kidney disease
1851	Binding of agonist, Angiotensin II receptor type 1 receptor (AT1R) Short Name	0	Molecular	Mar 30, 2021	Mar 30, 2021	2 AOPs 382: Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis 319: Binding to ACE2 leading to lung fibrosis
1850	dysgeusia Short Name taste impairment	0	Organ	Mar 28, 2021	Apr 26, 2021	381: Binding of viral S-glycoprotein to ACE2 receptor leading to dysgeusia
1849	Impaired gustatory nerve Short Name Impaired gustatory nerve	0	Tissue	Mar 28, 2021	Apr 7, 2021	381: Binding of viral S-glycoprotein to ACE2 receptor leading to dysgeusia
1848	Toll Like Receptor (TLR) Dysregulation Short Name TLR Activation/Dysregulation	0	Molecular	Mar 26, 2021	Nov 23, 2021	3 AOPs 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) 378: Dysregulated underperforming Toll Like Receptors (TLRs) leading to high pathogen load 320: Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality
1847	Increased SARS-CoV-2 production Short Name SARS-CoV-2 production	5	Cellular	Mar 25, 2021	Jun 14, 2022	8 AOPs 379: Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation 320: Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality 406: SARS-CoV-2 infection leading to hyperinflammation 407: SARS-CoV-2 infection leading to pyroptosis 422: Binding of SARS-CoV-2 to ACE2 in enterocytes leads to intestinal barrier disruption 430: Binding of SARS-CoV-2 to ACE2 leads to viral infection proliferation 394: SARS-CoV-2 infection of olfactory epithelium leading to impaired olfactory function (short-term anosmia) 468: Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death)
1846	Thrombosis and Disseminated Intravascular Coagulation Short Name Thrombosis and DIC	3	Individual	Mar 25, 2021	Nov 25, 2022	3 AOPs 379: Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation 395: Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on pericytes leads to disseminated intravascular coagulation resulting in cerebrovascular disease (stroke) 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
1845	Coagulation Short Name Coagulation	1	Organ	Mar 25, 2021	Aug 30, 2023	379: Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation
1844	systemic inflammatory response syndrome Short Name SIRS	0	Individual	Mar 19, 2021	Mar 19, 2021	2 AOPs 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) 393: AOP for thyroid disorder caused by triphenyl phosphate via TRβ activation
1843	Multi Organ Failure involving Acute Respiratory Distress Syndrome Short Name ARDS and MODS	0	Individual	Mar 19, 2021	Nov 19, 2021	377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
1842	Prolonged TLR9 activation Short Name TLR9 activation	0	Molecular	Mar 19, 2021	Mar 26, 2021	377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
1841	Encephalitis Short Name Encephalitis	0	Organ	Feb 23, 2021	Feb 23, 2021	2 AOPs 374: Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on brain cells (neuronal and non-neuronal) leads to neuroinflammation resulting in encephalitis 471: Neuron defect induced early behavioral change
1840	Inhibition, cytochrome oxidase Short Name Inhibition, cytochrome oxidase	1	Molecular	Feb 19, 2021	Mar 18, 2025	3 AOPs 368: Cytochrome oxidase inhibition leading to increased nasal lesions 573: Inhibition, cytochrome oxidase leads to Increased, pulmonary edema 574: Inhibition, cytochrome oxidase leads to Loss of olfactory function
1839	Testicular Cancer Short Name Testicular Cancer	0	Organ	Feb 12, 2021	Feb 12, 2021	372: Androgen receptor antagonism leading to testicular cancer
1837	decreased oocyte maturation Short Name decreased oocyte maturation	0	Organ	Feb 9, 2021	Feb 9, 2021	2 AOPs 349: Inhibition of 11β-hydroxylase leading to decresed population trajectory 595: Emerging OPFRS reproductive outcome pathway
1836	Decreased plasma Cortisol level Short Name Decreased plasma Cortisol level	0	Tissue	Feb 9, 2021	Feb 9, 2021	349: Inhibition of 11β-hydroxylase leading to decresed population trajectory
1835	Cortisol and 11β-(OH) testosterone decreased Short Name	0	Cellular	Feb 9, 2021	Feb 9, 2021	349: Inhibition of 11β-hydroxylase leading to decresed population trajectory
1834	Decrease, Acyl-CoA dehydrogenases Short Name Decrease, ACAD	0	Molecular	Jan 15, 2021	Jan 15, 2021	318: Glucocorticoid Receptor activation leading to hepatic steatosis
1833	Impaired lung function Short Name Impaired lung function	0	Individual	Jan 8, 2021	Feb 16, 2021	None